Current status ofN-,O-,S-heterocycles as potential alkaline phosphatase inhibitors: a medicinal chemistry overview

Rabab S. Jassas, Nafeesa Naeem, Amina Sadiq, Rabia Mehmood, Noof A. Alenazi, Munirah M. Al-Rooqi, Ehsan Ullah Mughal, Reem I. Alsantali and Saleh A. Ahmed

RSC Adv., 2023, 13, 16413
DOI: 10.1039/D3RA01888A

Novel isatin–triazole based thiosemicarbazones as potential anticancer agents: synthesis, DFT and molecular docking studies

Alia Mushtaq, Rabbia Asif, Waqar Ahmed Humayun and Muhammad Moazzam Naseer

RSC Adv., 2024, 14, 14051
DOI: 10.1039/D4RA01937G

Novel 4-thiophenyl-pyrazole, pyridine, and pyrimidine derivatives as potential antitumor candidates targeting both EGFR and VEGFR-2; design, synthesis, biological evaluations, andin silicostudies

Samia M. Al-Muntaser, Ahmed A. Al-Karmalawy, Abeer M. El-Naggar, Ali Khalil Ali, Nour E. A. Abd El-Sattar and Eslam M. Abbass

RSC Adv., 2023, 13, 12184
DOI: 10.1039/D3RA00416C

CDK2 inhibitors: rationally directed discovery of a novel potent lead derived from cyclohepta[e]thieno[2,3-b]pyridine

Omaima F. Ibrahim, Raed M. Maklad, Hajjaj H. M. Abdu-Allah, Yasmin M. Syam and Etify A. Bakhite

RSC Med. Chem., 2025
DOI: 10.1039/D5MD00346F

Recent studies on protein kinase signaling inhibitors based on thiazoles: review to date

Manal S. Ebaid, Hoda Atef Abdelsattar Ibrahim, Asmaa F. Kassem and Ahmed Sabt

RSC Adv., 2024, 14, 36989
DOI: 10.1039/D4RA05601A

Identification and molecular mechanism of novel 5-alkenyl-2-benzylaminothiazol-4(5H)-one analogs as anti-melanogenic and antioxidant agents

Min Kyung Kang, Dahye Yoon, Hee Jin Jung, Sultan Ullah, Jieun Lee, Hye Soo Park, Hye Jin Kim, Dongwan Kang, Yujin Park, Pusoon Chun, Hae Young Chung and Hyung Ryong Moon

Bioorganic Chemistry, 2023, 140, 106763
DOI: 10.1016/j.bioorg.2023.106763

Design and synthesis of novel substituted s‐triazines tethered benzenesulfonamides as potential antimicrobial candidates: Antibiofilm and bacterial protein permeability assessments

Ahmed A. Al‐Karmalawy, Haytham O. Tawfik, Gharieb S. El‐Sayyad, Ayman Abo Elmaaty, Sobhy S. Abdel‐Fatah, Akhtar Atiya, Abdullah Yahya Abdullah Alzahrani, Arwa Omar Al Khatib, Mervat H. El‐Hamamsy and Heba A. Elsebaie

Archiv der Pharmazie, 2025, 358
DOI: 10.1002/ardp.202400931

Design and synthesis of benzo[b]thiophene‐based hybrids as novel antitubercular agents against MDR/XDR Mycobacterium tuberculosis

Tarfah Al‐Warhi, Nermeen M. Rashad, Hadia Almahli, Marwa M. Abdel‐Aziz, Zainab M. Elsayed, Mai I. Shahin and Wagdy M. Eldehna

Archiv der Pharmazie, 2024, 357
DOI: 10.1002/ardp.202300529

Insight into the therapeutic potential of pyrazole‐thiazole hybrids: A comprehensive review

Garima Sumran, Manisha Sharma and Ranjana Aggarwal

Archiv der Pharmazie, 2024, 357
DOI: 10.1002/ardp.202400576

Evaluation of 2,3-Dihydro-1,5-benzothiazepine Derivatives as Potential Tyrosinase Inhibitors: In Vitro and In Silico Studies

Munirah M. Al-Rooqi, Amina Sadiq, Rami J. Obaid, Zaman Ashraf, Yasir Nazir, Rabab S. Jassas, Nafeesa Naeem, Meshari A. Alsharif, Syed Wadud Ali Shah, Ziad Moussa, Ehsan Ullah Mughal, Abdel-Rahman Farghaly and Saleh A. Ahmed

ACS Omega, 2023, 8, 17195
DOI: 10.1021/acsomega.3c01566

Identification of sulphonamide-tethered N -((triazol-4-yl)methyl)isatin derivatives as inhibitors of SARS-CoV-2 main protease

Mai H. ElNaggar, Abdullah A. Elgazar, Ghada Gamal, Shimaa M. Hamed, Zainab M. Elsayed, Mohamed K. El-Ashrey, Amira Abood, Mahmoud A. El Hassab, Ahmed M. Soliman, Ramadan A. El-Domany, Farid A. Badria, Claudiu T. Supuran and Wagdy M. Eldehna

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023, 38
DOI: 10.1080/14756366.2023.2234665

Thieno[2,3‐c]isoquinolines: A novel chemotype of antiproliferative agents inducing cellular apoptosis while targeting the G2/M phase and Tubulin

Islam S. Marae, Raed M. Maklad, Safia Samir, Etify A. Bakhite and Walid Sharmoukh

Drug Development Research, 2023, 84, 747
DOI: 10.1002/ddr.22054

Complexation-based spectrofluorimetric method for besifloxacin determination: Combined experimental and computational insights

Abobakr A. Mohamed, Raed M. Maklad, Abdallah M. Zeid and Islam M. Mostafa

Analytica Chimica Acta, 2025, 1372, 344446
DOI: 10.1016/j.aca.2025.344446

Design, synthesis, molecular docking, ADMET studies, and biological activity evaluation of new 2-({[3-aryl-1,2,4-oxadiazol-5-yl)methyl]thio}-1H-benzimidazoles and 6-amino-6-aryl-5,6-dihydro[1,6,2,4]oxathiadiazocino[4,5-a]benzimidazol-3(2H)-ones

Mohamed Sharaf, Amr H. Moustafa, Rami J. Obaid, Abdullah Y.A. Alzahrani, Moustafa O. Aboelez, Hazem Elkady, Noof A. Alenazi, Mounir A.A. Mohamed, Jabir H. Al-Fahemi, Ziad Moussa, Omran A. Omran and Saleh A. Ahmed

Journal of Molecular Structure, 2024, 1295, 136708
DOI: 10.1016/j.molstruc.2023.136708

Identification of new anti-mycobacterial agents based on quinoline-isatin hybrids targeting enoyl acyl carrier protein reductase (InhA)

Eman F. Khaleel, Ahmed Sabt, Malgorzata Korycka-Machala, Rehab Mustafa Badi, Ninh The Son, Nguyen Xuan Ha, Mohamed Farouk Hamissa, Ahmed E. Elsawi, Eslam B. Elkaeed, Bozena Dziadek, Wagdy M. Eldehna and Jaroslaw Dziadek

Bioorganic Chemistry, 2024, 144, 107138
DOI: 10.1016/j.bioorg.2024.107138

Chemistry and uses of 1-(2-benzothiazolyl)pyrazolines: a mini-review

Gheorghe Roman

Monatsh Chem, 2024, 155, 401
DOI: 10.1007/s00706-024-03182-8

Organocatalytic synthesis of novel pyrazoline and pyrimidine derivatives as potent thymidine kinase inhibitors targeting Staphylococcus aureus

Mohammed Issa Alahmdi, Avijit Bhakta, Meshari A. Alsharif, Sayeed Mukhtar, Humaira Parveen, Apurva Singh, Nader E. Abo-Dya, Yahya Hamed Yahya Almalky, Mohmmad Younus Wani and Naseem Ahmed

Journal of Molecular Structure, 2025, 1328, 141427
DOI: 10.1016/j.molstruc.2025.141427

Emerging insights into pyrazoline motifs: A comprehensive exploration of biological mechanisms and prospects for future advancements

Hesham A. Abou-Zied, Eman A.M. Beshr, Alaa M. Hayallah and Mohamed Abdel-Aziz

Journal of Molecular Structure, 2024, 1296, 136807
DOI: 10.1016/j.molstruc.2023.136807

Discovery of pyrimidine-tethered benzothiazole derivatives as novel anti-tubercular agents towards multi- and extensively drug resistant Mycobacterium tuberculosis

Loah R. Hemeda, Mahmoud A. El Hassab, Mohamed A. Abdelgawad, Eman F. Khaleel, Marwa M. Abdel-Aziz, Faizah A. Binjubair, Sara T. Al-Rashood, Wagdy M. Eldehna and Mohamed K. El-Ashrey

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023, 38
DOI: 10.1080/14756366.2023.2250575

Design, synthesis, and in silico insights of novel N’-(2-oxoindolin-3-ylidene)piperidine-4-carbohydrazide derivatives as VEGFR-2 inhibitors

Wagdy M. Eldehna, Youmna A. Habib, Abeer E. Mahmoud, Mohamed F. Barghash, Zainab M. Elsayed, Ahmed E. Elsawi, Raed M. Maklad, Mahmoud Rashed, Amira Khalil, Sherif F. Hammad, Mamdouh M. Ali and Ahmed M. El Kerdawy

Bioorganic Chemistry, 2024, 153, 107829
DOI: 10.1016/j.bioorg.2024.107829

Substituted Benzalacetophenone Molecules: A Computational Investigation of Structural, PED & Non‐Linear Optical Properties

Ehsan Ullah Mughal, Nafeesa Naeem, Samia Kausar, Munirah M. Al‐Rooqi, Rabab S. Jassas, Amina Sadiq, Ataf Ali Altaf, Rami J. Obaid and Saleh A. Ahmed

ChemistrySelect, 2023, 8
DOI: 10.1002/slct.202301026

Novel indolinone-tethered benzothiophenes as anti-tubercular agents against MDR/XDR M. tuberculosis: Design, synthesis, biological evaluation and in vivo pharmacokinetic study

Wagdy M. Eldehna, Sally Tarek Mahmoud, Esraa R. Elshnawey, Zainab M. Elsayed, Taghreed A. Majrashi, Mohamed K. El-Ashrey, Mahmoud Rashed, Loah R. Hemeda, Aly A. Shoun, Eslam B. Elkaeed, Mahmoud A. El Hassab, Marwa M. Abdel-Aziz and Mai I. Shahin

Bioorganic Chemistry, 2024, 143, 107009
DOI: 10.1016/j.bioorg.2023.107009

The Next Frontier: Unveiling Novel Approaches for Combating Multidrug-Resistant Bacteria

Praveen Mallari, Leila D. Rostami, Ida Alanko, Fadak Howaili, Meixin Ran, Kuldeep K. Bansal, Jessica M. Rosenholm and Outi M. H. Salo-Ahen

Pharm Res, 2025, 42, 859
DOI: 10.1007/s11095-025-03871-x

A new class of anticancer activity with computational studies for a novel bioactive aminophosphonates based on pyrazole moiety

Mohamed H. Baren, Seham A. Ibrahim, Munirah M. Al-Rooqi, Saleh A. Ahmed, Mohammed M. El-Gamil and Hend A. Hekal

Sci Rep, 2023, 13
DOI: 10.1038/s41598-023-40265-8

Controlling (E/Z)‐Stereoselectivity of −NHC=O Chlorination: Mechanism Principles for Wide Scope Applications

Raed M. Maklad, Gamal A. I. Moustafa, Hiroshi Aoyama and Abdullah A. Elgazar

Chemistry A European J, 2024, 30
DOI: 10.1002/chem.202400785

Design, Synthesis, and Antiproliferative and Apoptotic Assessment of Triazole‐Tethered Bisnaphthalimide‐Isatin Hybrids on Triple‐Negative Breast and Prostate Cancers

Preeti, Asif Raza, Garima Arora, Amit Anand, Arun K. Sharma and Vipan Kumar

ChemMedChem, 2025
DOI: 10.1002/cmdc.202500415

New Insights into the Structural Requirements of Isatin-Derived Pro-Apoptotic Agents against Acute Myeloid Leukemia

Ahmed K. Hamdy, Takashi Sakamoto, Tsugumasa Toma, Masaharu Sakamoto, Mohammed A. S. Abourehab, Masami Otsuka, Mikako Fujita, Hiroshi Tateishi and Mohamed O. Radwan

Pharmaceuticals, 2022, 15, 1579
DOI: 10.3390/ph15121579

Development in the Synthesis of Bioactive Thiazole-Based Heterocyclic Hybrids Utilizing Phenacyl Bromide

Ginna Kumari, Sudeep Dhillon, Priyanka Rani, Mamta Chahal, Deepak Kumar Aneja and Mayank Kinger

ACS Omega, 2024, 9, 18709
DOI: 10.1021/acsomega.3c10299