Issue 40, 2014

68Ga chelating bioorthogonal tetrazine polymers for the multistep labeling of cancer biomarkers

Abstract

We have developed a 68Ga metal chelating bioorthogonal tetrazine dextran probe that is highly reactive with trans-cyclooctene modified monoclonal antibodies for multistep imaging applications. Confocal microscopy and positron emission tomography (PET) were used to characterize the dextran probe in vitro and in vivo.

Graphical abstract: 68Ga chelating bioorthogonal tetrazine polymers for the multistep labeling of cancer biomarkers

Supplementary files

Article information

Article type
Communication
Submitted
16 déc. 2013
Accepted
19 févr. 2014
First published
21 févr. 2014

Chem. Commun., 2014,50, 5215-5217

Author version available

68Ga chelating bioorthogonal tetrazine polymers for the multistep labeling of cancer biomarkers

B. Nichols, Z. Qin, J. Yang, D. R. Vera and N. K. Devaraj, Chem. Commun., 2014, 50, 5215 DOI: 10.1039/C3CC49530B

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