We applied AI-aided retrosynthesis strategy optimized synthesis routes for several anti-COVID-19 drugs.
A green method for synthesizing 3-hydroxy-5-arylpyrazine-2-carboxamides, structural analogs of favipiravir, has been developed through a one-pot condensation of arylglyoxals and 2-aminopropanediamide in an alkaline solution.
Robust arene-anchored polydentate siloxide ligands allow to control unwanted ligand rearrangements for the isolation of Tb(IV) complexes thus enabling the use of the Tb(III)/Tb(IV) couple for the separation of Tb from the neighboring Dy ion.
In this review, we summarize the recent advances in newly reported macrocyclic arenes, focusing on their synthetic strategies and applications.
Formation of 3D frameworks from 2D precursors: a protecting group-dependent functionalization of 5-aminopyrazoles is disclosed via a dearomative functionalization strategy.