We report an unexpected route for synthesizing pyrrole-fused dibenzoxazepines/thiazepines with high chemoselectivity via a pseudo-Joullié–Ugi reaction from cyclic imines with isocyanides and acetylenedicarboxylates under catalyst-free conditions.
An efficient visible-light-induced Staudinger [2 + 2] annulation reaction under catalyst-free conditions has been established, and tetracyclic dibenzo[b,f][1,4]oxazepine/thiazepine-fused β-lactams were synthesized with a broad substrate scope and high efficiency (37 examples, up to >99% yield).
The synthesis of dansylated (fluorescent) phenylalanine-type amino acid motifs via a C(sp3)–H arylation strategy and high-content screening against IAV infection to identify the antiviral properties of the synthesized molecules are reported.
A protocol for obtaining modified azobenzenes is reported via the Pd(II)-catalyzed C–H functionalization of carboxamides using iodoazobenzenes. It would serve as an ancillary route to the cross-coupling reaction used to obtain modified azobenzenes.
Rigidified heterocycles encompassing two dibenzo[b,f]oxazepine scaffolds and a 1,4-dihydropyrrolo[3,2-b]pyrrole core show intense blue emission and low turn-on voltage (≈3.5 V) in OLED devices.