Issue 11, 2019

Metabolomic profiles associated with exposure to per- and polyfluoroalkyl substances (PFASs) in aquatic environments

Abstract

Per- and polyfluoroalkyl substances (PFASs) are frequently detected in aquatic environments. Longer chained perfluoroalkyl acids (PFAAs), in particular, have been found to bioaccumulate in a broad range of aquatic biota. PFAAs have a physiochemical similarity to naturally occurring fatty acids and could potentially disrupt metabolic processes, however, there has been limited study in this area, especially in aquatic species. In this study, the associations between PFAAs and metabolite profiles were investigated in crustaceans. Eastern School Prawn (Metapenaeus macleayi) were obtained from three different locations (n = 15 per location) with similar environmental conditions but different levels of PFAA contamination. The concentrations of PFAAs, fatty acids and amino acids were analysed and differences in PFAA and metabolite profiles were evaluated. Different PFAA profiles were mirrored by significant differences in the composition of both fatty acid and amino acid profiles, indicating a potential association between PFAA concentration and the composition of metabolites in prawns. These results highlight a need for further research investigating the impacts of PFAA exposure, with the current study providing a foundation for further investigation of the relationship between PFAA bioaccumulation and organism metabolism.

Graphical abstract: Metabolomic profiles associated with exposure to per- and polyfluoroalkyl substances (PFASs) in aquatic environments

  • This article is part of the themed collection: PFAS

Supplementary files

Article information

Article type
Paper
Submitted
27 elo 2019
Accepted
17 syys 2019
First published
19 syys 2019

Environ. Sci.: Processes Impacts, 2019,21, 1980-1990

Metabolomic profiles associated with exposure to per- and polyfluoroalkyl substances (PFASs) in aquatic environments

M. D. Taylor, J. Bräunig, J. F. Mueller, M. Crompton, R. H. Dunstan and S. Nilsson, Environ. Sci.: Processes Impacts, 2019, 21, 1980 DOI: 10.1039/C9EM00394K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements