Issue 16, 2020

Sub-stoichiometric reductive etherification of carbohydrate substrates and one-pot protecting group manipulation

Abstract

In this study, we report a new reductive etherification procedure for protection of carbohydrate substrates and its application for one-pot preparation of glycosyl building blocks. The reported procedure features the use of polymethylhydrosiloxane (PMHS) as a sub-stoichiometric reducing agent, which prevents the transilylation side reaction and improves the efficiency of the reductive etherification method. Application of the PMHS reductive etherification procedure for one-pot protecting group manipulation are described.

Graphical abstract: Sub-stoichiometric reductive etherification of carbohydrate substrates and one-pot protecting group manipulation

Supplementary files

Article information

Article type
Paper
Submitted
05 févr. 2020
Accepted
31 mars 2020
First published
31 mars 2020

Org. Biomol. Chem., 2020,18, 3135-3141

Sub-stoichiometric reductive etherification of carbohydrate substrates and one-pot protecting group manipulation

C. W. Chen, C. C. Wang, X. R. Li, H. Witek and K. T. Mong, Org. Biomol. Chem., 2020, 18, 3135 DOI: 10.1039/D0OB00252F

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