An efficient method for the visible-light-induced radical trifluoromethylation/cyclization of N-arylacrylamides with trifluoromethyl phenyl sulfone was developed.
A visible-light-induced deoxygenative alkylation/cyclization of acrylamides with alcohols activated by CS2 has been developed by using xanthate salts as alkyl radical precursors in the presence of tricyclohexylphosphine.
Various 3,3-disubstituted oxindoles and 3,4-disubstituted dihydroquinolin-2(1H)-ones were synthesized via persulfate promoted intermolecular radical addition/cyclization of 4-carbamoyl-Hantzsch esters with N-arylacrylamides and N-arylcinnamamides.
An electrochemical monofluoroalkylation cyclization of N-arylacrylamides to synthesize monofluorinated 2-oxindoles has been developed.
Redox-neutral coupling and cyclization: A photocatalyst- and additive-free method for the preparation of valuable 3,3-disubstituted oxindoles bearing trifluoromethyl alcohol moieties with formal 100% atom economy.