Madecassic acid and silybin have been conjoined to produce hybrid compounds with improved and different activity against liver cancer cells.
A highly efficient, one-step stereo- and regioselective conversion of 6-deoxy-β-D-galacto-heptopyranosides to 6-deoxy-β-D-ido-heptopyranosides is reported to obtain several oligosaccharides related to the capsular polysaccharides of C. jejuni HS:4.
The first chiral allocolchicine–aryne intermediate for the diversity-oriented synthesis of heterocyclic allocolchicinoids in non-racemic form.
We have successfully developed an efficient approach for the first synthesis of gitonin from tigogenin. In a preliminary MTT bioassay, gitonin and structural analogues showed potent antiproliferative activities against A549, HepG2, and MCF-7 cell lines.
In galactosylation by β4GalT7 of 2-naphthyl xylosyl sulfoxides, higher affinity for the enzyme was observed for the acceptor substrate having the (R)S-configuration than for the diastereomer with the (S)S-configuration.