Non-fluorinated and fluorinated alcohols are systematically investigated to elucidate the effects of the fluorination degree in alcohols on the interaction with F−. The electrostatic term plays the most significant role among the attractive terms.
QSARs developed with computed stretching vibrational frequencies and corresponding infrared intensities predict invariable pKa with increasing chain length for different per- and polyfluoroalkyl acids.
A series of mono- and bis-fluoroalkoxylated compounds of 4-aryl-pyrrolo[2,3-d]pyrimidine derivatives were synthesized by Pd-catalysed direct C–H fluoroalkoxylation in a mild, efficient and highly site selective manner.
The influence of fluoroalcohols on peptide folding was studied.
We reported a direct simple trifluoromethylthiolation reaction of various terminal alkynes using a new hypervalent trifluoromethylthio-iodine(III) reagent TFTI in a fluorinated alcohol, either hexafluoro-2-propanol or perfluoro-tert-butanol.