The gram-scale synthesis of benzofuranyl acetic acid via a Willgerodt–Kindler rearrangement is presented. Additionally, the antifungal activity against Fusarium oxysporum was tested for ten different benzofuranyl acetic acid amides.
Benzofuran moiety is the main component of many biologically active natural and synthetic heterocycles.
Design and synthesis of novel benzofuran–pyrazole-based analogues conjugated with substituted aromatic and heterocyclic ring systems. 3d exhibited multi-kinase suppression activity against B-Raf (V600E), c-Met, Pim-1, EGFR (WT), and VEGFR-2.
The overexpression of VEGFR-2 and carbonic anhydrase IX (hCA IX), two proven therapeutic targets in aggressive malignancies, is closely associated with hypoxia-driven tumor growth.
A new series of proximicin analogues containing a benzofuran moiety as the replacement of the di-furan scaffold of the parent compound were synthesised and evaluated for their anti-proliferative activities against human glioblastoma cells U-87 MG.