Zinc-based biomaterials for bone repair and regeneration: mechanism and applications

Xinyu Wen, Jian Wang, Xibo Pei and Xin Zhang

J. Mater. Chem. B, 2023, 11, 11405
DOI: 10.1039/D3TB01874A

pH-Responsive nanoplatform synergistic gas/photothermal therapy to eliminate biofilms in poly(l-lactic acid) scaffolds

Guowen Qian, Yuqian Mao, Huihui Zhao, Lemin Zhang, Long Xiong and Zhisheng Long

J. Mater. Chem. B, 2024, 12, 1379
DOI: 10.1039/D3TB02600K

Recent advances in carbon dots: synthesis and applications in bone tissue engineering

Ran Zhang, Yuxi Hou, Lingxiang Sun, Xiaoming Liu, Yifan Zhao, Qingmei Zhang, Yanjie Zhang, Lu Wang, Ran Li, Chunfang Wang, Xiuping Wu and Bing Li

Nanoscale, 2023, 15, 3106
DOI: 10.1039/D2NR05951G

Zn-assisted modification of the chemical structure of N-doped carbon dots and their enhanced quantum yield and photostability

Sohee Yun, Eun Soo Kang and Jin-sil Choi

Nanoscale Adv., 2022, 4, 2029
DOI: 10.1039/D2NA00013J

Novel multifunctional dexamethasone carbon dots synthesized using the one-pot green method for anti-inflammatory, osteogenesis, and osteoimmunomodulatory in bone regeneration

Chang Wan, Mengyue Hu, Xu Peng, Ningning Lei, Hongmei Ding, Yihao Luo and Xixun Yu

Biomater. Sci., 2022, 10, 6291
DOI: 10.1039/D2BM01153K

3D-plotted zinc silicate/β-tricalcium phosphate ceramic scaffolds enable fast osteogenesis by activating the p38 signaling pathway

Xinyuan Yuan, Teliang Lu, Fupo He, Tingting Wu, Xiaolan Wang and Jiandong Ye

J. Mater. Chem. B, 2022, 10, 9639
DOI: 10.1039/D2TB01868C

Carbon dots as a new class of multifunctional nanomaterial in mesenchymal stem cells: opportunities and challenges

Qian He, Zewen Wu and Liyun Zhang

J. Mater. Chem. B, 2023, 11, 3511
DOI: 10.1039/D2TB02790A

Metal-organic frameworks/polydopamine coating endows polyetheretherketone with disinfection and osteogenicity

Yong Chen, Qizhang Yang, Daichuan Ma, Liming Peng, Yurong Mao, Xiong Zhou, Yi Deng and Weizhong Yang

International Journal of Polymeric Materials and Polymeric Biomaterials, 2022, 71, 783
DOI: 10.1080/00914037.2021.1909585

Novel yellow solid-state fluorescent-emitting carbon dots with high quantum yield for white light-emitting diodes

Hai-Jiao Wang, Wan-Yi Hou, Yong-Wei Hao, Wen-Shuai Jiang, Hong-Li Chen and Qi-Qing Zhang

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2021, 250, 119340
DOI: 10.1016/j.saa.2020.119340

Review of Pharmacologically Active Carbon Dots as Versatile Nanotherapeutics

Huan Wang, Yuxi Fang, Yanjun Ji and Jinsong Ren

ACS Appl. Nano Mater., 2025, 8, 17356
DOI: 10.1021/acsanm.5c03216

The Role of Zinc in Bone Tissue Health and Regeneration—a Review

Magda Molenda and Joanna Kolmas

Biol Trace Elem Res, 2023, 201, 5640
DOI: 10.1007/s12011-023-03631-1

The Role of Trace Elements and Minerals in Osteoporosis: A Review of Epidemiological and Laboratory Findings

Anatoly V. Skalny, Michael Aschner, Ekaterina V. Silina, Victor A. Stupin, Oleg N. Zaitsev, Tatiana I. Sotnikova, Serafima Ia. Tazina, Feng Zhang, Xiong Guo and Alexey A. Tinkov

Biomolecules, 2023, 13, 1006
DOI: 10.3390/biom13061006

The impact of Zn-doped synthetic polymer materials on bone regeneration: a systematic review

Siyi Wang, Rong Li, Dandan Xia, Xiao Zhao, Yuan Zhu, Ranli Gu, Jungmin Yoon and Yunsong Liu

Stem Cell Res Ther, 2021, 12
DOI: 10.1186/s13287-021-02195-y

Emerging and Versatile Platforms of Metal‐Ion‐Doped Carbon Dots for Biosensing, Bioimaging, and Disease Therapy

Sihua Qian, Lin Li, Kerong Wu, Yuhui Wang, Gang Wei and Jianping Zheng

ChemMedChem, 2023, 18
DOI: 10.1002/cmdc.202200479

Nanocomposites of nitrogen/zinc-doped carbon dots@ hydrotalcite with highly fluorescent in solid-state for visualization of latent fingerprints

Da-Wu Li, Xing-Fu Zhang, Xiao-Tong Zhang, Xiao-Sen lv and Nan You

Optical Materials, 2023, 137, 113530
DOI: 10.1016/j.optmat.2023.113530

Carnosine, Zinc and Copper: A Menage a Trois in Bone and Cartilage Protection

Valeria Ciaffaglione and Enrico Rizzarelli

IJMS, 2023, 24, 16209
DOI: 10.3390/ijms242216209

Doped-carbon dots: Recent advances in their biosensing, bioimaging and therapy applications

Legha Ansari, Shahin Hallaj, Tooba Hallaj and Mohammad Amjadi

Colloids and Surfaces B: Biointerfaces, 2021, 203, 111743
DOI: 10.1016/j.colsurfb.2021.111743

Carbon Dots Based Photoinduced Reactions: Advances and Perspective

Yue Yu, Qingsen Zeng, Songyuan Tao, Chunlei Xia, Chongming Liu, Pengyuan Liu and Bai Yang

Advanced Science, 2023, 10
DOI: 10.1002/advs.202207621

Blocking Metallothionein-2 Expression by Copper-Doped Carbon Dots Induces Cellular Antioxidant System Collapse for Antitumor Therapy

Kexuan Liu, Xinchen Liu, Linlin Wen, Wenhao Zhai, Rongrong Ye, Boya Zhang, Wangni Xie, Xue Zhang, Wenbing Zhang, Haiqiu Li, Jiaqi Xu, Lei Huang, Huan Wang, Daowei Li and Hongchen Sun

Nano Lett., 2024, 24, 10699
DOI: 10.1021/acs.nanolett.4c03418

Nanoengineered Endocytic Biomaterials for Stem Cell Therapy

Yingxue Wang, Chunhui Sun, Zhaoying Liu, Shengmin Zhang, Ke Gao, Fan Yi, Wenjuan Zhou and Hong Liu

Adv Funct Materials, 2024, 34
DOI: 10.1002/adfm.202410714

The Antibiofilm Activity and Mechanism of Nanosilver- and Nanozinc-Incorporated Mesoporous Calcium-Silicate Nanoparticles

Diya Leng, Yan Li, Jie Zhu, Ruizhen Liang, Cuifeng Zhang, Yang Zhou, Mingming Li, Ying Wang, Di Rong, Daming Wu and Jin Li

IJN, 2020, Volume 15, 3921
DOI: 10.2147/IJN.S244686

Carbon Quantum Dots for Stem Cell Imaging and Deciding the Fate of Stem Cell Differentiation

Misba Majood, Piyush Garg, Radhika Chaurasia, Aakanksha Agarwal, Sujata Mohanty and Monalisa Mukherjee

ACS Omega, 2022, 7, 28685
DOI: 10.1021/acsomega.2c03285

Nano-ZnO-modified hydroxyapatite whiskers with enhanced osteoinductivity for bone defect repair

Penggong Wei, Ning Wang, Qiyue Zhang, Wanfeng Wang, Hui Sun, Zengqian Liu, Tingting Yan, Qiang Wang and Lihong Qiu

Regenerative Biomaterials, 2024, 11
DOI: 10.1093/rb/rbae051

Stem Cell Membrane‐Encapsulated Zeolitic Imidazolate Framework‐8: A Targeted Nano‐Platform for Osteogenic Differentiation

Na Ren, Na Liang, Mengwei Dong, Zhichao Feng, Ling Meng, Chunhui Sun, Aizhu Wang, Xin Yu, Wenhan Wang, Juan Xie, Chao Liu and Hong Liu

Small, 2022, 18
DOI: 10.1002/smll.202202485

Advances in Use of Nanomaterials for Musculoskeletal Regeneration

Josef Jampilek and Daniela Placha

Pharmaceutics, 2021, 13, 1994
DOI: 10.3390/pharmaceutics13121994

Zinc Doped Synthetic Polymer Composites for Bone Regeneration: A Promising Strategy to Repair Bone Defects

Long Chen, Chao Zhou, Qiong Xie, Linying Xia, Lu Liu, Wenwen Bao, Hongming Lin, Xiaochun Xiong, Hao Zhang, Zeping Zheng, Jiayi Zhao and Wenqing Liang

IJN, 2025, Volume 20, 8567
DOI: 10.2147/IJN.S512994

Biodegradable Zinc‐Based Alloys for Guided Bone Regeneration Membranes: Feasibility, Current Status, and Future Prospects

Kai Chen, Ping Li, Qiang Guan, Xuenan Gu, Li Zhao, Linjun Huang, Chenyang Huang, Yu Qin, Chunhao Yu, Ting Zhang, Hejia Li, Yongcan Huang and Yufeng Zheng

Advanced Science, 2025, 12
DOI: 10.1002/advs.202506513

Concentration-Dependent Cellular Uptake of Graphene Oxide Quantum Dots Promotes the Odontoblastic Differentiation of Dental Pulp Cells via the AMPK/mTOR Pathway

Ling Lin, Yexin Zheng, Chao Wang, Pei Li, Duoling Xu and Wei Zhao

ACS Omega, 2023, 8, 5393
DOI: 10.1021/acsomega.2c06508

Metal Ions Doped-Carbon Dots: Synthetic Approaches, Physicochemical Properties and Their Applications

Dinh Khoi Dang and Thanh Tung Pham

JTE, 2022, 54
DOI: 10.54644/jte.73.2022.1167

Metformin carbon nanodots promote odontoblastic differentiation of dental pulp stem cells by pathway of autophagy

Jinjin Lu, Rui Li, Shilei Ni, Yuandong Xie, Xinchen Liu, Kai Zhang and Yi Li

Front. Bioeng. Biotechnol., 2022, 10
DOI: 10.3389/fbioe.2022.1002291

Design of Carbon Dots for Bioimaging and Behavior Regulation of Stem Cells

Jing Li, Rongshuang Tan, Xueru Bian, Zhangjie Ge, Jiamin Li, Zhihui Li, Lingzi Liao, Ling Yang, Rui Zhang and Ping Zhou

Nanomedicine (Lond.), 2023, 18, 1109
DOI: 10.2217/nnm-2023-0005

Research status of biodegradable metals designed for oral and maxillofacial applications: A review

Dandan Xia, Fan Yang, Yufeng Zheng, Yunsong Liu and Yongsheng Zhou

Bioactive Materials, 2021, 6, 4186
DOI: 10.1016/j.bioactmat.2021.01.011

Rational design of zinc single-atom carbon dots as multifunctional nanozymes with antioxidant and osteogenic potential

Can Li, Guiming Niu, Fucheng Gao, Mingxia Lu, Sen Wang, Zhichao Deng, Pengyu Gong, Ying Ruan, Suqin Jin and Yanyan Jiang

Colloids and Surfaces B: Biointerfaces, 2026, 263, 115607
DOI: 10.1016/j.colsurfb.2026.115607

Applications of carbon dots and its modified carbon dots in bone defect repair

Longchuan Zhu, Weijian Kong, Jijun Ma, Renfeng Zhang, Cheng Qin, Hao Liu and Su Pan

J Biol Eng, 2022, 16
DOI: 10.1186/s13036-022-00311-x

Multilayered polyvinyl alcohol-based nanofibrous membranes functionalized for osteogenic induction of mesenchymal stem cells

Hayrullah Çetinkaya, Özlem Altundag-Erdogan, Betül Çelebi-Saltik and Mustafa Özgür Öteyaka

J. Mater. Res., 2025, 40, 3267
DOI: 10.1557/s43578-025-01688-3

Comparison of osteogenic capability between porous Zn and porous Ti6Al4V scaffolds: An in vivo study

Pu Ying, Fujun Chen, Linghui Meng, Jie Cui, Jingwei Lu, Jing Jin, Chunmei Xie, Jianhao Huang, Qiang Lu, Xiaohong Wang, Huixin Liang and Wei Xu

Journal of Materials Research and Technology, 2024, 29, 5330
DOI: 10.1016/j.jmrt.2024.03.031

WITHDRAWN: Carbon Dots as Promising Carbon Nanomaterials for Diagnostics, Therapeutics, and Regenerative Orofacial Applications

Gamal Abdel Nasser Atia, Sara Z. Mohamed, Noha Taymour, Magdalen M. Soliman, Hamdy Abdel Halim, Hany K. Shalaby, Mohamed M. Ghobashy, Paritosh Barai, Md Azizul Haque and Hasi Rani Barai

Journal of Drug Delivery Science and Technology, 2025, 106808
DOI: 10.1016/j.jddst.2025.106808

Metal-doped carbon dots for biomedical applications: From design to implementation

Jin Qi, Pengfei Zhang, Tong Zhang, Ran Zhang, Qingmei Zhang, Jue Wang, Mingrui Zong, Yajuan Gong, Xiaoming Liu, Xiuping Wu and Bing Li

Heliyon, 2024, 10, e32133
DOI: 10.1016/j.heliyon.2024.e32133

Metformin Carbon Dots for Promoting Periodontal Bone Regeneration via Activation of ERK/AMPK Pathway

Chunxia Ren, Xinqing Hao, Lu Wang, Yue Hu, Lin Meng, Shize Zheng, Feilong Ren, Wenhuan Bu, Huan Wang, Daowei Li, Kai Zhang and Hongchen Sun

Adv Healthcare Materials, 2021, 10
DOI: 10.1002/adhm.202100196

Tailoring Scaffolds for Orthopedic Application With Anti-Microbial Properties: Current Scenario and Future Prospects

A. Preethi and Jayesh R. Bellare

Front. Mater., 2021, 7
DOI: 10.3389/fmats.2020.594686

Carbon dots for drug delivery: Insights into their potential in nanopharmacology

Daniela Iannazzo, Consuelo Celesti, Lucia Cardo, Maurizio Prato and Alessandra Bitto

Pharmacological Reviews, 2026, 78, 100107
DOI: 10.1016/j.pharmr.2025.100107

Advances and Prospects in Materials for Craniofacial Bone Reconstruction

Li Gu, Rui Huang, Ni Ni, Ping Gu and Xianqun Fan

ACS Biomater. Sci. Eng., 2023, 9, 4462
DOI: 10.1021/acsbiomaterials.3c00399

RETRACTED ARTICLE: Near Infrared Light-Actuated PEG Wrapping Carbon Nanodots Loaded Cisplatin for Targeted Therapy of Lung Cancer Therapy

Chan Lian, Jiangnan Zhang, Bingqing Ruan, Kangtai Ying, Wei Lin and Zhe Chen

J Clust Sci, 2021, 32, 125
DOI: 10.1007/s10876-020-01769-9

Zinc-Doped Carbon Dots as Effective Blue-Light-Activated Antibacterial Agent

Dongning Liu, Mingxi Yang, Xinchan Liu and Weixian Yu

NANO, 2021, 16, 2150031
DOI: 10.1142/S1793292021500314

The Role of Zinc in Bone Mesenchymal Stem Cell Differentiation

Huiyun Li, Muzhe Li, Xun Ran, Juncheng Cui, Fu Wei, Guoliang Yi, Wei Chen, Xuling Luo and Zhiwei Chen

Cellular Reprogramming, 2022, 24, 80
DOI: 10.1089/cell.2021.0137

Bone Immune Microenvironment-Modulating Naringin Carbon Dot Complex Hydrogel with ROS-Scavenging and Antibacterial Properties for Enhanced Bone Repair

Xu Wei, Xu Peng, Yihao Luo, Shaoxiong Feng, Yiqing Deng, Xinyun Pu and Xixun Yu

ACS Appl. Mater. Interfaces, 2025, 17, 30759
DOI: 10.1021/acsami.5c07627

Polylysine-derived carbon quantum dots modulate T lymphocyte responses for periodontitis treatment

Xuyang Deng, Bingcheng Yi, Fangze Guo, Danyang Wang, Siyuan Wu, Yongzhi Xu, Hailin Huang, Junqiang Fang, Shichao Jiang, Changqing Yuan and Qihui Zhou

Materials & Design, 2024, 241, 112975
DOI: 10.1016/j.matdes.2024.112975

Effects of Zinc, Magnesium, and Iron Ions on Bone Tissue Engineering

Zhixuan Chen, Wei Zhang, Mingyue Wang, Ludvig J. Backman and Jialin Chen

ACS Biomater. Sci. Eng., 2022, 8, 2321
DOI: 10.1021/acsbiomaterials.2c00368

Meta-analysis of the Relationship Between Zinc and Copper in Patients with Osteoarthritis

Haowei Zhou, Yuchen Zhang, Tian Tian, Bingqian Wang and Yalei Pan

Biol Trace Elem Res, 2025, 203, 635
DOI: 10.1007/s12011-024-04197-2

Research Progress on the Application of Carbon Dot Materials in the Field of Oral Medicine

凯王

MS, 2024, 14, 1084
DOI: 10.12677/ms.2024.147122

Biodegradable magnesium-based alloy skull repairment (MASR) for skull bone defect: In vitro and in vivo evaluation

Anke Zhang, Xiaoyu Wang, Zeyu Zhang, Xiyue Zhang, Junjie Wang, Yibo Liu, Yan Chen, Jiarui Chen, Ting Chen, Yongjie Wang, Jun Yu, Jia She, Wenhui Wang, Xiaonong Zhang and Jianmin Zhang

Chemical Engineering Journal, 2024, 493, 152761
DOI: 10.1016/j.cej.2024.152761

Nanomedicine for Cranial Repair: Insights From Recent Advance in Nanomaterial‐Based Cranioplasty

Tingting Zhang, Tong Sun, Xiaoshuang Dai, Dingkun Zhang and Junwen Guan

MedComm – Biomaterials and Applications, 2025, 4
DOI: 10.1002/mba2.70026

A comprehensive review on nanocomposite biomaterials based on gelatin for bone tissue engineering

Elaheh Salehi Abar, Somayeh Vandghanooni, Ali Torab, Mehdi Jaymand and Morteza Eskandani

International Journal of Biological Macromolecules, 2024, 254, 127556
DOI: 10.1016/j.ijbiomac.2023.127556

Bioactive carbon dots for tissue engineering applications

Qi Zong, Haolin Chen, Yi Zhao, Jinming Wang and Jun Wu

Smart Materials in Medicine, 2024, 5, 1
DOI: 10.1016/j.smaim.2023.06.006

Dexamethasone and Doxycycline Doped Nanoparticles Increase the Differentiation Potential of Human Bone Marrow Stem Cells

Manuel Toledano-Osorio, Sergio López-García, Raquel Osorio, Manuel Toledano, David García-Bernal, Sonia Sánchez-Bautista and Francisco Javier Rodríguez-Lozano

Pharmaceutics, 2022, 14, 1865
DOI: 10.3390/pharmaceutics14091865

Carbon dots derived from folic acid attenuates osteoarthritis by protecting chondrocytes through NF-κB/MAPK pathway and reprogramming macrophages

Yu Jin, Qing Zhang, Xing Qin, Zhen Liu, Zhenxia Li, Xiaoxia Zhong, Lunguo Xia, Jie He and Bing Fang

J Nanobiotechnol, 2022, 20
DOI: 10.1186/s12951-022-01681-6

Carbon Quantum Dots as Multi‐Purpose Nanomaterial in Stem Cell Therapy

Kobra Bahrampour Juybari, Komal Rizwan, Sanaz Faramarz, Asie Sadeghi, Arian Amirkhosravi, Mohammad Hadi Nematollahi and Mehrnaz Mehrabani

Chemistry & Biodiversity, 2023, 20
DOI: 10.1002/cbdv.202200721

The applications of carbon dots in oral health: A scoping review

Cuicui Fu, Henk S. Brand and Floris J. Bikker

Oral Diseases, 2024, 30, 1861
DOI: 10.1111/odi.14702

Metal ions-doped carbon dots: Synthesis, properties, and applications

Xiangcao Li, Yanzhao Fu, Shaojing Zhao, JiaFu Xiao, Minhuan Lan, Benhua Wang, Kui Zhang, Xiangzhi Song and Lintao Zeng

Chemical Engineering Journal, 2022, 430, 133101
DOI: 10.1016/j.cej.2021.133101

SiO2-Coated ZnO for Photothermal and Photodynamic Antibacterial Applications in Bone Repair

Yanxia Zhang, Nazakaiti Imamaimaiti, Xiaohui Tang, Jua Kim, Tao Jiang, Huiting Fu, Haobo Pan and Yingbo Wang

ACS Appl. Bio Mater., 2025, 8, 4766
DOI: 10.1021/acsabm.5c00147