This review describes the recent advancements in visible light-induced bromine radical enhanced hydrogen atom transfer (HAT) reactions in organic synthesis.
Halogen bonding-assisted Csp3–Br homolysis and bromine radical-mediated oxidative deboronation make visible-light-driven photocatalyst-free alkyl Suzuki–Miyaura coupling of alkenylboronic acids/esters with α-bromodifluoroacylarenes accessible.
This review focuses on the progress in catalytic asymmetric difluoroalkylation to construction of difluoroalkylated stereogenic centers. Synthetic methods, active intermediates involved and asymmetric strategies applied were summarized.
A visible-light-mediated selective difluoroalkylation of α-trifluoromethyl alkenes with difluoroalkylating reagents was developed. This protocol allowed the formation of gem-difluoroalkene difluoroacetates and trifluoromethylated difluoroacetamides.
Light-promoted direct aromatic C–H difluroalkylation of aniline derivatives with bromodifluoro esters and amides has been disclosed. This reaction operates under catalyst-free conditions and features a broad substrate scope.