Issue 65, 2021

Visible-light-facilitated P-center radical addition to C[double bond, length as m-dash]X (X = C, N) bonds results in cyclizations

Abstract

Visible-light-facilitated phosphorus radical reactions have been developed as a powerful and sustainable tool for the synthesis of various organophosphorus compounds. In general, these reactions require stoichiometric amounts of oxidants, and reductants, bases, and radical initiators, leading to uneconomical and complicated processes. Progress has been made over the past few years toward using reactions that proceed under eco-benign and mild reaction conditions. Furthermore, these reactions have broad functional group tolerance, with some facile and economical pathways. Herein, we summarize the discoveries and achievements pertaining to C–P bond formation through a visible light photocatalysis procedure with high atom economy, made by our group and other research groups. It was established that greener and more environmentally friendly approaches do not require an additional oxidant or base. Moreover, we have designed and synthesized a new type of P-radical precursor, which can take part in reactions without the requirement for any additional bases, oxidants, and additives. This breakthrough, pertaining to novel visible-light-induced transformations, will be discussed and a plausible mechanism is proposed, based on corresponding experiments and the literature.

Graphical abstract: Visible-light-facilitated P-center radical addition to C [[double bond, length as m-dash]] X (X = C, N) bonds results in cyclizations

Article information

Article type
Feature Article
Submitted
18 mai 2021
Accepted
20 juil. 2021
First published
21 juil. 2021

Chem. Commun., 2021,57, 7997-8002

Visible-light-facilitated P-center radical addition to C[double bond, length as m-dash]X (X = C, N) bonds results in cyclizations

C. Li, J. Wang and S. Yang, Chem. Commun., 2021, 57, 7997 DOI: 10.1039/D1CC02604F

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