Issue 42, 2013
From the journal:

Chemical Communications

A Pt(ii)–Dip complex stabilizes parallel c-myc G-quadruplex†

Jintao Wang,a   Kaihui Lu,a   Shuguang Xuan,a   Zaozhen Toh,a   Dawei Zhang*a  and  Fangwei Shao*a  

* Corresponding authors

a Division of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, Singapore
E-mail: fwshao@ntu.edu.sg, zhangdw@ntu.edu.sg
Fax: +65 6791-1961
Tel: +65 6592-2511

Abstract

A new G-quadruplex (GQ) stabilizer, [Pt(Dip)2](PF6)2 (Dip: 4,7-diphenyl-1,10-phenanthroline), is prepared by the microwave irradiation method. The complex can highly stabilize G-quadruplex, but has negligible interactions with duplex DNA. Aromatic anchors on the polypyridyl ligands bestow the stabilizer with a high binding preference towards parallel GQ.

Graphical abstract: A Pt(ii)–Dip complex stabilizes parallel c-myc G-quadruplex

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Article information

DOI
https://doi.org/10.1039/C3CC40868J
Article type
Communication
Submitted
01 helmi 2013
Accepted
02 huhti 2013
First published
03 huhti 2013

Chem. Commun., 2013,49, 4758-4760

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A Pt(II)–Dip complex stabilizes parallel c-myc G-quadruplex

J. Wang, K. Lu, S. Xuan, Z. Toh, D. Zhang and F. Shao, Chem. Commun., 2013, 49, 4758 DOI: 10.1039/C3CC40868J

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