Kiyoshi Kakuta, Ryouta Kasahara, Kazuki Sato and Takeshi Wada
Org. Biomol. Chem., 2023,21, 7580-7592
Abstract
This report describes a method for the synthesis of oligonucleotides without nucleobase protection using oxazaphospholidine monomers which have a long alkyl chain.
Julian Marlyn, Olivia Del Carlo, James D. Thorpe and Masad J. Damha
Green Chem., 2025,27, 8313-8318
Abstract
This study finds resonant acoustic mixing to be an effective tool in solvent minimization and rate acceleration in a variety of functionalization and protection reactions on nucleosides.
Yasufumi Fuchi, Kouki Watanabe, Misa Shoji, Yuta Ito and Yoshiyuki Hari
Org. Biomol. Chem., 2023,21, 5203-5213
Abstract
Purine derivatives of Me-TaNA (methylated three-acetal-containing nucleic acid) were synthesized and incorporated into oligonucleotides. The modified oligonucleotides exhibited high duplex stability with single-stranded RNA.
Anna Kuszczynska, Milena Bors, Karolina Podskoczyj and Grazyna Leszczynska
Org. Biomol. Chem., 2024,22, 7271-7286
Abstract
This article provides a comprehensive, up-to-date review on the chemical production of RNA oligomers containing epitranscriptomic 5-modified cytidines (hm5C, f5C, and ca5C).
Komal Chillar, Yipeng Yin, Alexander Apostle and Shiyue Fang
Org. Biomol. Chem., 2023,21, 9005-9010
Abstract
Using PEGylated Dmoc (pDmoc) phosphoramidites for oligodeoxynucleotide (ODN) synthesis increases the solubility of ODN on solid support and enables the synthesis of longer sensitive ODNs.