Issue 41, 2020

Total synthesis of thioamycolamide A via a biomimetic route

Abstract

Thioamycolamide A is a biosynthetically unique cytotoxic cyclic microbial lipopeptide that bears a D-configured thiazoline, a thioether bridge, a fatty acid side chain, and a reduced C-terminus. Based on the biosynthetic insights, a concise total synthesis of thioamycolamide A was accomplished.

Graphical abstract: Total synthesis of thioamycolamide A via a biomimetic route

Supplementary files

Article information

Article type
Communication
Submitted
22 sept. 2020
Accepted
05 oct. 2020
First published
08 oct. 2020

Org. Biomol. Chem., 2020,18, 8366-8370

Total synthesis of thioamycolamide A via a biomimetic route

C. Pan, T. Kuranaga and H. Kakeya, Org. Biomol. Chem., 2020, 18, 8366 DOI: 10.1039/D0OB01942A

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