Organic probes for NO-activatable biomedical imaging: NIR fluorescence, self-luminescence, and photoacoustic imaging

Weihao An, Zhongkun Wang, Qingqing Miao and Qing Li

Chem. Sci., 2025, 16, 13574
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Recent progress in small-molecule fluorescent probes for the detection of superoxide anion, nitric oxide, and peroxynitrite anion in biological systems

Yongqing Zhou, Xuan Kuang, Xiaofeng Yang, Juan Li, Xianzhe Wei, Won Jun Jang, Shan-Shan Zhang, Mei Yan and Juyoung Yoon

Chem. Sci., 2024, 15, 19669
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A de novo zwitterionic strategy of ultra-stable chemiluminescent probes: highly selective sensing of singlet oxygen in FDA-approved phototherapy

Yao Lu, Yutao Zhang, Xia Wu, Ruihua Pu, Chenxu Yan, Weimin Liu, Xiaogang Liu, Zhiqian Guo and Wei-Hong Zhu

Chem. Sci., 2024, 15, 12431
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Hydrogen-bond tuned conjugated architectures for nitric oxide sensing in single-benzene framework: Advances and mechanistic insights

Feng-Zao Chen, Cun-Bin Du, Yi-Chao Wang, Jie Zhu, Ge Cheng, Kai-Bin Li, De-Man Han and Xiao-Yu Wu

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Central Ring Puckering Enhances the Stokes Shift of Xanthene Dyes

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A ratiometric nitric oxide fluorescent probe with ICT modulation for spatiotemporal imaging in live cells and zebrafish

Bin Lin, Jiaxin Fan, Shuting Li and Yifeng Han

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Construction of a novel NIR-emissive rhodamine derivative for monitoring mitochondrial viscosity in ferroptosis

Chang Liu, Chuang Feng, Yan Liu, Yuanyuan Wu, Huirong Yao, Song He and Xianshun Zeng

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Near-infrared theranostics for brain diseases: Design, engineering, and emerging applications

Jiefei Wang, Yisheng Liu, Cai Qi, Zhengqun Luo, Jinfeng Wei, Gaoyang Wang, Muhammad Ismail, Yong Zhong and Bingyang Shi

Coordination Chemistry Reviews, 2025, 534, 216591
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Organic Fluorophores with Large Stokes Shift for Bioimaging and Biosensing

Hong Liu, Gangwei Jiang, Guoliang Ke, Tian‐Bing Ren and Lin Yuan

ChemPhotoChem, 2024, 8
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Rational Design of Organic NIR-II fluorophores for advanced Photothermal and photodynamic therapy

Miao Zou, Jinlong Jiao, Maofei Lv, Luhan Hou, Shiyu Zhou, Zhanglin Chen and Tianlu Mo

Coordination Chemistry Reviews, 2026, 556, 217643
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Orthogonal NIR/Ratiometric Probe for Simultaneous Imaging of NO and ATP in Acute Lung Injury: Elucidating Metabolic Dysregulation and Therapeutic Screening

Xinyue Li, Jinzhen Zheng, Ning Li, Panpan Sun, Zhiang Duan, Wenyuan Cheng, Wenting Guo and Baodui Wang

Anal. Chem., 2026, 98, 8605
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Current Status and Future Developments in NIR‐II‐emitting Organic Small Molecule Fluorophores for Bioimaging and Phototherapy

Jiashuo Ye, Dayang Wang, Huanchen Yao, Hailin Cong, Youqing Shen and Bing Yu

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NIR-II organic fluorophores integrated with blood–brain barrier-penetrating strategies for brain disease theranostics

Xiaobo Wang, Yuying Tan, Jierui Yan, Min Chen, Na Xie, Sha Wu, Fuhan Fan, Luming Qi, Shuangxi Gu, Kun Qian, Xianli Meng, Qihang Ding, Ya Hou, Zhen Cheng and Yang Li

Coordination Chemistry Reviews, 2026, 551, 217466
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Dynamic Visualization of Amyloid-β Plaques with a Novel NIR-II Fluorescence Reporter

Feifan Xiang, Hong Zhang, Dingheng Zhou, Yang Yu, Shanyong Chen, Qian Zhou, Yuanyuan Zhang, Min Wu, Kun Li and Xiaoqi Yu

Anal. Chem., 2026, 98, 5085
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High selective NIR-II fluorescent probe for sensing phosgene in plants

Shuairu Wang, Dongsheng Lian, Chuyang Sun, Minghao Xu, Mingming Zhu, Chenxu Yan and Zhiqian Guo

Chinese Chemical Letters, 2025, 111744
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Luminescent probes for detecting and bioimaging of nitric oxide and carbon monoxide

Guihai Gan, Tengfei Ma, Guoying Zhang, Kewu He and Jinming Hu

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Application of biomarker-derived fluorescent probes for the detection of Alzheimer's disease

Haitao Ding, Zhiqian Li, Kui Luo, Qiyong Gong and Xiaohe Tian

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Illuminating the brain: Advanced fluorescent probes for neurotransmitter-based biomarkers in neurological diseases

Ratish R. Nair, Byung Seok Cha, Jeong Jun Park, Yun Hak Kim, Hyo In Kim and Dokyoung Kim

Coordination Chemistry Reviews, 2026, 549, 217335
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Electron-donating substituents allow boosted fluorescence emission wavelengths of Dihydropyridopyrazine functionalized xanthene

Caidong Shuang, Chong Chang, Pingping Sun, Chaoyuan Zeng and Weijie Chi

Chemical Physics, 2025, 593, 112641
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Unraveling the potential of gasotransmitters as neurogenic and neuroprotective molecules: focus on Alzheimer’s and Parkinson’s diseases

Sónia Simão, Daniela F. Santos, Mariana Teixeira, Rafaela R. Agostinho, Joana Rodrigues, Marta Vitorino and Inês M. Araújo

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Advances in probe crossing the blood–brain barrier strategies and fluorescent imaging for brain dynamics

Shiyu Wang, Hongjun Song, Caixia Yin and Fangjun Huo

Coordination Chemistry Reviews, 2025, 543, 216940
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Mitochondria-targeted ultrafast fluorogenic probes for real-time capture of endogenous superoxide anion dynamics in live cells

Lan Wang, Xiaole Liu, Yihang Su, Songhao Pang, Yongna Lu, Feng Qiu, Xiao Huang, Xiamin Cheng, Qiong Wu and Su Jing

Sensors and Actuators B: Chemical, 2026, 458, 139795
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“Crossbreeding” NIR‐II flavchromene for PSMA‐positive prostate cancer detection and image‐guided surgery

Jialiang Huang, Yongkang Yao, Liao Zhang, Chenxu Yan and Zhiqian Guo

Smart Molecules, 2024, 2
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Imaging of Carbonic Anhydrase Level in Epilepsy with an Environment-Sensitive Fluorescent Probe

Fang Zhang, Fan Chen, Miao Zhong, Ruipeng Shen, Zhengjia Zhao, Haopai Wei, Baoxin Zhang and Jianguo Fang

Anal. Chem., 2023, 95, 14833
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Bright, Robust and Readily Accessible Fluorophore Family for NIR-II Bioimaging

Hui Bian, Dandan Ma, Xiaodong Zhang, Yangting Qiu, Xia Wu, Mingyan Jia, Xinfu Zhang, Xiaogang Liu, Youjun Yang, Xiaojun Peng, Juyoung Yoon and Yi Xiao

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A mitochondria-targeted fluorescent probe for revealing H2O2 elevation modulated by basal HClO in HeLa and A549 cells

Nan Yin, Yuting Wang, Guixin Qin, Mingxiu Wang, Jiali Tang, Xin Yao, Qingling Xu and Juyoung Yoon

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An activated fluorescent probe to monitor NO fluctuation in Parkinson's disease

Tao Liu, Xuwei Han, Xueyi Sun, Weijie Zhang, Ke Gao, Runan Min, Yuting Tian and Caixia Yin

Chinese Chemical Letters, 2025, 36, 110170
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Synthesis of NIR‐II Fluorophores by a C(sp2)−C(sp2/sp) Coupling Reaction Driven by Charge‐Transfer Interaction

Jie Li, Xin‐Xin Liu, Ling‐Ya Peng, Li‐Ya Niu, Wenguang Wang, Ganglong Cui and Qing‐Zheng Yang

Angewandte Chemie, 2025, 137
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Molecular Engineering of Sulfone-Xanthone Chromophore for Enhanced Fluorescence Navigation

Hong Zhang, Fei-Fan Xiang, Yan-Zhao Liu, Yu-Jin Chen, Ding-Heng Zhou, Yan-Hong Liu, Shan-Yong Chen, Xiao-Qi Yu and Kun Li

JACS Au, 2023, 3, 3462
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Synthesis of NIR‐II Fluorophores by a C(sp2)−C(sp2/sp) Coupling Reaction Driven by Charge‐Transfer Interaction

Jie Li, Xin‐Xin Liu, Ling‐Ya Peng, Li‐Ya Niu, Wenguang Wang, Ganglong Cui and Qing‐Zheng Yang

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Activable chimeric bioluminescent sensors via electrostatic protein engineering for field-deployable imaging of wound infection

Junbin Li, Min Dai, Tianxin Zhang, Xindi Sun, Du Lian, Mengyi Xiong, Yibo Zhou and Zhihe Qing

Chinese Chemical Letters, 2026, 112449
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Activatable small-molecule NIR fluorescent/photoacoustic probes for brain disease imaging

Jingwen Zou, Yujin Kim, Yubin Lee, Seokjin Hong, Kippeum Lee, Fan Zhang, Zhiqiang Mao and Jong Seung Kim

Coordination Chemistry Reviews, 2026, 547, 217149
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NIR-II fluorescence imaging for diagnostics and therapy of non-cancer diseases

Muhammad Sohail, Haroon Ahmad, Ishaq Ali Shah, Muhammad Umar Javed, Muhammad Sohaib Iqbal, Yibin Yan, Xuejin Wang, Han Wang, Adeel Afzal and Bing Guo

Coordination Chemistry Reviews, 2026, 557, 217751
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Chemical Approaches to Optimize the Properties of Organic Fluorophores for Imaging and Sensing

Gangwei Jiang, Han Liu, Hong Liu, Guoliang Ke, Tian‐Bing Ren, Bin Xiong, Xiao‐Bing Zhang and Lin Yuan

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Computational chemistry facilitates the development of second near-infrared xanthene-based dyes

Qinlin Yuan, Mingyu Wang, Mingyue Ma, Pingping Sun, Chaoyuan Zeng and Weijie Chi

J Mol Model, 2024, 30
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Frequency upconversion luminescence: New frontiers in bioapplications

Hui Yu, Yun Chai, Aliya Tiemuer, Yuxuan Han, Hai-Yan Wang and Yi Liu

Coordination Chemistry Reviews, 2023, 496, 215379
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Near-Infrared Organic Small-Molecule Fluorophores for Biological System and Organ-Level Imaging of Diseases: Recent Advances

Pachaiyappan Murugan, Fang Yang, Changlin Yu and Shi-Yong Liu

Anal. Chem., 2026, 98, 3413
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A novel mitochondrial-targeted fluorescent probe for ratiometric imaging of nitric oxide in cells and zebrafish

Bin Lin, Jiaxin Fan, Shuting Li and Yifeng Han

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2025, 329, 125636
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Ex Tenebris Lux: Illuminating Reactive Oxygen and Nitrogen Species with Small Molecule Probes

Maidileyvis C. Cabello, Gen Chen, Michael J. Melville, Rokia Osman, G. Dinesh Kumar, Dylan W. Domaille and Alexander R. Lippert

Chem. Rev., 2024, 124, 9225
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Activatable Molecular Probes With Clinical Promise for NIR‐II Fluorescent Imaging

Zikang Chen, Yongjie Zhou, Li Li, Wen Ma, Yuzhen Li and Zhen Yang

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Chemical Approaches to Optimize the Properties of Organic Fluorophores for Imaging and Sensing

Gangwei Jiang, Han Liu, Hong Liu, Guoliang Ke, Tian‐Bing Ren, Bin Xiong, Xiao‐Bing Zhang and Lin Yuan

Angew Chem Int Ed, 2024, 63
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Recent advances in the design and applications of near-infrared II responsive small molecule phototherapeutic agents

Dandan Ma, Hui Bian, Mingrui Gu, Lei Wang, Xiaoqiang Chen and Xiaojun Peng

Coordination Chemistry Reviews, 2024, 505, 215677
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Silicon Rhodamine-Based Fluorescence Lifetime Probe for Dynamics Mapping Lysosomal Oxidative Stress

Qingshuang Xu, Yiyan Zhang, Yuxun Tang, Senqiang Lv, Lianfeng Su, Pengfeng Mao, Pengqi Liu, Yutao Zhang, Chenxu Yan and Zhiqian Guo

Chemical & Biomedical Imaging, 2026, 4, 105
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Research progress on a near-infrared fluorescence probe composed of carbazole skeleton for biological imaging

Jianqiang Qian, Yaqin Gu, Zihao Wang, Mingshi Pan, Dingding Li and Jinfeng Ding

Journal of Molecular Structure, 2026, 1351, 144222
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Evaluation of a biomarker (NO) dynamics in inflammatory zebrafish and periodontitis saliva samples via a fast-response and sensitive fluorescent probe

Yibin Zhang, Shaocai Wang, Yu Sun, Hanbo Xu, Zihan Xu, Xin Liang, Jianguang Yang, Weiyi Song, Minghui Chen and Mingxi Fang

Bioorganic Chemistry, 2024, 143, 107014
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Optimization of CNT growth-upheaved nanofilm for highly sensitive fluorescent detection of Alzheimer’s disease

Yeongseok Jang, Jinyoung Won, Youngjeon Lee, Seul-Hyun Park and Jonghyun Oh

Sensors and Actuators B: Chemical, 2024, 415, 135991
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Lipid droplets and gallbladder targeted fluorescence probe for ratiometric NO imaging in gallstones disease models

Zhoupeng Zheng, Shengyi Gong, Qianhua Li, Shiya Zhang and Guoqiang Feng

Chinese Chemical Letters, 2025, 36, 110191
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