Issue 8, 2016

Pd-catalyzed dehydrogenative annulation approach for the efficient synthesis of phenanthridinones

Abstract

A novel Pd-catalyzed intermolecular dehydrogenative annulation of aryl iodides and aryl carbamic chlorides for the efficient synthesis of phenanthridinone derivatives was developed. Simple aryl iodides and carbamic chlorides readily made from various anilines, a broad substrate scope with hetero/polycycles, as well as high-value products, make this direct dehydrogenative annulation approach very practical and attractive.

Graphical abstract: Pd-catalyzed dehydrogenative annulation approach for the efficient synthesis of phenanthridinones

Supplementary files

Article information

Article type
Edge Article
Submitted
13 mars 2016
Accepted
26 avr. 2016
First published
26 avr. 2016
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2016,7, 5384-5389

Pd-catalyzed dehydrogenative annulation approach for the efficient synthesis of phenanthridinones

X. Li, J. Pan, S. Song and N. Jiao, Chem. Sci., 2016, 7, 5384 DOI: 10.1039/C6SC01148A

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