Issue 6, 2012

ZnO nanoparticle-coated surfaces inhibit bacterial biofilm formation and increase antibiotic susceptibility

Abstract

Nanotechnology is providing new ways to manipulate the structure and chemistry of surfaces to inhibit bacterial colonization. In this study, we evaluated the ability of glass slides coated with zinc oxide (ZnO) nanoparticles to restrict the biofilm formation of common bacterial pathogens. The generation of hydroxyl radicals, originating from the coated surface, was found to play a key role in antibiofilm activity. Furthermore, we evaluated the ability of the nanoparticle coating to enhance the antibacterial activity of commonly-used antibiotics. The ZnO nanoparticles were synthesized and deposited on the surface of glass slides using a one-step ultrasound irradiation process. Several physico-chemical surface characterization methods were performed to prove the long-term stability and homogenity of the coated films. Collectively, our findings may open a new door for utilizing ZnO nanoparticle films as antibiofilm coating of surfaces, thus providing a versatile platform for a wide range of applications both in medical and industrial settings, all of which are prone to bacterial colonization.

Graphical abstract: ZnO nanoparticle-coated surfaces inhibit bacterial biofilm formation and increase antibiotic susceptibility

Supplementary files

Article information

Article type
Paper
Submitted
17 août 2011
Accepted
04 déc. 2011
First published
26 janv. 2012

RSC Adv., 2012,2, 2314-2321

ZnO nanoparticle-coated surfaces inhibit bacterial biofilm formation and increase antibiotic susceptibility

G. Applerot, J. Lellouche, N. Perkas, Y. Nitzan, A. Gedanken and E. Banin, RSC Adv., 2012, 2, 2314 DOI: 10.1039/C2RA00602B

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