Issue 7, 2019

Synthesis of the core structure of phalarine

Abstract

The core skeleton of phalarine was rapidly synthesised through novel palladium-catalysed dearomative spirocyclisation and a palladium-catalysed Wacker-carbonylative cyclisation cascade. The two key steps allowed for the efficient construction of a tricyclic propeller skeleton bearing contiguous tetrasubstituted carbon centres, within 3 steps from a topologically planar precursor.

Graphical abstract: Synthesis of the core structure of phalarine

Supplementary files

Article information

Article type
Communication
Submitted
19 sept. 2018
Accepted
29 sept. 2018
First published
01 oct. 2018

Org. Biomol. Chem., 2019,17, 1727-1730

Author version available

Synthesis of the core structure of phalarine

K. Douki, J. Shimokawa and M. Kitamura, Org. Biomol. Chem., 2019, 17, 1727 DOI: 10.1039/C8OB02320D

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