Themed collection Biomaterials Science Most Popular 2025 Articles

Theranostic hydrogels represent a groundbreaking approach for integrating therapeutic and diagnostic capabilities within a single platform, enabling real-time monitoring of wounds and precise treatment applications.

Next-generation nanocarriers integrating passive, active, and stimuli-responsive strategies offer precision therapy for colorectal cancer, improving tumor selectivity, controlled release, and translational potential.

This review revisits key properties of the extracellular matrix to be replicated in hydrogels for 3D cell culture and summarizes the interplay between hydrogel structural and mechanical properties, as well as their combined impact on cell function.

Versatile graphene oxide nanomaterials enable tumor microenvironment (TME) modulation and TME-responsive drug delivery for combinative cancer therapy.

Optimizing the physicochemical properties of engineered bone implants enhances osseointegration and promotes bone regeneration by regulating the local immune responses.

This review highlights the strategies for tuning the mechanical properties, self-healing capacity, and biodegradable performance of PU elastomers, as well as their latest applications in biomedicine, and looking forward to their future prospects.

This review discusses advancements in organ-on-a-chip models, emphasizing gut, liver, and integrated gut–liver systems. It covers their applications in disease modeling, toxicity testing, and drug screening, as well as future prospects.

Gelatin methacryloyl (GelMA) granular hydrogel scaffolds (GHS) enhance cell infiltration, modulate inflammation, and improve the quality of skin tissue repair. These findings highlight the therapeutic potential of GelMA GHS for wound healing.

A new double network hydrogel made of pullulan, dextran and alginate was developed for guided tissue repair.

Stainless steel 316L (316L SS) is frequently used in implants and medical devices because of its low cost, high mechanical strength, and adequate biocompatibility.

A rapid in situ-forming, mucoadhesive PEG hydrogel was developed, offering prolonged retention in the nasal cavity and potentially other mucosal sites for drug delivery applications.

Cu-BTC mofs embedded, tannic acid loaded 3-D polymeric hydrogel composed of gellan gum, zein for deep wound healing.

We engineered SwellMA by combining gelatin methacryloyl (GelMA) with sodium polyacrylate (SPA) to enable dynamic shape changes and enhanced performance in 4D bioprinting applications.

Identifying key physicochemical factors affecting SERS biosensing performance in 3D cell models using a library of thiol–ene photo-crosslinked plasmonic hydrogels.

Simple templating of actuators via micro-topographical patterning (STAMP) enables precisely patterning muscle fibers within engineered tissues, enabling fabrication of complex multi-oriented architectures such as a biomimetic iris.

A novel folic acid-conjugated, iron-based metal framework MIL-101 (Fe) MOF loaded with 1,8-acridinediones (DO8) was developed for targeted photodynamic therapy (PDT).

Schematic showing the development of the multifaceted VEGF-activated scaffolds to promote pro-regenerative environments for chronic wound applications.

Graphical representation of the production of MSC-Hyb LNPs via microfluidic sonication. After simultaneous rapid mixing of both phases under 30 kHz and 50 W sonication, the MSC-Hyb LNPs were formed from synthetic lipids and EV-derived material.

Zwitterionic polymer PMPC was conjugated to a DNA aptamer to enhance its therapeutic efficacy in vivo, while minimizing the recognition by anti-PEG antibodies.

3D bioprinted PLA scaffolds with curcumin-loaded lipid carriers show antimicrobial activity and promote skin regeneration, offering promise for wound healing.