Issue 5, 2022

A theranostic microneedle array patch for integrated glycemia sensing and self-regulated release of insulin

Abstract

Diabetes can cause various complications and affect the normal functioning of the human body. A theranostic and diagnostic platform for real-time glycemia sensing and simultaneous self-regulated release of insulin is desired to improve diabetic patients’ life quality. Here, we describe a theranostic microneedle array patch, which enables the achievement of visualization quantification of glycemia and simultaneously self-regulated release of insulin. The microneedle patch (MNDF) was fabricated by crosslinking of 3-aminophenylboronic acid (ABA)-modified sodium alginate and chondroitin sulfate. The hierarchical structure consisted of a tip part containing mineralized insulin particles and glucose oxidase (GOD) for insulin release, and a base surface embodying 3,3′,5,5′-tetramethylbenzidine (TMB) and (horseradish peroxidase) HRP for real-time glycemia sensing. In the presence of glucose, GOD converts glucose into H+ and H2O2, driving gradual dissolution of the calcium layer of insulin particles, resulting in long-acting release of insulin. By the bio-catalytic action of HRP, the generated H2O2 brings about a visible color change allowing the glucose level at the base surface to be read out. We believe that the theranostic microneedle array patch can act as a promising alternative for future clinical applications.

Graphical abstract: A theranostic microneedle array patch for integrated glycemia sensing and self-regulated release of insulin

Supplementary files

Article information

Article type
Paper
Submitted
30 nov. 2021
Accepted
16 janv. 2022
First published
20 janv. 2022

Biomater. Sci., 2022,10, 1209-1216

A theranostic microneedle array patch for integrated glycemia sensing and self-regulated release of insulin

X. Sun, W. Ji, B. Zhang, L. Ma, W. Fu, W. Qian, X. Zhang, J. Li, E. Sheng, Y. Tao and D. Zhu, Biomater. Sci., 2022, 10, 1209 DOI: 10.1039/D1BM01834E

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