This review presents an overview of recent developments and trends in chiral Brønsted acid mediated rearrangement reactions. Different mechanisms and activation modes are summarized to illustrate the regio- and stereo-selectivity in the reactions.
The first asymmetric intermolecular hydrofunctionalization of ynamides with biaryl phenols catalyzed by a chiral Brønsted acid is disclosed.
This highlight demonstrates the state of the art in the field of the enantioselective merged gold/organocatalysis by leveraging the unique reactivity of each catalyst.
Chiral phosphoric acid catalysts (CPA), as important organic catalysts, exhibit excellent catalytic efficiency due to their bifunctional properties. From the perspective of catalyst design, this presents their development in recent years.
The use of olefins in the construction of cyclic compounds represents a powerful strategy for advancing the pharmaceutical industry.