Issue 39, 2019

Facile access to evodiakine enabled by aerobic copper-catalyzed oxidative rearrangement

Abstract

Oxidation as a fundamentally important method for the synthesis of complex structures is difficult to achieve in a selective manner. Evodiakine, a complex natural product possessing an unprecedented ring system (6/5/5/7/6), has a high oxidation state without a practical solution. Herein, we report the first synthesis of evodiakine via aerobic copper-catalyzed late-stage functionalization of evodiamine.

Graphical abstract: Facile access to evodiakine enabled by aerobic copper-catalyzed oxidative rearrangement

Supplementary files

Article information

Article type
Communication
Submitted
20 août 2019
Accepted
24 sept. 2019
First published
25 sept. 2019

Org. Biomol. Chem., 2019,17, 8811-8815

Facile access to evodiakine enabled by aerobic copper-catalyzed oxidative rearrangement

Y. Su, G. Huang, F. Ye, P. Qiao, J. Ye, Y. Gao and H. Chen, Org. Biomol. Chem., 2019, 17, 8811 DOI: 10.1039/C9OB01832H

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