Issue 11, 2020

Total synthesis of isatindigotindoline C

Abstract

Total synthesis of isatindigotindoline C, a 3,3′-spiropyrrolidine oxindole alkaloid, is achieved in two steps using an exo-selective decarboxylative 1,3-dipolar cycloaddition as the key step. The synthesis verifies the originally assigned relative anti-stereochemistry for the bis-oxindole core of isatindigotindoline C.

Graphical abstract: Total synthesis of isatindigotindoline C

Supplementary files

Article information

Article type
Communication
Submitted
06 févr. 2020
Accepted
02 mars 2020
First published
02 mars 2020

Org. Biomol. Chem., 2020,18, 2051-2053

Author version available

Total synthesis of isatindigotindoline C

J. H. Siitonen, S. Lira, M. Yousufuddin and L. Kürti, Org. Biomol. Chem., 2020, 18, 2051 DOI: 10.1039/D0OB00270D

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