Secondary metabolites are assembled by drawing off and committing some of the flux of primary metabolic building blocks to sets of enzymes that tailor the maturing scaffold.
This review analyzes advances in plant alkaloid biosynthesis (2018–2025), highlighting key challenges in stereochemical control, cyclization, and tailoring modifications, and discusses synthetic biology strategies for microbial production.
We present a concise asymmetric synthesis of (−)-Bao Gong Teng A via an Evans chiral auxiliary-controlled regio- and diastereoselective 1,3-dipolar cycloaddition between p-chlorobenzyl pyridinium salt and (R)-3-acryloyl-4-phenyloxazolidin-2-one.
This review article covers the current state of asymmetric synthetic methods for functionalized cyclohepta[b]indoles, which have attracted significant interest due to their presence in many bioactive compounds.
Katritzky's pioneering studies revealed the multifaceted cycloaddition reactivities of oxidopyridinium betaines. In this review, the follow-up research into oxidopyridinium cycloadditions and their applications are discussed.