Different molecular recognition by three domains of the full-length GRB2 to SOS1 proline-rich motifs and EGFR phosphorylated sites

Abstract

The asymmetric physical properties of the two SH3 domains of GRB2, including dynamics and binding affinities, may contribute to the formation of liquid–liquid phase separation.

Double-hybrid density functionals applied to a large set of INVEST systems: validating the (SOS1-)PBE-DH-INVEST expressions

Abstract

We thoroughly assess here the recently developed (SOS1-)PBE-DH-INVEST double-hybrid density functionals using the NAH159 dataset, in the search of a robuts and accurate method for S₁–T₁ gaps.

Nanomaterial-modulated cellular sodium extrusion and vacuolar sequestration for salt tolerance

Abstract

Nanomaterials can induce plant tolerance to abiotic environmental stresses, whereas the sensing mechanism and the resulting response at the cellular level need further exploration.

Monophthalates of betulinic acid and related pentacyclic triterpenes inhibit efficiently the SOS-mediated nucleotide exchange and impact PI3K/AKT signaling in oncogenic K-RAS4B proteins

Abstract

36436308255New derivatives of betulinic, ursolic, and oleanolic acid inhibit GDP/GTP exchange at low micromolar levels and act as a molecular glue that stabilizes an unproductive K-RAS4B^allo:SOS complex.

Peptide design to control protein–protein interactions

Abstract

Targeting of protein–protein interactions has become of huge interest in every aspect of medicinal and biological sciences.

CHAPTER 4
Difluoromethyl 2-Pyridyl Sulfone: A Versatile Reagent for the Synthesis of Organofluorine Compounds