A PyBroP/base-promoted three-component decarboxylative addition using β-keto acids, isatylidene malononitriles and pyridine N-oxides as coupling partners for the synthesis of 3,3-disubstituted oxindole-fused pyridines has been developed.
An approach to unprecedented 4-(pyridin-2-yloxy)-1,2,4-thiadiazol-5(4H)-ones was developed. The method involves amidoximes O-heteroarylation by pyridine N-oxides with PyBroP activation, followed by condensation with chlorocarbonylsulfenyl chloride.
We report a rapid and eco-friendly synthesis of heteroaryl ethers. This innovative process involves the reaction of azine N-oxides with phenol derivatives, utilizing an in situ prepared phosphonium salt as the activating agent.
An attractive topic of metal-free methods is to achieve oxindoles that bear an N-heteroaromatic group-substituted quaternary center at the 3-position.
Post-synthesis modification (PSM) is an efficient means to introduce functional chemical groups into metal–organic frameworks (MOFs) by modifying metal clusters or ligands after MOFs have been synthesized.