An efficient approach for the synthesis of highly diverse tetrahydroquinazoline scaffolds from 2-aminobenzonitriles and alkylidene malonates via 1,4-conjugate addition followed by an unprecedented rearrangement reaction in excellent yields is reported.
The hydride transfer-enabled divergent application of 5-amino-isoxazoles for the controllable construction of diverse tetrahydroquinolines and tetrahydroquinazolines was disclosed with the employment of different Lewis acids.
We disclosed a TBHP mediated cyanoalkylation/cyanoalkenylation reaction of 2-anilino-1,4-naphthoquinones with vinylarenes/arylalkynes and azobis(alkylcarbonitrile)s in a one-pot three-component fashion via a radical cascade pathway.
A new domino approach enables the simultaneous construction of a benzene ring, along with amine and fluorine installation. Resulting ortho-fluoroanilines can be used to synthesize new fluorinated azo dye and antiviral (tetrahydro)quinazolines.
The discovery of novel CDK2 inhibitors is crucial for developing targeted anticancer therapies.