Issue 37, 2018

Recent advances in the synthesis of azaphenalene alkaloids: first enantioselective approaches

Abstract

Azaphenalene alkaloids are biosynthesised and segregated by diverse insects of the Coccinellidae family (ladybirds) and are believed to play an important role in the defensive mechanism against their natural predators. The particular unique framework of these alkaloids, along with their potential in the field of biological pest control, has led to several research groups developing synthetic sequences to prepare these compounds. The main purpose of the present review is to provide an update of the more recent synthetic progress towards these alkaloids, including the pioneering enantioselective approaches to chiral congeners.

Graphical abstract: Recent advances in the synthesis of azaphenalene alkaloids: first enantioselective approaches

Article information

Article type
Review Article
Submitted
19 juin 2018
Accepted
02 août 2018
First published
03 août 2018

Org. Biomol. Chem., 2018,16, 8218-8229

Recent advances in the synthesis of azaphenalene alkaloids: first enantioselective approaches

S. Alujas-Burgos, P. Bayón and M. Figueredo, Org. Biomol. Chem., 2018, 16, 8218 DOI: 10.1039/C8OB01443D

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