Issue 56, 2020

Dielectrophoretic separation of platelet cells in a microfluidic channel and optimization with fuzzy logic

Abstract

It is the aim to develop optimization techniques to separate platelets from Red Blood Cells (RBCs) after designing and analyzing a microfluidic chip in this study. RBCs and platelets are present in the blood, but some healthcare applications require either platelets or RBCs. Therefore, it is necessary to separate platelets from RBCs. In this study, the design and analysis of the microfluidic chip were carried out with the Comsol Multiphysics program. Since the separation of platelets and RBCs in the blood flowing from a channel is provided by the Dielectrophoretic (DEP) force technique, the DEP force feature was given importance in the design of microfluidic channels. Much data was obtained while designing and analyzing processes. It has been observed that the voltage applied to the microfluidic channel and the inlet velocity of the blood affect the fluidic velocity and pressure along the microfluidic channel. It was also understood that the separation of platelets from RBCs depends on input data. Input and output data were analyzed in the Comsol Multiphysics program, and the optimization of the microfluidic chip was realized with the Matlab-Fuzzy Logic program. In order for the platelets to be separated from the RBCs, the optimum voltage to be applied to the microfluidic chip should be in the range of 4–6 V and the inlet velocity of the blood in the range of 800–900 μm s−1. When these input values are given, the maximum pressure affecting the microfluidic outlet channel is 10–12 Pa, and the maximum velocity is in the range of 1.25–1.5 mm s−1. These results are the optimum values required to separate platelets from RBCs.

Graphical abstract: Dielectrophoretic separation of platelet cells in a microfluidic channel and optimization with fuzzy logic

Article information

Article type
Paper
Submitted
19 heinä 2020
Accepted
29 elo 2020
First published
11 syys 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 33731-33738

Dielectrophoretic separation of platelet cells in a microfluidic channel and optimization with fuzzy logic

I. Ertugrul and O. Ulkir, RSC Adv., 2020, 10, 33731 DOI: 10.1039/D0RA06271E

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements