Strategic convergent synthesis en route to Veratrum steroidal alkaloids

Zhuo Wang

Org. Chem. Front., 2024, 11, 4014
DOI: 10.1039/D4QO00717D

Synthesis and biological activity evaluation of novel peroxo-bridged derivatives as potential anti-hepatitis B virus agents

Menglu Jia, Rui Zhao, Bing Xu, Wenqiang Yan, Fuhao Chu, Hongshun Gu, Tianxin Xie, Hongjun Xiang, Jian Ren, Dagang Chen, Penglong Wang and Haimin Lei

Med. Chem. Commun., 2017, 8, 148
DOI: 10.1039/C6MD00344C

Application of Nazarov type electrocyclization to access [6,5,6] and [6,5,5] core embedded new polycycles: an easy entry to tetrahydrofluorene scaffolds related to Taiwaniaquinoids and C-nor-D homosteroids

Ritesh Singh and Gautam Panda

Org. Biomol. Chem., 2011, 9, 4782
DOI: 10.1039/c0ob00892c

Editorial: Natural products chemistry in China

Nat. Prod. Rep., 2006, 23, 667
DOI: 10.1039/b611850j

Chemo- and bioinformatics resources for in silico drug discovery from medicinal plants beyond their traditional use: a critical review

Alexey A. Lagunin, Rajesh K. Goel, Dinesh Y. Gawande, Priynka Pahwa, Tatyana A. Gloriozova, Alexander V. Dmitriev, Sergey M. Ivanov, Anastassia V. Rudik, Varvara I. Konova, Pavel V. Pogodin, Dmitry S. Druzhilovsky and Vladimir V. Poroikov

Nat. Prod. Rep., 2014, 31, 1585
DOI: 10.1039/C4NP00068D

Chemistry and biological activity of steroidal glycosides from the Lilium genus

John P. Munafo Jr and Thomas J. Gianfagna

Nat. Prod. Rep., 2015, 32, 454
DOI: 10.1039/C4NP00063C

Steroidal alkaloid with unprecedented triheterocyclic architecture

Zhong-Shun Zhou, Yun-Li Zhao, Bin-Yuan Hu, Bei Wang, Ya-Ping Liu, Yan-Yan Zhu, Ying-Jie He, Zhao-Jie Wang, Zhi Dai, Li-Xing Zhao and Xiao-Dong Luo

Chem. Commun., 2023, 59, 326
DOI: 10.1039/D2CC06073F

Recent advances in the efficient synthesis of steroid natural products: emerging methods and strategies

Yu Wang and Jinghan Gui

Chem. Soc. Rev., 2025, 54, 6807
DOI: 10.1039/D3CS01150J

An enhanced strategy integrating offline superimposed two-dimensional separation with mass defect filter and diagnostic ion filter: Comprehensive characterization of steroid alkaloids in Fritillariae Pallidiflorae Bulbus as a case study

Ya-ling An, Wen-long Wei, Hao-jv Li, Zhen-wei Li, Chang-liang Yao, Hua Qu, Shuai Yao, Yong Huang, Jian-qing Zhang, Qi-rui Bi, Jia-yuan Li and De-an Guo

Journal of Chromatography A, 2021, 1643, 462029
DOI: 10.1016/j.chroma.2021.462029

Convergent and Efficient Total Synthesis of (+)-Heilonine Enabled by C–H Functionalizations

Yuan Jin, Sovanneary Hok, John Bacsa and Mingji Dai

J. Am. Chem. Soc., 2024, 146, 1825
DOI: 10.1021/jacs.3c13492

Analysis of impact and absorbed energy of Fritillaria ussuriensis maxim during drum screening and its effect on impact damage

Jiang Song, Shuai Tian, Yaoshen Wang, Xia Han, Ming Wang, Xingrong Sun and Shujuan Yi

Computers and Electronics in Agriculture, 2023, 215, 108368
DOI: 10.1016/j.compag.2023.108368

Therapeutic value of steroidal alkaloids in cancer: Current trends and future perspectives

Prasanta Dey, Amit Kundu, Hirak Jyoti Chakraborty, Babli Kar, Wahn Soo Choi, Byung Mu Lee, Tejendra Bhakta, Atanas G. Atanasov and Hyung Sik Kim

Intl Journal of Cancer, 2019, 145, 1731
DOI: 10.1002/ijc.31965

Anandins A and B, Two Rare Steroidal Alkaloids from a Marine Streptomyces anandii H41-59

Yang-Mei Zhang, Bai-Lian Liu, Xin-Heng Zheng, Xiao-Jun Huang, Hong-Yu Li, Ying Zhang, Ting-Ting Zhang, Da-Yuan Sun, Bi-Run Lin and Guang-Xiong Zhou

Marine Drugs, 2017, 15, 355
DOI: 10.3390/md15110355

Hybridization and karyotype variability of three endemic Fritillaria L. (Liliaceae) in Argolis Peninsula (Greece)

Sofia Samaropoulou, Pepy Bareka and Georgia Kamari

Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology, 2020, 154, 348
DOI: 10.1080/11263504.2019.1612478

Representational Difference Analysis of Transcripts Involved in Jervine Biosynthesis

Magdalena Szeliga, Joanna Ciura and Mirosław Tyrka

Life, 2020, 10, 88
DOI: 10.3390/life10060088

LED Lights Affecting Morphogenesis and Isosteroidal Alkaloid Contents in Fritillaria cirrhosa D. Don—An Important Chinese Medicinal Herb

Chia-Chen Chen, Maw-Rong Lee, Chi-Rei Wu, Hsin-Ju Ke, Hui-Min Xie, Hsin-Sheng Tsay, Dinesh Chandra Agrawal and Hung-Chi Chang

Plants, 2020, 9, 1351
DOI: 10.3390/plants9101351

Diastereomers of Steroidal Alkaloids with Cytotoxic Activities against Non-Small-Cell Lung Cancer from the Bulbs of Fritillaria sinica

Jia-yuan Li, Shi-fei Wu, Ya-ling An, Chang-liang Yao, Shuai Yao, Wen-long Wei, Jian-qing Zhang, Qi-rui Bi and Dean Guo

J. Nat. Prod., 2024, 87, 252
DOI: 10.1021/acs.jnatprod.3c00910

Steroidal Alkaloids with a Potent Analgesic Effect Based on N-type Calcium Channel Inhibition

Tian-Zhen Xie, Lei Luo, Yun-Li Zhao, Hao Li, Mei-Ling Xiang, Xu-Jie Qin, Ying-Jie He, Yan-Yan Zhu, Zhi Dai, Zhao-Jie Wang, Xin Wei, Ya-Ping Liu, Li-Xing Zhao, Ren Lai and Xiao-Dong Luo

Org. Lett., 2022, 24, 467
DOI: 10.1021/acs.orglett.1c02853

Unusual ring B-seco isosteroidal alkaloid, yibeiglycoalkaloids A−E from Fritillaria pallidiflora schrenk

Qiang Dong, Jun Li, Liu Liu, Haji Akber Aisa and Abulimiti Yili

Phytochemistry, 2022, 203, 113351
DOI: 10.1016/j.phytochem.2022.113351

Pharmacokinetics, tissue distribution and excretion of peimisine in rats assessed by liquid chromatography-tandem mass spectrometry

Lihua Chen, Dongxun Li, Guosong Zhang, Wei Zhang, Lihua Zhang, Yongmei Guan, Weifeng Zhu and Hongning Liu

Arch. Pharm. Res., 2015, 38, 1138
DOI: 10.1007/s12272-014-0434-1

Enantioselective Total Synthesis of (−)-Zygadenine

Yinliang Guo, Jia-Tian Lu, Runting Fang, Yang Jiao, Jiaqi Liu and Tuoping Luo

J. Am. Chem. Soc., 2023, 145, 20202
DOI: 10.1021/jacs.3c08039

Antifungal activity of potato glycoalkaloids and its potential to control severity of dry rot caused by Fusarium sulphureum

Hong Li, Ming Li, Yanling Fan, Yuhui Liu and Shuhao Qin

Crop Science, 2023, 63, 801
DOI: 10.1002/csc2.20874

Seven new veratramine-type alkaloids with potent analgesic effect from Veratrum taliense

Qiong Li, Yun-Li Zhao, Cheng-Bo Long, Pei-Feng Zhu, Ya-Ping Liu and Xiao-Dong Luo

Journal of Ethnopharmacology, 2019, 244, 112137
DOI: 10.1016/j.jep.2019.112137

Undescribed steroidal alkaloids from the bulbs of Fritillaria sinica

Jia-yuan Li, Shi-fei Wu, Ya-ling An, Chang-liang Yao, Shuai Yao, Yong Huang, Wen-long Wei, Jian-qing Zhang, Qi-rui Bi, Hua Qu and De-an Guo

Phytochemistry, 2023, 213, 113768
DOI: 10.1016/j.phytochem.2023.113768

Chemistry, Bioactivity and Geographical Diversity of Steroidal Alkaloids from the Liliaceae Family

Hui‐Jun Li, Yan Jiang and Ping Li

ChemInform, 2007, 38
DOI: 10.1002/chin.200705222

Full-Length Transcriptome Sequencing Provides Insights into Flavonoid Biosynthesis in Fritillaria hupehensis

Kunyuan Guo, Jie Chen, Yan Niu and Xianming Lin

Life, 2021, 11, 287
DOI: 10.3390/life11040287

Steroidal alkaloids from the bulbs of Fritillaria pallidiflora Schrenk and their anti-inflammatory activity

Lun Wang, Yan Jiang, Aftab Yaseen, Fu Li, Bin Chen, Xiao-Fei Shen, Chuan Zheng, Guo-Lin Zhang and Ming-Kui Wang

Bioorganic Chemistry, 2021, 112, 104845
DOI: 10.1016/j.bioorg.2021.104845

Research progress on biological regulation and biosynthesis of isosteroid alkaloids in Fritillaria

Pengyan Qi, Yuna Zhang, Chunsheng Zhao, Linlin Sun, Ronglu Bai, Lizhi Wang and Chao Sun

Plant Growth Regul, 2023, 101, 599
DOI: 10.1007/s10725-023-01046-5

QUALITY CONTROL OF FRITILLARIA UNIBRACTEATA BY UPLC-PAD FINGERPRINT COMBINED WITH HIERARCHICAL CLUSTERING ANALYSIS

Li-Zhi Wang, Bao-Zhong Duan, Zhen Wang, Lin-Fang Huang and Shi-Lin Chen

Journal of Liquid Chromatography & Related Technologies, 2012, 35, 2381
DOI: 10.1080/10826076.2011.631265

Genetic diversity of three European Veratrum species revealed by Amplified Fragment Length Polymorphism

Magdalena Szeliga, Joanna Ciura and Mirosław Tyrka

Biodiversity Research and Conservation, 2017, 47, 1
DOI: 10.1515/biorc-2017-0011

Steroidal alkaloids from the bulbs of Fritillaria unibracteata var. wabuensis and their anti-inflammatory activities

Shu-Hui Wang, Yu-Qi Wang, Qi-Qi Wang, Le Wang, Qing-Ying Zhang and Peng-Fei Tu

Phytochemistry, 2023, 209, 113640
DOI: 10.1016/j.phytochem.2023.113640

Pharmacodynamics and Cellular Uptake of Peimine and Peiminine in Inflammatory Model Non-Small-Cell Lung Cancer Epithelial Cells (A549)

Zhan-Ke Chen, Di Zhao, Su-Xiang Feng, Jiangyan Xu and Samuel Martins Silvestre

Evidence-Based Complementary and Alternative Medicine, 2022, 2022, 1
DOI: 10.1155/2022/2946201

Antifungal Activity and Fungal Metabolism of Steroidal Glycosides of Easter Lily (Lilium longiflorum Thunb.) by the Plant Pathogenic Fungus, Botrytis cinerea

John P. Munafo and Thomas J. Gianfagna

J. Agric. Food Chem., 2011, 59, 5945
DOI: 10.1021/jf200093q

Bulbus Fritillariae Cirrhosae as a Respiratory Medicine: Is There a Potential Drug in the Treatment of COVID-19?

Yunyun Quan, Li Li, Zhujun Yin, Shilong Chen, Jing Yi, Jirui Lang, Lu Zhang, Qianhua Yue and Junning Zhao

Front. Pharmacol., 2022, 12
DOI: 10.3389/fphar.2021.784335

Asymmetric Photoinduced Excited-State Nazarov Reaction

Xuelong Qiao, Shaojun Zhai, Jiwei Xu, Haibing He, Xiao He, Lianrui Hu and Shuanhu Gao

J. Am. Chem. Soc., 2024, 146, 29150
DOI: 10.1021/jacs.4c11481

Isolation and Structural Determination of Steroidal Glycosides from the Bulbs of Easter Lily (Lilium longiflorum Thunb.)

John P. Munafo, Ahalya Ramanathan, Leslie S. Jimenez and Thomas J. Gianfagna

J. Agric. Food Chem., 2010, 58, 8806
DOI: 10.1021/jf101410d

Protective effects of Cambodian medicinal plants on tert-butyl hydroperoxide-induced hepatotoxicity via Nrf2-mediated heme oxygenase-1

Dong-Sung Lee, Samell Keo, Sun-Kaing Cheng, Hyuncheol Oh and Youn-Chul Kim

Molecular Medicine Reports, 2017, 15, 451
DOI: 10.3892/mmr.2016.6011

Determination of Veratrum alkaloid contents in three Veratrum species by HPLC‐MS/MS

Julia Siegle and Jörg Pietsch

Phytochemical Analysis, 2024, 35, 1577
DOI: 10.1002/pca.3401

Natural drug sources for respiratory diseases from Fritillaria: chemical and biological analyses

Ye Wang, Hongping Hou, Qiang Ren, Haoyu Hu, Tiechui Yang and Xiwen Li

Chin Med, 2021, 16
DOI: 10.1186/s13020-021-00450-1

Extraction of total alkaloids, peimine and peiminine from the flower of Fritillaria thunbergii Miq using supercritical carbon dioxide

Xiao Ruan, Wen-xia Cui, Li Yang, Zhao-hui Li, Ben Liu and Qiang Wang

Journal of CO2 Utilization, 2017, 18, 283
DOI: 10.1016/j.jcou.2017.01.024

Chemical-toxicological diagnosis of hellebore (veratrum) poisoning

E.V. Melnik, M.V. Belova, I.A. Tyurin and G.V. Ramenskaya

Sud.-med. ekspert., 2020, 63, 34
DOI: 10.17116/sudmed20206304134

Integrating metabolomics, network pharmacology and pharmacological verification analysis provides new insights into the anti-inflammatory and anti-tussive properties of Fritillaria cirrhosa bulbs

Can Zhao, Jianyun Zhang, Zhihuang Zhao, Xueyan Li, Xin Chen, Hai Wang, Yuntong Ma, Guiqi Han and Zhuyun Yan

Journal of Ethnopharmacology, 2025, 343, 119460
DOI: 10.1016/j.jep.2025.119460

Steroidal Alkaloids fromVeratrum nigrumEnhance Glucose Uptake in Skeletal Muscle Cells

ChuHyun Kang, Joo-Hui Han, Joonseok Oh, Roshan Kulkarni, Wei Zhou, Daneel Ferreira, Tae Su Jang, Chang-Seon Myung and MinKyun Na

J. Nat. Prod., 2015, 78, 803
DOI: 10.1021/np501049g

Puqienine E: An angiotensin converting enzyme inhibitory steroidal alkaloid from Fritillaria puqiensis

Jing-Jing An, Jian-Liang Zhou, Hui-Jun Li, Yan Jiang and Ping Li

Fitoterapia, 2010, 81, 149
DOI: 10.1016/j.fitote.2009.08.012

Enhancement of Cyclopamine via Conjugation with Nonmetabolic Sugars

Randal D. Goff and Jon S. Thorson

Org. Lett., 2012, 14, 2454
DOI: 10.1021/ol300703z

Synthesis of A B C-ring subunit of C-nor-D-homo-steroidal alkaloids: towards the total synthesis of cyclopamine

Xue-Li ZHANG, Yu-Qi LIAO, Peng-Jun CAI, He-Quan YAO, Ling-Yi KONG and Hong-Bin SUN

Chinese Journal of Natural Medicines, 2013, 11, 277
DOI: 10.1016/S1875-5364(13)60029-1

A review of complementary therapies with medicinal plants for chemotherapy-induced peripheral neuropathy

Bei-Yu Wu, Chun-Ting Liu, Yu-Li Su, Shih-Yu Chen, Yung-Hsiang Chen and Ming-Yen Tsai

Complementary Therapies in Medicine, 2019, 42, 226
DOI: 10.1016/j.ctim.2018.11.022

Synthesis of All Diastereomers of the Piperidine−Alkaloid Substructure of Cyclopamine

Philipp Heretsch, Sebastian Rabe and Athanassios Giannis

Org. Lett., 2009, 11, 5410
DOI: 10.1021/ol902270f

Phytochemical Variation in Fritillaria cirrhosa D. Don (Chuan Bei Mu) in Relation to Plant Reproductive Stage and Timing of Harvest1

Katie Konchar, Xiao-Li Li, Yong-Ping Yang and Eve Emshwiller

Econ Bot, 2011, 65, 283
DOI: 10.1007/s12231-011-9170-3

TIPdb: A Database of Anticancer, Antiplatelet, and Antituberculosis Phytochemicals from Indigenous Plants in Taiwan

Ying-Chi Lin, Chia-Chi Wang, Ih-Sheng Chen, Jhao-Liang Jheng, Jih-Heng Li, Chun-Wei Tung, H.-W. Chang, L.-Y. Chuang, S. Guleria and S. Yasmin

The Scientific World Journal, 2013, 2013
DOI: 10.1155/2013/736386

Rapid discovery of cyclopamine analogs from Fritillaria and Veratrum plants using LC-Q-TOF-MS and LC-QqQ-MS

Yuan Du, Zu-Guo Zheng, Yue Yu, Zi-Tian Wu, Dan Liang, Ping Li, Yan Jiang and Hui-Jun Li

Journal of Pharmaceutical and Biomedical Analysis, 2017, 142, 201
DOI: 10.1016/j.jpba.2017.04.049

Investigation of association of chemical profiles with the tracheobronchial relaxant activity of Chinese medicinal herb Beimu derived from various Fritillaria species

Xu Wu, Shun-wan Chan, Jiang Ma, Ping Li, Pang-chui Shaw and Ge Lin

Journal of Ethnopharmacology, 2018, 210, 39
DOI: 10.1016/j.jep.2017.08.027

The complete chloroplast genome sequence of Veratrum nigrum L.

Wen-Xiao Men, Yue-Yue Song, Che Bian, He-Fei Xue, Yan-Ping Xing, Liang Xu, Ming Xie and Ting-Guo Kang

Mitochondrial DNA Part B, 2022, 7, 476
DOI: 10.1080/23802359.2022.2050475

Efficacy and safety of Chinese herbal medicine children's Zibei Xuanfei syrup in treating acute trachea-bronchitis with wind-heat invading lung syndrome: A randomized, double-blind, multicentre, controlled trial

Hua-Fang Chen, Gui-Hua Song, Gang Zhao, Wen-Sheng Zhai, Meng-Meng Sun, Zhi-Jun Huang, Bao-Qing Zhang, Hui Li and Jian-Qiao Tang

Journal of Ethnopharmacology, 2023, 309, 116207
DOI: 10.1016/j.jep.2023.116207

Therapeutic Potential of Steroidal Alkaloids in Cancer and Other Diseases

Qi‐Wei Jiang, Mei‐Wan Chen, Ke‐Jun Cheng, Pei‐Zhong Yu, Xing Wei and Zhi Shi

Medicinal Research Reviews, 2016, 36, 119
DOI: 10.1002/med.21346

Biorational insecticides in pest management

Gloria Rosell, Carmen Quero, Josep Coll and Angel Guerrero

J. Pestic. Sci., 2008, 33, 103
DOI: 10.1584/jpestics.R08-01

Determination of peimine and peiminine in Bulbus Fritillariae Thunbergii by capillary electrophoresis by indirect UV detection using N‐(1‐naphthyl)ethylenediamine dihydrochloride as probe

Lihong Liu, Wenwei You, Liujuan Zheng, Feiyu Chen and Zhimin Jia

Electrophoresis, 2012, 33, 2152
DOI: 10.1002/elps.201200021

Quantitative Content Parameter in the Standardization of Veratrum Aqua, Veratrum Lobelianum Bernh. Based Drug

E. V. Melnik, M. V. Belova, I. A. Tyurin and G. V. Ramenskaya

Razrabotka i registraciâ lekarstvennyh sredstv, 2021, 10, 107
DOI: 10.33380/2305-2066-2021-10-1-107-113

Pharmacokinetics and enterohepatic circulation of jervine, an antitumor steroidal alkaloid from Veratrum nigrum in rats

Bingjing Zheng, Caihong Wang, Wenwen Song, Xiaoxia Ye and Zheng Xiang

Journal of Pharmaceutical Analysis, 2019, 9, 367
DOI: 10.1016/j.jpha.2019.04.004

Synthesis and Evaluation of Some 17-Acetamidoandrostane and N,N-Dimethyl-7-deoxycholic Amide Derivatives as Cytotoxic Agents: Structure/Activity Studies

Yanmin Huang, Jianguo Cui, Linyi Jia, Chunfang Gan, Huacan Song, Chun Zeng and Aimin Zhou

Molecules, 2013, 18, 7436
DOI: 10.3390/molecules18077436

In vitro propagation of bulblets and LC–MS/MS analysis of isosteroidal alkaloids in tissue culture derived materials of Chinese medicinal herb Fritillaria cirrhosa D. Don

Hung-Chi Chang, Hui-Min Xie, Maw-Rong Lee, Chiu-Ying Lin, Mei-Kuen Yip, Dinesh Chandra Agrawal and Hsin-Sheng Tsay

Bot Stud, 2020, 61
DOI: 10.1186/s40529-020-00286-2

Development and validation of a liquid chromatography/electrospray ionization time-of-flight mass spectrometry method for relative and absolute quantification of steroidal alkaloids in Fritillaria species

Jian-Liang Zhou, Ping Li, Hui-Jun Li, Yan Jiang, Mei-Ting Ren and Ying Liu

Journal of Chromatography A, 2008, 1177, 126
DOI: 10.1016/j.chroma.2007.11.030

A Biomimetic Approach to C-nor-D-homo-Steroids

Philipp Heretsch, Sebastian Rabe and Athanassios Giannis

J. Am. Chem. Soc., 2010, 132, 9968
DOI: 10.1021/ja103152k

Gender-Dependent Pharmacokinetics of Veratramine in Rats: In Vivo and In Vitro Evidence

Chunming Lyu, Yufeng Zhang, Wenbin Zhou, Shen Zhang, Fang Kou, Hai Wei, Ning Zhang and Zhong Zuo

AAPS J, 2016, 18, 432
DOI: 10.1208/s12248-016-9870-9

Tetraose steroidal glycoalkaloids from potato provide resistance against Alternaria solani and Colorado potato beetle

Pieter J Wolters, Doret Wouters, Yury M Tikunov, Shimlal Ayilalath, Linda P Kodde, Miriam F Strijker, Lotte Caarls, Richard GF Visser and Vivianne GAA Vleeshouwers

eLife, 2023, 12
DOI: 10.7554/eLife.87135.3

Fritaipaines A − J, isosteroidal alkaloids with anti-neuroinflammatory activity from the bulbs of Fritillaria taipaiensis

En-Ke Qu, Mei-Li Yang, Shi-Jun Liu, Hang-Ying Li, Zai-Long Huang, Lan-Run Yang, Rui Luo, Yan-Ni Liang and Dong-Bo Zhang

Fitoterapia, 2025, 183, 106546
DOI: 10.1016/j.fitote.2025.106546

Simultaneous determination of nine nucleosides and nucleobases in differentFritillariaspecies by HPLC‐diode array detector

Xin‐Wei Cao, Jun Li, Si‐Bao Chen, Xiao‐Bo Li, Pei‐Gen Xiao, Shi‐Lin Chen and Da‐Jian Yang

J of Separation Science, 2010, 33, 1587
DOI: 10.1002/jssc.200900866

Cevanine-type alkaloids from the bulbs of Fritillaria unibracteata var. wabuensis and their antifibrotic activities in vitro

Lu Fu, Wenyue Tian, Meng-Yu Bao, Zhiyan Liu, Wen-Jing Ren, Jiazheng Liu, Wei Zhang, Zhifeng Zhang, Jin Gao, Li-Ping Bai, Zhi-Hong Jiang and Guo-Yuan Zhu

Phytochemistry, 2024, 220, 114018
DOI: 10.1016/j.phytochem.2024.114018

Terpenoid‐Alkaloids: Their Biosynthetic Twist of Fate and Total Synthesis

Emily C. Cherney and Phil S. Baran

Israel Journal of Chemistry, 2011, 51, 391
DOI: 10.1002/ijch.201100005

A Systematic Review on Traditional Uses, Sources, Phytochemistry, Pharmacology, Pharmacokinetics, and Toxicity of Fritillariae Cirrhosae Bulbus

Ting Chen, Furong Zhong, Cheng Yao, Jia Chen, Yiqing Xiang, Jijing Dong, Zhuyun Yan, Yuntong Ma and Valeria Sulsen

Evidence-Based Complementary and Alternative Medicine, 2020, 2020
DOI: 10.1155/2020/1536534

Molecular quantification of fritillariae cirrhosae bulbus and its adulterants

Ziyi Liu, Yifei Pei, Tiezhu Chen, Zemin Yang, Wenjun Jiang, Xue Feng and Xiwen Li

Chin Med, 2024, 19
DOI: 10.1186/s13020-024-01010-z

Characterization and identification of steroidal alkaloids in Fritillaria species using liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry

Jian-Liang Zhou, Gui-Zhong Xin, Zi-Qi Shi, Mei-Ting Ren, Lian-Wen Qi, Hui-Jun Li and Ping Li

Journal of Chromatography A, 2010, 1217, 7109
DOI: 10.1016/j.chroma.2010.09.019

Quantitative Analysis of Steroidal Glycosides in Different Organs of Easter Lily (Lilium longiflorum Thunb.) by LC-MS/MS

John P. Munafo and Thomas J. Gianfagna

J. Agric. Food Chem., 2011, 59, 995
DOI: 10.1021/jf1036454

LC-MS-MS Method for the Determination of Protoveratrine A in Rat Plasma

Hai-Yun Li, Wen Xu, Hui-Liang Li, Wei-Dong Zhang and Li-Wei Hu

Chroma, 2009, 69, 523
DOI: 10.1365/s10337-008-0936-4

Identification and characterization ofin vitroandin vivometabolites of steroidal alkaloid veratramine

Chunming Lyu, Wenbin Zhou, Yufeng Zhang, Shen Zhang, Fang Kou, Hai Wei, Ning Zhang and Zhong Zuo

Biopharm & Drug Disp, 2015, 36, 308
DOI: 10.1002/bdd.1942

Enantioselective Total Synthesis of (+)-Heilonine

Kyle J. Cassaidy and Viresh H. Rawal

J. Am. Chem. Soc., 2021, 143, 16394
DOI: 10.1021/jacs.1c08756

Isosteroidal alkaloids of Fritillaria taipaiensis and their implication to Alzheimer's disease: Isolation, structural elucidation and biological activity

An-Wen Wang, Yu-Ming Liu, Ming-Ming Zhu and Rui-Xue Ma

Phytochemistry, 2022, 201, 113279
DOI: 10.1016/j.phytochem.2022.113279

Optimization of Supercritical Fluid Extraction of Total Alkaloids, Peimisine, Peimine and Peiminine from the Bulb of Fritillaria thunbergii Miq, and Evaluation of Antioxidant Activities of the Extracts

Xiao Ruan, Li Yang, Wen-Xia Cui, Men-Xing Zhang, Zhao-Hui Li, Ben Liu and Qiang Wang

Materials, 2016, 9, 524
DOI: 10.3390/ma9070524

Metabolomics Study of Cultivated Bulbus Fritillariae Cirrhosae at Different Growth Stages using UHPLC‐QTOF‐MS Coupled with Multivariate Data Analysis

Zhao Geng, YiFei Liu, Yan Gou, QinMei Zhou, ChengJun He, Li Guo, Juan Zhou and Liang Xiong

Phytochemical Analysis, 2018, 29, 290
DOI: 10.1002/pca.2742

Incompatible effects of Panax ginseng and Veratrum nigrum on estrogen decline in rats using metabolomics and gut microbiota

He Lin, Zhongying Liu, Zhiqiang Liu and Zhe Lin

Journal of Pharmaceutical and Biomedical Analysis, 2022, 208, 114442
DOI: 10.1016/j.jpba.2021.114442

Anti-inflammatory and antioxidant properties of jervine, a sterodial alkaloid from rhizomes of Veratrum album

Fadime Atalay Dumlu, Tuba Aydin, Fehmi Odabasoglu, Ozlem Aydin Berktas, Zerrin Kutlu, Huseyin Serkan Erol, Mesut B. Halici, Elif Cadirci and Ahmet Cakir

Phytomedicine, 2019, 55, 191
DOI: 10.1016/j.phymed.2018.06.035

Diagnostic fragmentation‐assisted mass spectral networking coupled with in silico dereplication for deep annotation of steroidal alkaloids in medicinal Fritillariae Bulbus

Feng‐Jie Liu, Yan Jiang, Ping Li, Yang‐Dan Liu, Gui‐Zhong Xin, Zhong‐Ping Yao and Hui‐Jun Li

J Mass Spectrom, 2020, 55
DOI: 10.1002/jms.4528

Chemical profiling of Fritillariae thunbergii Miq prepared by different processing methods reveals two new quality markers: Zhebeininoside and imperialine-3-β-D-glucoside

Yu-Hua Shi, Qin-Wei Huang, She-Min Zhu, Yue-Mei Zhou, Li-Jiang Zhang, Wen-Kang Huang, Jin-Jin Shao, Jian-Liang Zhou and Wen-Ting Zhang

Journal of Ethnopharmacology, 2022, 283, 114670
DOI: 10.1016/j.jep.2021.114670

A Review on the Composition and Biosynthesis of Alkaloids and on the Taxonomy, Domestication, and Cultivation of Medicinal Fritillaria Species

Aili Qu, Qingfei Wu, Jiahao Su, Chengyuan Li, Li Yang, Zhi’an Wang, Zhonghua Wang, Zhaohui Li, Xiao Ruan, Yingxian Zhao and Qiang Wang

Agronomy, 2022, 12, 1844
DOI: 10.3390/agronomy12081844

Identification of Veratrum Species in Pimacao Based on ITS2 Sequences and Steroidal Alkaloids by a Pseudo-Targeted Metabolomics Method

Qinwei Lu, Shuaiyao Wang, Zili Yin, Qinsheng Chen, Xingchao He, Qi Wang, Qingyu Hu, Yu Gu, Huiru Tang and Hui Xie

Front. Plant Sci., 2022, 13
DOI: 10.3389/fpls.2022.831562

Cevanine-type steroidal alkaloids from the bulbs of Fritillaria cirrhosa D. Don

Hui-wen Dong, Shu-hui Wang, Tse Wai Ming, Shao-bing Fu, Yun-hu Zhang, Jia-wei Li, Qing-ying Zhang, Peng-fei Tu and Hong Liang

Phytochemistry, 2024, 224, 114140
DOI: 10.1016/j.phytochem.2024.114140

Capillary electrophoresis of phytochemical substances in herbal drugs and medicinal plants

Roberto Gotti

Journal of Pharmaceutical and Biomedical Analysis, 2011, 55, 775
DOI: 10.1016/j.jpba.2010.11.041

Hydroethanolic Extract of Fritillariae thunbergii Bulbus Alleviates Dextran Sulfate Sodium-Induced Ulcerative Colitis by Enhancing Intestinal Barrier Integrity

Ami Lee, You Chul Chung, Kwang-Youn Kim, Chan Ho Jang, Kwang Hoon Song and Youn-Hwan Hwang

Nutrients, 2023, 15, 2810
DOI: 10.3390/nu15122810

Phytochemical profiling of medicinal isosteroidal alkaloids of Iranian Fritillaria spp. (Liliaceae)

Mahmoud Kiani, Fatemeh Sefidkon, Alireza Babaei and Mohamad Reza Naghavi

Industrial Crops and Products, 2015, 70, 451
DOI: 10.1016/j.indcrop.2015.03.064

Comparison and evaluation of antimuscarinic and anti-inflammatory effects of five Bulbus fritillariae species based on UPLC-Q/TOF integrated dual-luciferase reporter assay, PCA and ANN analysis

Mengge Zhou, Xiaoyao Ma, Guoyu Ding, Zengyong Wang, Dan Liu, Yongling Tong, Hong Zhou, Jie Gao, Yuanyuan Hou, Min Jiang and Gang Bai

Journal of Chromatography B, 2017, 1041-1042, 60
DOI: 10.1016/j.jchromb.2016.12.012

Steroidal alkaloids from the bulbs of Fritillaria delavayi Franch. (Liliaceae)

Xin-Wei Cao, Si-Bao Chen, Jun Li, Pei-Gen Xiao and Shi-Lin Chen

Biochemical Systematics and Ecology, 2008, 36, 665
DOI: 10.1016/j.bse.2008.05.002

Copper‐Catalyzed Trifluoromethylation and Bicyclizations of 1,7‐Enynes Leading to Fused Polycycles

Qiang Wang, Hongjian Song, Yuxiu Liu, Haibin Song and Qingmin Wang

Adv Synth Catal, 2016, 358, 3435
DOI: 10.1002/adsc.201600500

Transcriptome analysis reveals candidate genes related to steroid alkaloid biosynthesis in Fritillaria anhuiensis

Tingyu Shan, Yuanyuan Shi, Jingyao Xu, Liqiang Zhao, Yijia Tao and Jiawen Wu

Physiologia Plantarum, 2022, 174
DOI: 10.1111/ppl.13755

Two New Steroidal Alkaloids from Veratrum nigrum L.

Bin Wang, Wei‐Dong Zhang, Yun‐Heng Shen, Jian Tang, Chuan Zhang, Run‐hui Liu, Min Lin and Hui‐Liang Li

Helvetica Chimica Acta, 2008, 91, 244
DOI: 10.1002/hlca.200890030

A Concise Account of Various Approaches for Stereoselective Construction of the C-20(H) Stereogenic Center in Steroid Side Chain

Bapurao B. Shingate and Braja G. Hazra

Chem. Rev., 2014, 114, 6349
DOI: 10.1021/cr4004083

Effect of Veratrum maackii on Testosterone Propionate-Induced Benign Prostatic Hyperplasia in Rats

Hee-Seon Park, Chang-Seob Seo, Charith UB Wijerathne, Hye-Yun Jeong, Og-Sung Moon, Young-Won Seo, Young-Suk Won, Hwa-Young Son, Jong-Hwan Lim and Hyo-Jung Kwun

Biological & Pharmaceutical Bulletin, 2019, 42, 1
DOI: 10.1248/bpb.b18-00313

Research progress on the analysis of active ingredients and elements in Fritillaria ussuriensis Bulbus

Rong-Can WANG, Xin-Yi WANG, Yong-Fei QIAO and Ya-Li LI

Chinese Journal of Analytical Chemistry, 2023, 51, 100192
DOI: 10.1016/j.cjac.2022.100192

Traditional uses, phytochemistry and pharmacology of genus Fritillaria—a review

Ishrat Rashid and Ubaid Yaqoob

Bull Natl Res Cent, 2021, 45
DOI: 10.1186/s42269-021-00577-z

Chemical markers for the quality control of herbal medicines: an overview

Songlin Li, Quanbin Han, Chunfeng Qiao, Jingzheng Song, Chuen Lung Cheng and Hongxi Xu

Chin Med, 2008, 3
DOI: 10.1186/1749-8546-3-7

Fritillaria cinsinin ve bu cinsin bir üyesi olan Aygül lalesi’nin (Fritillaria eduardii) dünü, bugünü ve yarını

Daniel KİMSANALİEV, Sevgi MARAKLI and Yilmaz KAYA

International Journal of Life Sciences and Biotechnology, 2022, 5, 627
DOI: 10.38001/ijlsb.1121393

Identification of genes involved in steroid alkaloid biosynthesis in Fritillaria imperialis via de novo transcriptomics

Mahsa Eshaghi, Behrouz Shiran, Hossein Fallahi, Rudabeh Ravash and Bojana Banović Đeri

Genomics, 2019, 111, 1360
DOI: 10.1016/j.ygeno.2018.09.008

Identification of candidate genes involved in steroidal alkaloids biosynthesis in organ-specific transcriptomes of Veratrum nigrum L.

Magdalena Szeliga, Joanna Ciura, Michalina Grzesik and Mirosław Tyrka

Gene, 2019, 712, 143962
DOI: 10.1016/j.gene.2019.143962

Steroidal alkaloids from Veratrum nigrum

Wei Li, Lishu Wang, Daqing Zhao and Yonghong Liu

Chem Nat Compd, 2012, 48, 919
DOI: 10.1007/s10600-012-0426-7

Multicomponent approach to the alkaloid-type 2-aza-7-oxabicyclo[4.3.0]nonane framework

Lorenzo Sonaglia, Luca Banfi, Renata Riva and Andrea Basso

Tetrahedron Letters, 2012, 53, 6516
DOI: 10.1016/j.tetlet.2012.09.076

Real-time fluorescence and colorimetric identification of bulbus fritillariae using recombinase assisted loop-mediated isothermal DNA amplification (RALA)

Yinghua Wei, Sheng Ding, Gangyi Chen, Juan Dong, Feng Du, Xin Huang, Xin Cui, Rong Chen and Zhuo Tang

Front. Plant Sci., 2022, 13
DOI: 10.3389/fpls.2022.948879

Asymmetric Synthesis of Cyclopamine, a Hedgehog (Hh) Signaling Pathway Inhibitor

Hao Shao, Wenheng Liu, Muhan Liu, Haibing He, Qi-Lin Zhou, Shou-Fei Zhu and Shuanhu Gao

J. Am. Chem. Soc., 2023, 145, 25086
DOI: 10.1021/jacs.3c10362

Transcriptome Analysis of CYP450 Family Members in Fritillaria cirrhosa D. Don and Profiling of Key CYP450s Related to Isosteroidal Alkaloid Biosynthesis

Rui Li, Maotao Xiao, Jian Li, Qi Zhao, Mingcheng Wang and Ziwei Zhu

Genes, 2023, 14, 219
DOI: 10.3390/genes14010219

UPLC-IM-Q-TOF-MSbased biochemometric approach for the identification of insecticidal markers in Fritillaria cirrhosa D. Don and elucidation of their insecticidal action

Prateek Singh Bora, Himanshi Gupta, Urvashi, Upendra Sharma and S.G.Eswara Reddy

Microchemical Journal, 2025, 208, 112620
DOI: 10.1016/j.microc.2024.112620

Medicinal history of North American Veratrum

Christopher M. Chandler and Owen M. McDougal

Phytochem Rev, 2014, 13, 671
DOI: 10.1007/s11101-013-9328-y

In-depth exploration and comparison of chemical constituents from two Lilium species through offline two-dimensional liquid chromatography combined with multimode acquisition of high-resolution mass spectrometry

Xingdong Wu, Jinjun Hou, Zijia Zhang, Lingmin Chen, Hui Ni, Yong Qian, Wenyong Wu, Huali Long, Linlin Zhang, FeiFei Li, Min Lei, Yong Huang, Dean Guo and Wanying Wu

Journal of Chromatography A, 2022, 1670, 462980
DOI: 10.1016/j.chroma.2022.462980

Research Progress on Antibacterial Activities and Mechanisms of Natural Alkaloids: A Review

Yumei Yan, Xing Li, Chunhong Zhang, Lijuan Lv, Bing Gao and Minhui Li

Antibiotics, 2021, 10, 318
DOI: 10.3390/antibiotics10030318

Steroidal alkaloids from Veratrum schindleri and Veratrum maackii

Hai-Qiang Huang, Hui-Liang Li, Jian Tang, Bin Wang, Yi-Feng Lv, Yun-Heng Shen and Wei-Dong Zhang

Biochemical Systematics and Ecology, 2008, 36, 430
DOI: 10.1016/j.bse.2007.09.006

Veratrum parviflorum: An Underexplored Source for Bioactive Steroidal Alkaloids

Jared T. Seale and Owen M. McDougal

Molecules, 2022, 27, 5349
DOI: 10.3390/molecules27165349

Convergent Total Synthesis of (−)-Cyclopamine

Manolis Sofiadis, Dongmin Xu, Anthony J. Rodriguez, Benedikt Nissl, Sebastian Clementson, Nadia Nasser Petersen and Phil S. Baran

J. Am. Chem. Soc., 2023, 145, 21760
DOI: 10.1021/jacs.3c09085

Herbal medicines and chemotherapy induced peripheral neuropathy (CIPN): A critical literature review

Janet Schloss, Maree Colosimo and Luis Vitetta

Critical Reviews in Food Science and Nutrition, 2017, 57, 1107
DOI: 10.1080/10408398.2014.889081

Revealing active components and action mechanism of Fritillariae Bulbus against non-small cell lung cancer through spectrum-effect relationship and proteomics

Feng-Jie Liu, Xu-Yan Chen, Jiao Yang, Zhen Zhao, Qiao-Lei Wang, Ping Li, Yan Jiang and Hui-Jun Li

Phytomedicine, 2023, 110, 154635
DOI: 10.1016/j.phymed.2022.154635

Bioassay-guided fractionation of extracts from Easter lily (Lilium longiflorum) flowers reveals unprecedented structural variability of steroidal glycoalkaloids

Silvio Uhlig, Fozia Hussain and Helene Wisløff

Toxicon, 2014, 92, 42
DOI: 10.1016/j.toxicon.2014.09.004

Steroidal alkaloids and their glycosides from the bulbs of Fritillaria unibracteata

Shu-Hui Wang, Hong Liang, Yu-Qi Wang, Wai-Gaun Kathy TSE, Hui-Wen Dong, Tie-Chui Yang, Yun-Hu Zhang, Ke-Wu Zeng and Peng-Fei Tu

Steroids, 2022, 181, 108977
DOI: 10.1016/j.steroids.2022.108977

Garlic bioactive substances and their therapeutic applications for improving human health: a comprehensive review

Mohamed T. El-Saadony, Ahmed M. Saad, Sameh A. Korma, Heba M. Salem, Taia A. Abd El-Mageed, Samar Sami Alkafaas, Mohamed I. Elsalahaty, Sara Samy Elkafas, Walid F. A. Mosa, Ahmed Ezzat Ahmed, Betty T. Mathew, Noor A. Albastaki, Aysha A. Alkuwaiti, Marawan K. El-Tarabily, Synan F. AbuQamar, Khaled A. El-Tarabily and Salam A. Ibrahim

Front. Immunol., 2024, 15
DOI: 10.3389/fimmu.2024.1277074

Antimicrobial, antioxidant and essential oil studies on Veratrum album L. (Melanthiaceae)

Pelin Yılmaz Sancar, Şule İnci, Azize Demirpolat, Sevda Kırbağ and Şemsettin Civelek

International Journal of Secondary Metabolite, 2024, 11, 255
DOI: 10.21448/ijsm.1336752

N‐substituted Piperazinopyridylsteroid Derivatives as Abiraterone Analogues Inhibit Growth and Induce Pro‐apoptosis in Human Hormone‐independent Prostate Cancer Cell Lines

Dominique Brossard, Ying Zhang, Shozeb M. Haider, Miriam Sgobba, Mohamed Khalid, Rémi Legay, Martine Duterque‐Coquillaud, Philippe Galera, Sylvain Rault, Patrick Dallemagne, Safa Moslemi and Laïla El Kihel

Chem Biol Drug Des, 2013, 82, 620
DOI: 10.1111/cbdd.12195

Capturing the Geoherbalism Differentiation in Wild Paris polyphylla var. yunnanensis Raw Materials through the Application of Multispectral Information Fusion Combined with Chemometrics

Yuanzhong Wang, Yan Li and Jinyu Zhang

ACS Omega, 2019, 4, 18820
DOI: 10.1021/acsomega.9b02818

Risk assessment of glycoalkaloids in feed and food, in particular in potatoes and potato‐derived products

Dieter Schrenk, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Jesús del Mazo, Christer Hogstrand, Laurentius (Ron) Hoogenboom, Jean‐Charles Leblanc, Carlo Stefano Nebbia, Elsa Nielsen, Evangelia Ntzani, Annette Petersen, Salomon Sand, Tanja Schwerdtle, Christiane Vleminckx, Heather Wallace, Leon Brimer, Bruce Cottrill, Birgit Dusemund, Patrick Mulder, Günter Vollmer, Marco Binaglia, Luisa Ramos Bordajandi, Francesca Riolo, Ruth Roldán‐Torres and Bettina Grasl‐Kraupp

EFS2, 2020, 18
DOI: 10.2903/j.efsa.2020.6222

Global detection and semi‐quantification of Fritillaria alkaloids in Fritillariae Ussuriensis Bulbus by a non‐targeted multiple reaction monitoring approach

Li Wang, Zhong Ping Yao, Ping Li, Si‐Bao Chen, Pui‐Kin So, Zi‐Qi Shi, Bin Hu, Li‐Fang Liu and Gui‐Zhong Xin

J of Separation Science, 2016, 39, 287
DOI: 10.1002/jssc.201500880

Mucolytic Activity Test of Shallot Extract (Allium Ascalonicum L) by in Vitro

D A Deswati, M A Dhina and S R Mubaroq

IOP Conf. Ser.: Mater. Sci. Eng., 2018, 288, 012141
DOI: 10.1088/1757-899X/288/1/012141

Synthesis of Demissidine Analogues from Tigogenin via Imine Intermediates

Agnieszka Wojtkielewicz, Urszula Kiełczewska, Aneta Baj and Jacek W. Morzycki

IJMS, 2021, 22, 10879
DOI: 10.3390/ijms221910879

Metabolite Profiling and Anti-Inflammatory Activities of Fritillaria cirrhosa D. Don Bulbs Derived from Tissue Culture

Yu Wang, Jiamin Liu, Enhao Zhang, Yixi Yang, Qiuxia Lu, Ziwei Zhu and Rui Li

Molecules, 2025, 30, 623
DOI: 10.3390/molecules30030623

Analysis of metabolic variation and galanthamine content in Narcissus bulbs by 1H NMR

Andrea Lubbe, Barbora Pomahačová, Young Hae Choi and Robert Verpoorte

Phytochemical Analysis, 2010, 21, 66
DOI: 10.1002/pca.1157

Steroidal alkaloids from the roots of Veratrum stenophyllum

Zhong-Shun Zhou, Yang-Yang Liu, Yan-Yan Zhu, Bin-Yuan Hu, Ying-Jie He and Xiao-Dong Luo

Fitoterapia, 2023, 166, 105464
DOI: 10.1016/j.fitote.2023.105464

TIPdb-3D: the three-dimensional structure database of phytochemicals from Taiwan indigenous plants

C.-W. Tung, Y.-C. Lin, H.-S. Chang, C.-C. Wang, I.-S. Chen, J.-L. Jheng and J.-H. Li

Database, 2014, 2014, bau055
DOI: 10.1093/database/bau055

Two new steroidal alkaloids from the rhizomes of Veratrum nigrum L. and their anti-TYLCV activity

Yu-Lin Li, Yu Zhang, Ping-Zhi Zhao, Zhan-Xing Hu, Yu-Cheng Gu, Jian Ye and Xiao-Jiang Hao

Fitoterapia, 2020, 147, 104731
DOI: 10.1016/j.fitote.2020.104731

Separation and Preparation of Five Cyclopamine Analogs from Rhizomes ofVeratrum oxysepalumTurcz. by Two-Step High-Speed Counter-Current Chromatography

Yue Yu, Huijun Li and Yan Jiang

Separation Science and Technology, 2014, 49, 2748
DOI: 10.1080/01496395.2014.942744

A new steroidal alkaloid from Fritillaria michailovskyi Fomin

Yan Wang, Muhammad Aamer, Meral Aslay, Bilge Sener, Farooq-Ahmad Khan, Atia-tul Wahab, Atta-ur Rahman and Muhammad Iqbal Choudhary

Natural Product Research, 2022, 36, 361
DOI: 10.1080/14786419.2020.1786828

Isosteroidal alkaloids from the bulbs of Fritillaria tortifolia

Zhu Hu, Jian-Fa Zong, Abulimiti Yili, Mei-Hua Yu, Haji Akber Aisa and Ai-Jun Hou

Fitoterapia, 2018, 131, 112
DOI: 10.1016/j.fitote.2018.10.019

A convenient and efficient one-pot conversion of peimisine into cyclopamine

Shu-Yan Zheng, Hong-Sheng Tan, Jian-Sheng Tao and Zheng-Wu Shen

Fitoterapia, 2012, 83, 1238
DOI: 10.1016/j.fitote.2012.06.010

Chemistry and bioactivities of natural steroidal alkaloids

Mei-Ling Xiang, Bin-Yuan Hu, Zi-Heng Qi, Xiao-Na Wang, Tian-Zhen Xie, Zhao-Jie Wang, Dan-Yu Ma, Qi Zeng and Xiao-Dong Luo

Nat. Prod. Bioprospect., 2022, 12
DOI: 10.1007/s13659-022-00345-0

Frititaipaines A−O, undescribed cevanine-type isosteroidal alkaloids from the bulbs of Fritillaria taipaiensis and their anti-neuroinflammatory and AChE inhibitory activities

Zai-Long Huang, En-Ke Qu, Lan-Run Yang, Rui Luo, Yan-Ni Liang, Shi-Jun Liu, Yuan-Zhen Xu and Dong-Bo Zhang

Phytochemistry, 2025, 239, 114582
DOI: 10.1016/j.phytochem.2025.114582

Phytochemical and biological research of Fritillaria Medicine Resources

Da-Cheng HAO, Xiao-Jie GU, Pei-Gen XIAO and Yong PENG

Chinese Journal of Natural Medicines, 2013, 11, 330
DOI: 10.1016/S1875-5364(13)60050-3

Potent anti-inflammatory and analgesic steroidal alkaloids from Veratrum taliense

Qiong Li, Kun-Xian Yang, Yun-Li Zhao, Xu-Jie Qin, Xing-Wei Yang, Lu Liu, Ya-Ping Liu and Xiao-Dong Luo

Journal of Ethnopharmacology, 2016, 179, 274
DOI: 10.1016/j.jep.2015.12.059

Peimine, a main active ingredient of Fritillaria, exhibits anti-inflammatory and pain suppression properties at the cellular level

Jianwei Xu, Wei Zhao, Lanying Pan, Ailian Zhang, Qingmao Chen, Kai Xu, Haiyin Lu and Yuan Chen

Fitoterapia, 2016, 111, 1
DOI: 10.1016/j.fitote.2016.03.018

Lignan glycosides from Fritillaria verticillata Willd. and their anti-inflammatory activities

Nan Ma, Si-Xuan Liu, Yong-Fu Li, Fu-Hua Deng, Yi-Hui Yang, Chang Li and Yue-Hu Pei

Fitoterapia, 2023, 168, 105553
DOI: 10.1016/j.fitote.2023.105553

Stereoselective Synthesis of (−)-Verazine and Congeners via a Cascade Ring-Switching Process of Furostan-26-acid

Yun Wang, Yong Shi, Wei-Sheng Tian, Pei Tang, Chunlin Zhuang and Fen-Er Chen

Org. Lett., 2020, 22, 2761
DOI: 10.1021/acs.orglett.0c00747

Discovery of steroidal alkaloid glycosides from the bulbs of Fritillaria unibracteata with anti-inflammatory activities using an in vivo zebrafish model

Shu-Hui Wang, Yu-Qi Wang, Tian Lv, Xiao-Ni Ai, Wai-Gaun Kathy Tse, Hong Liang, Tie-Chui Yang, Qing-Ying Zhang and Peng-Fei Tu

Phytochemistry, 2022, 204, 113437
DOI: 10.1016/j.phytochem.2022.113437

Analysis of impact damage of Fritillaria ussuriensis Maxim using a free drop experimental study

Jiang Song, Yaoshen Wang, Shuai Tian, Xingrong Sun and Shujuan Yi

International Journal of Food Properties, 2023, 26, 1374
DOI: 10.1080/10942912.2023.2218065

Peimine inhibits hERG potassium channels through the channel inactivation states

Liandi Kan, Wei Zhao, Lanying Pan, Jianwei Xu, Qingmao Chen, Kai Xu, Liping Xiao and Yuan Chen

Biomedicine & Pharmacotherapy, 2017, 89, 838
DOI: 10.1016/j.biopha.2017.02.070

Chemical constituents from Fritillaria anhuiensis

Qingyao Shou, Hans Wohlmuth, Xiaoxiang He, Lei Liu and Zhengwu Shen

Biochemical Systematics and Ecology, 2012, 45, 16
DOI: 10.1016/j.bse.2012.07.002

Metabolite and expression profiling of steroidal alkaloids in wild tissues compared to bulb derived in vitro cultures of Fritillaria roylei – High value critically endangered Himalayan medicinal herb

Pankaj Kumar, Mahinder Partap, Ashrita, Divya Rana, Pawan Kumar and Ashish R. Warghat

Industrial Crops and Products, 2020, 145, 111945
DOI: 10.1016/j.indcrop.2019.111945

A New UPLC-MS/MS Method Validated for Quantification of Jervine in Rat Plasma and the Study of Its Pharmacokinetics in Rats

Lianguo Chen, Qinghua Weng and Jianshe Ma

Journal of Analytical Methods in Chemistry, 2019, 2019, 1
DOI: 10.1155/2019/5163625

Simultaneous Determination and Pharmacokinetics of Peimine and Peiminine in Beagle Dog Plasma by UPLC-MS/MS after the Oral Administration of Fritillariae ussuriensis Maxim and Fritillariae thunbergii Miq Powder

Zhibin Wang, Feng Cao, Yajun Chen, Zhenqiu Tang and Zhenyue Wang

Molecules, 2018, 23, 1573
DOI: 10.3390/molecules23071573

Isosteroidal Alkaloids from Fritillaria verticillata Willd. and Their NMR Spectroscopic Characteristics

Nan Ma, Ya‐Jing Wang, Gang Chen, Chu‐Ren Meng, Chun‐Lin Guo, Yong‐Fu Lu, Si‐Yang Dai, Si‐Xuan Liu, Yong‐Fu Li, Chang Li and Yue‐Hu Pei

Chin. J. Chem., 2022, 40, 1945
DOI: 10.1002/cjoc.202200220

Untargeted metabolomics coupled with chemometric analysis reveals species-specific steroidal alkaloids for the authentication of medicinal Fritillariae Bulbus and relevant products

Feng-Jie Liu, Yan Jiang, Ping Li, Yang-Dan Liu, Zhong-Ping Yao, Gui-Zhong Xin and Hui-Jun Li

Journal of Chromatography A, 2020, 1612, 460630
DOI: 10.1016/j.chroma.2019.460630

Cirrhosinones A-H, 24-hydroxy cevanine-type alkaloids from Fritillaria cirrhosa

Huiwen Dong, Yunhu Zhang, Tse Wai Ming, Shuhui Wang, Jiawei Li, Shaobing Fu, Qingying Zhang, Kewu Zeng, Pengfei Tu and Hong Liang

Phytochemistry, 2022, 197, 113129
DOI: 10.1016/j.phytochem.2022.113129

Tetraose steroidal glycoalkaloids from potato provide resistance against Alternaria solani and Colorado potato beetle

Pieter J Wolters, Doret Wouters, Yury M Tikunov, Shimlal Ayilalath, Linda P Kodde, Miriam F Strijker, Lotte Caarls, Richard GF Visser and Vivianne GAA Vleeshouwers

eLife, 2023, 12
DOI: 10.7554/eLife.87135

Network Pharmacology and Experimental Verification Reveal the Regulatory Mechanism of Chuanbeimu in Treating Chronic Obstructive Pulmonary Disease

Meilan Xian, Jiaoyuan Xu, Yamei Zheng, Lei Zhang, Jie Zhao, Jie Chen, Siguang Li, Lingsang Lin, Yi Zhong, Zehua Yang, Tian Xie, Linhui Huang and Yipeng Ding

COPD, 2024, Volume 19, 799
DOI: 10.2147/COPD.S442191

Veramadines A and B, New Steroidal Alkaloids from Veratrum maackii var. japonicum

Naonobu Tanaka, Shohei Suto and Jun'ichi Kobayashi

Chem. Pharm. Bull., 2011, 59, 909
DOI: 10.1248/cpb.59.909

Histochemical Localization of Alkaloids in the Bulbs of In Vitro-Regenerated Snake’s Head Fritillary (Fritillaria meleagris L.): The Effect of a Temperature Regime

Marija Marković, Milana Trifunović-Momčilov, Olga Radulović, Danijela Paunović, Dragana Antonić Reljin, Slađana Jevremović and Branka Uzelac

Horticulturae, 2023, 10, 17
DOI: 10.3390/horticulturae10010017

Discovery of a potent C20-oxime pachysandra alkaloid analogue promising for treatment of hepatocellular carcinoma

Chen-Liang Zhao, Wen-Wen Zhang, Jin-Feng Zhao, Jiang-Hai Ye, Peng Wei, Juan Zou and Kang He

Bioorganic & Medicinal Chemistry, 2025, 129, 118324
DOI: 10.1016/j.bmc.2025.118324

Exploration of new 3α-pregnenolone ester analogues via Mitsunobu reaction, their anti-HIV activity and molecular modeling study

Kuthair Mohammed Mahdi, Nabeel Abed Abdul-Reda and Najim Aboud Al-Masoudi

Eur. J. Chem., 2015, 6, 1
DOI: 10.5155/eurjchem.6.1.1-7.1139

Pharmacokinetics and tissue distribution study of hupehenenine in rats: A novel isosteroid alkaloid isolated from Bulbus Hupehensis Fritillariae

Qinyan Zhang, Dongguo Li, Bihua Ma, Xueyan Wang, Junyi Yang, Donglin Chen and Liming Ye

Biomedical Chromatography, 2021, 35
DOI: 10.1002/bmc.5122

Antinociceptive Efficacy of Verticinone in Murine Models of Inflammatory Pain and Paclitaxel Induced Neuropathic Pain

Fangzhou Xu, Shongzhou Xu, Lijun Wang, Chuntao Chen, Xueqing Zhou, Yuzhen Lu and Huihui Zhang

Biological & Pharmaceutical Bulletin, 2011, 34, 1377
DOI: 10.1248/bpb.34.1377

Metabolomic approach for rapid differentiation of Fritillaria bulbs by matrix-assisted laser desorption/ionization mass spectrometry and multivariate statistical analysis

Ze Wang, Hanyi Xie, Juan Ren, Yang Chen, Xiaofei Li, Xiangfeng Chen and Tak-Wah Dominic Chan

Journal of Pharmaceutical and Biomedical Analysis, 2020, 185, 113177
DOI: 10.1016/j.jpba.2020.113177

Solid acids assisted matrix solid‐phase dispersion microextraction of alkaloids by capillary electrophoresis coupled with quadrupole time‐of‐flight mass spectrometry

Qiu‐Yan Wang, Xin Dong, Juan Yang, Xiao‐Ting Zhen, Li‐Hong Ye, Chu Chu, Bin Wang, Yu‐Han Hu, Hui Zheng and Jun Cao

J of Separation Science, 2019, 42, 3579
DOI: 10.1002/jssc.201900647

Genome-wide transcriptional analysis unveils the molecular basis of organ-specific expression of isosteroidal alkaloids biosynthesis in critically endangered Fritillaria roylei Hook

Balraj Sharma, Romit Seth, Sapna Thakur, Rajni Parmar, Mamta Masand, Amna Devi, Gopal Singh, Praveen Dhyani, Shruti Choudhary and Ram Kumar Sharma

Phytochemistry, 2021, 187, 112772
DOI: 10.1016/j.phytochem.2021.112772