Issue 7, 2019

Mechanism of nitrones and allenoates cascade reactions for the synthesis of dihydro[1,2-a]indoles

Abstract

Quantum mechanical calculations (DLPNO-CCSD(T) and dispersion-corrected DFT) are employed to gain insights into the mechanism and selectivity in the catalytic synthesis of dihydropyrido[1,2-a]indoles from the cascade reaction between nitrones and allenes. Implications for controlling diverging pathways is discussed.

Graphical abstract: Mechanism of nitrones and allenoates cascade reactions for the synthesis of dihydro[1,2-a]indoles

Supplementary files

Article information

Article type
Communication
Submitted
21 sept. 2018
Accepted
14 nov. 2018
First published
14 nov. 2018

Org. Biomol. Chem., 2019,17, 1767-1772

Author version available

Mechanism of nitrones and allenoates cascade reactions for the synthesis of dihydro[1,2-a]indoles

W. Lee, M. Yuan, C. Acha, A. Onwu and O. Gutierrez, Org. Biomol. Chem., 2019, 17, 1767 DOI: 10.1039/C8OB02346H

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