Issue 45, 2021

Biological protein mediated ferroptotic tumor nanotherapeutics

Abstract

Ferroptosis, a cell death pathway involving iron-related generation of lipid hydroperoxides for achieving incredible tumor suppression, has reignited the hope of chemotherapy in tumor treatment in the past decade. With extensive research studies, various bioactive proteins and cellular pathways have been demonstrated to regulate the occurrence and development of ferroptosis. The gradually established ferroptotic regulatory network is conducive to find effective proteins from a holistic perspective and guides better designs for future ferroptotic tumor therapies. The first section of this review summarizes the recent advances in ferroptotic regulatory mechanisms of proteins and attempts to clarify their latent function in the ferroptotic regulatory network. Second, the existing protein-mediated ferroptotic tumor nanotherapeutic strategies were reviewed, including the protein-mediated iron supplement, cell membrane transporter inhibition, glutathione peroxidase 4 interference, glutathione depletion, bioenzyme-mediated reactive oxygen species generation, heat shock protein inhibition, and tumor-overexpressed protein-triggered drug release for ferroptotic therapy. Finally, the future expectations and challenges of ferroptotic tumor nanotherapeutics for clinical cancer therapy are highlighted.

Graphical abstract: Biological protein mediated ferroptotic tumor nanotherapeutics

Article information

Article type
Review Article
Submitted
07 juin 2021
Accepted
03 oct. 2021
First published
03 nov. 2021

J. Mater. Chem. B, 2021,9, 9262-9284

Biological protein mediated ferroptotic tumor nanotherapeutics

J. Tao, C. Li, Y. Zheng, F. Wang, M. Zhang, X. Wu, Y. Chen, Q. Zeng, F. Chen and W. Fei, J. Mater. Chem. B, 2021, 9, 9262 DOI: 10.1039/D1TB01289D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements