Rhodamine-modified fluorescent half-sandwich iridium and ruthenium complexes: potential application as bioimaging and anticancer agents

Wenli Ma, Lihua Guo, Zhenzhen Tian, Shumiao Zhang, Xiangdong He, JuanJuan Li, Yuliang Yang and Zhe Liu

Dalton Trans., 2019, 48, 4788
DOI: 10.1039/C9DT00999J

Cyclometalated iridium(iii) complexes induce mitochondria-derived paraptotic cell death and inhibit tumor growthin vivo

Liang He, Kang-Nan Wang, Yue Zheng, Jian-Jun Cao, Ming-Fang Zhang, Cai-Ping Tan, Liang-Nian Ji and Zong-Wan Mao

Dalton Trans., 2018, 47, 6942
DOI: 10.1039/C8DT00783G

Luminescent iridium(iii) complexes as COX-2-specific imaging agents in cancer cells

Chenfu Liu, Chao Yang, Lihua Lu, Wanhe Wang, Weihong Tan, Chung-Hang Leung and Dik-Lung Ma

Chem. Commun., 2017, 53, 2822
DOI: 10.1039/C6CC08109F

Bromodomain and BET family proteins as epigenetic targets in cancer therapy: their degradation, present drugs, and possible PROTACs

Mohd. Muddassir, Kunjal Soni, Chetan B. Sangani, Abdullah Alarifi, Mohd. Afzal, Naaser A. Y. Abduh, Yongtao Duan and Poonam Bhadja

RSC Adv., 2021, 11, 612
DOI: 10.1039/D0RA07971E

Synthesis, characterization and biological evaluation of labile intercalative ruthenium(ii) complexes for anticancer drug screening

Huaiyi Huang, Pingyu Zhang, Yu Chen, Kangqiang Qiu, Chengzhi Jin, Liangnian Ji and Hui Chao

Dalton Trans., 2016, 45, 13135
DOI: 10.1039/C6DT01270A

Targeting Brd4 for cancer therapy: inhibitors and degraders

Yingchao Duan, Yuanyuan Guan, Wenping Qin, Xiaoyu Zhai, Bin Yu and Hongmin Liu

Med. Chem. Commun., 2018, 9, 1779
DOI: 10.1039/C8MD00198G

Inhibition of TLR1/2 dimerization by enantiomers of metal complexes

Li-Juan Liu, Wanhe Wang, Zhangfeng Zhong, Sheng Lin, Lihua Lu, Yi-Tao Wang, Dik-Lung Ma and Chung-Hang Leung

Chem. Commun., 2016, 52, 12278
DOI: 10.1039/C6CC06155A

Enhanced cancer therapy by the marriage of metabolic alteration and mitochondrial-targeted photodynamic therapy using cyclometalated Ir(iii) complexes

Jiangping Liu, Chengzhi Jin, Bo Yuan, Yu Chen, Xingguo Liu, Liangnian Ji and Hui Chao

Chem. Commun., 2017, 53, 9878
DOI: 10.1039/C7CC05518H

Discovery of a VHL and HIF1α interaction inhibitor with in vivo angiogenic activity via structure-based virtual screening

Chao Yang, Wanhe Wang, Linmin Chen, Jiaxin Liang, Sheng Lin, Ming-Yuen Lee, Dik-Lung Ma and Chung-Hang Leung

Chem. Commun., 2016, 52, 12837
DOI: 10.1039/C6CC04938A

Diiridium(iii) complexes: luminescent probes and sensors for G-quadruplex DNA and endoplasmic reticulum imaging

Tikum Florence Anjong, Gyoungmi Kim, Ha Yoon Jang, Juyoung Yoon and Jinheung Kim

New J. Chem., 2017, 41, 377
DOI: 10.1039/C6NJ02890J

Highly potent half-sandwich iridium and ruthenium complexes as lysosome-targeted imaging and anticancer agents

JuanJuan Li, Zhenzhen Tian, Zhishan Xu, Shumiao Zhang, Yaqian Feng, Lingdong Zhang and Zhe Liu

Dalton Trans., 2018, 47, 15772
DOI: 10.1039/C8DT02963F

Highly potent extranuclear-targeted luminescent iridium(iii) antitumor agents containing benzimidazole-based ligands with a handle for functionalization

Jyoti Yellol, Sergio A. Pérez, Gorakh Yellol, Juraj Zajac, Antonio Donaire, Gloria Vigueras, Vojtech Novohradsky, Christoph Janiak, Viktor Brabec and José Ruiz

Chem. Commun., 2016, 52, 14165
DOI: 10.1039/C6CC07909A

Novel cyclometalated iridium(iii) phosphine-imine (P^N) complexes: highly efficient anticancer and anti-lung metastasis agents in vivo

Zhishan Xu, Yuliang Yang, Xianglei Jia, Lihua Guo, Xingxing Ge, Genshen Zhong, Shujiao Chen and Zhe Liu

Inorg. Chem. Front., 2020, 7, 1273
DOI: 10.1039/C9QI01492F

Inhibition of the Ras/Raf interaction and repression of renal cancer xenografts in vivo by an enantiomeric iridium(iii) metal-based compound

Li-Juan Liu, Wanhe Wang, Shi-Ying Huang, Yanjun Hong, Guodong Li, Sheng Lin, Jinglin Tian, Zongwei Cai, Hui-Min David Wang, Dik-Lung Ma and Chung-Hang Leung

Chem. Sci., 2017, 8, 4756
DOI: 10.1039/C7SC00311K

Anthraquinone-bridged diruthenium(ii) complexes inhibit migration and invasion of human hepatocarcinoma MHCC97-H cells

Jin-Quan Wang, Jun-Feng Kou, Zi-Zhuo Zhao, Kang-Qiang Qiu and Hui Chao

Inorg. Chem. Front., 2017, 4, 1003
DOI: 10.1039/C7QI00149E

Ni(ii) complex with bishydrazone ligand: synthesis, characterization, DNA binding studies and pro-apoptotic and pro-differentiation induction in human cancerous cell lines

Nenad R. Filipović, Snežana Bjelogrlić, Tamara R. Todorović, Vladimir A. Blagojević, Christian D. Muller, Aleksandar Marinković, Miroslava Vujčić, Barbara Janović, Aleksandar S. Malešević, Nebojša Begović, Milan Senćanski and Dragica M. Minić

RSC Adv., 2016, 6, 108726
DOI: 10.1039/C6RA24604D

Pharmacophore based virtual screening for identification of marine bioactive compounds as inhibitors against macrophage infectivity potentiator (Mip) protein of Chlamydia trachomatis

Vijayan Ramachandran, Elavarasi Padmanaban, Kalaiarasan Ponnusamy, Subbarao Naidu and Manoharan Natesan

RSC Adv., 2016, 6, 18946
DOI: 10.1039/C5RA24999F

A graphitic hollow carbon nitride nanosphere as a novel photochemical internalization agent for targeted and stimuli-responsive cancer therapy

Chaoqun Liu, Zhaowei Chen, Zhenzhen Wang, Wei Li, Enguo Ju, Zhengqing Yan, Zhen Liu, Jinsong Ren and Xiaogang Qu

Nanoscale, 2016, 8, 12570
DOI: 10.1039/C5NR07719B

Antimicrobial activity of organometallic isonicotinyl and pyrazinyl ferrocenyl-derived complexes

Tameryn Stringer, Ronnett Seldon, Nicole Liu, Digby F. Warner, Christina Tam, Luisa W. Cheng, Kirkwood M. Land, Peter J. Smith, Kelly Chibale and Gregory S. Smith

Dalton Trans., 2017, 46, 9875
DOI: 10.1039/C7DT01952A

In vitro studies on the selective cytotoxic effect of luminescent Ru(ii)-p-cymene complexes of imidazo-pyridine and imidazo quinoline ligands

Pravinkumar Selvam, Sourav De, Priyankar Paira, S. K. Ashok Kumar, Selva Kumar R, Anbalagan Moorthy, Arjita Ghosh, Yung-Chih Kuo, Subhasis Banerjee and Shantha Kumar Jenifer

Dalton Trans., 2022, 51, 17263
DOI: 10.1039/D2DT02237K

Metal complexes as “protein surface mimetics”

Sarah H. Hewitt and Andrew J. Wilson

Chem. Commun., 2016, 52, 9745
DOI: 10.1039/C6CC03457H

A NIR phosphorescent osmium(ii) complex as a lysosome tracking reagent and photodynamic therapeutic agent

Pingyu Zhang, Yi Wang, Kangqiang Qiu, Zhiqian Zhao, Rentao Hu, Chuanxin He, Qianling Zhang and Hui Chao

Chem. Commun., 2017, 53, 12341
DOI: 10.1039/C7CC07776A

Half-sandwich iridium N-heterocyclic carbene anticancer complexes

Chuanlan Wang, Jinfeng Liu, Zhenzhen Tian, Meng Tian, Laijin Tian, Wenqian Zhao and Zhe Liu

Dalton Trans., 2017, 46, 6870
DOI: 10.1039/C7DT00575J

Identification of a rhodium(iii) complex as a Wee1 inhibitor againstTP53-mutated triple-negative breast cancer cells

Guan-Jun Yang, Hai-Jing Zhong, Chung-Nga Ko, Suk-Yu Wong, Kasipandi Vellaisamy, Min Ye, Dik-Lung Ma and Chung-Hang Leung

Chem. Commun., 2018, 54, 2463
DOI: 10.1039/C7CC09384E

A novel iridium(iii) complex for sensitive HSA phosphorescence staining in proteome research

Yi Wang, Huaiyi Huang, Ge Chen, Haijie Chen, Tingting Xu, Qian Tang, Hailiang Zhu, Qianling Zhang and Pingyu Zhang

Chem. Commun., 2018, 54, 3282
DOI: 10.1039/C8CC01597J

Influence of substituents on DNA and protein binding of cyclometalated Ir(iii) complexes and anticancer activity

Sujay Mukhopadhyay, Roop Shikha Singh, Rajendra Prasad Paitandi, Gunjan Sharma, Biplob Koch and Daya Shankar Pandey

Dalton Trans., 2017, 46, 8572
DOI: 10.1039/C7DT01015J

A reaction-based luminescent switch-on sensor for the detection of OH− ions in simulated wastewater

Chun Wu, Kasipandi Vellaisamy, Guanjun Yang, Zhen-Zhen Dong, Chung-Hang Leung, Jin-Biao Liu and Dik-Lung Ma

Dalton Trans., 2017, 46, 6677
DOI: 10.1039/C7DT00633K

An Iridium(III) Complex Inhibits JMJD2 Activities and Acts as a Potential Epigenetic Modulator

Li-Juan Liu, Lihua Lu, Hai-Jing Zhong, Bingyong He, Daniel W. J. Kwong, Dik-Lung Ma and Chung-Hang Leung

J. Med. Chem., 2015, 58, 6697
DOI: 10.1021/acs.jmedchem.5b00375

Astaxanthin reduces MMP expressions, suppresses cancer cell migrations, and triggers apoptotic caspases of in vitro and in vivo models in melanoma

Yen-Ting Chen, Chien-Jen Kao, Hsin-Yi Huang, Shi-Ying Huang, Chung-Yi Chen, Yun-Sheng Lin, Zhi-Hong Wen and Hui-Min David Wang

Journal of Functional Foods, 2017, 31, 20
DOI: 10.1016/j.jff.2017.01.005

Epigenetic modulation by inorganic metal complexes

Chung-Hang Leung, Li-Juan Liu, Ka-Ho Leung and Dik-Lung Ma

Coordination Chemistry Reviews, 2016, 319, 25
DOI: 10.1016/j.ccr.2016.03.014

Highly selective Electrochemiluminescent probe to histidine

Yuyang Zhou, Kai Xie, Lingyan Kong, Feng Chen and Dongyu Sun

Journal of Electroanalytical Chemistry, 2017, 799, 122
DOI: 10.1016/j.jelechem.2017.05.054

Targeting B-Raf inhibitor resistant melanoma with novel cell penetrating peptide disrupters of PDE8A – C-Raf

Connor M. Blair, Nicola M. Walsh, Bruce H. Littman, Frank W. Marcoux and George S. Baillie

BMC Cancer, 2019, 19
DOI: 10.1186/s12885-019-5489-4

RETRACTED: A 7-methoxybicoumarin derivative selectively inhibits BRD4 BD2 for anti-melanoma therapy

Guan-Jun Yang, Wanhe Wang, Pui-Man Lei, Chung-Hang Leung and Dik-Lung Ma

International Journal of Biological Macromolecules, 2020, 164, 3204
DOI: 10.1016/j.ijbiomac.2020.08.194

Targeting Bromodomain and Extraterminal Proteins for Drug Discovery: From Current Progress to Technological Development

Pan Tang, Jifa Zhang, Jie Liu, Cheng-Ming Chiang and Liang Ouyang

J. Med. Chem., 2021, 64, 2419
DOI: 10.1021/acs.jmedchem.0c01487

Synthesis, Structural and Biological Studies of Some Half‐Sandwich d6‐Metal Complexes with Pyrimidine‐Based Ligands

Basava Punna Rao Aradhyula, Mahesh Kalidasan, Krishnakant Gangele, Debojit K. Deb, Samanta L. Shepherd, Roger M. Phillips, Krishna Mohan Poluri and Mohan Rao Kollipara

ChemistrySelect, 2017, 2, 2065
DOI: 10.1002/slct.201601926

Novel approaches to targeting BRD4

Olesya A. Kharenko and Henrik C. Hansen

Drug Discovery Today: Technologies, 2017, 24, 19
DOI: 10.1016/j.ddtec.2017.10.003

Structure-Based Discovery of a Selective KDM5A Inhibitor that Exhibits Anti-Cancer Activity via Inducing Cell Cycle Arrest and Senescence in Breast Cancer Cell Lines

Guan-Jun Yang, Chung-Nga Ko, Hai-Jing Zhong, Chung-Hang Leung and Dik-Lung Ma

Cancers, 2019, 11, 92
DOI: 10.3390/cancers11010092

Recent advances of iridium(III) metallophosphors for health-related applications

Po-Yu Ho, Cheuk-Lam Ho and Wai-Yeung Wong

Coordination Chemistry Reviews, 2020, 413, 213267
DOI: 10.1016/j.ccr.2020.213267

Mitochondria-targeted cyclometalated iridium-β-carboline complexes as potent non-small cell lung cancer therapeutic agents

Jincan Chen, Xinhua Guo, Dunhui Li, Hong Tang, Jie Gao, Wenzhu Yu, Xufeng Zhu, Zirong Sun, Zunnan Huang and Lanmei Chen

Metallomics, 2023, 15
DOI: 10.1093/mtomcs/mfad035

Current landscape of BRD4 inhibitors: Selective targeting and protein degradation for enhanced efficacy

Linlin Deng, Erkang Tian, Ting Ma, Shaojie Liang, Sijia Hu, Linwei Li and Juan Li

Results in Chemistry, 2025, 18, 102670
DOI: 10.1016/j.rechem.2025.102670

The Bond Order of C2 from a Strictly N‐Representable Natural Orbital Energy Functional Perspective

Mario Piris, Xabier Lopez and Jesus M. Ugalde

Chemistry A European J, 2016, 22, 4109
DOI: 10.1002/chem.201504491

Evaluation of Perylene Bisimide‐Based RuII and IrIII Complexes as Photosensitizers for Photodynamic Therapy

Cristina Mari, Huaiyi Huang, Riccardo Rubbiani, Marcus Schulze, Frank Würthner, Hui Chao and Gilles Gasser

Eur J Inorg Chem, 2017, 2017, 1745
DOI: 10.1002/ejic.201600516

A Ruthenium(II) Complex Inhibits BRD4 for Synergistic Seno‐ and Chemo‐Immunotherapy in Cisplatin‐Resistant Tumor Cells

Jinrong Yang, Fa Wang, Shuqi Huang, Tao Feng, Kai Xiong, Yu Chen and Hui Chao

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202505689

Approaches towards understanding the mechanism-of-action of metallodrugs

Xiaolin Xiong, Liu-Yi Liu, Zong-Wan Mao and Taotao Zou

Coordination Chemistry Reviews, 2022, 453, 214311
DOI: 10.1016/j.ccr.2021.214311

Development of Natural Product-Conjugated Metal Complexes as Cancer Therapies

Dik-Lung Ma, Chun Wu, Sha-Sha Cheng, Fu-Wa Lee, Quan-Bin Han and Chung-Hang Leung

IJMS, 2019, 20, 341
DOI: 10.3390/ijms20020341

Unexpected transformation of aromatic dioximes to monoximes in cyclometallated Ir(III) complexes: Structural and cytotoxic insights

Madhusmita Jadab, Suvasmita Behera, Atanu Sahoo, Manas Kumar Santra, Swagatika Mallik, Jagadish Kumar and Satyanarayan Pal

Journal of Molecular Structure, 2026, 1360, 145540
DOI: 10.1016/j.molstruc.2026.145540

Thirty Years of the Drug Candidate NAMI‐A and the Myths in the Field of Ruthenium Anticancer Compounds: A Personal Perspective

Enzo Alessio

Eur J Inorg Chem, 2017, 2017, 1549
DOI: 10.1002/ejic.201600986

Revisiting metallodrugs for the treatment of skin cancers

Carlos M. Manzano, Douglas H. Nakahata and Raphael E.F. de Paiva

Coordination Chemistry Reviews, 2022, 462, 214506
DOI: 10.1016/j.ccr.2022.214506

Homocysteine-targeting compounds as a new treatment strategy for diabetic wounds via inhibition of the histone methyltransferase SET7/9

Guodong Li, Dan Li, Chun Wu, Shengnan Li, Feng Chen, Peng Li, Chung-Nga Ko, Wanhe Wang, Simon Ming-Yuen Lee, Ligen Lin, Dik-Lung Ma and Chung-Hang Leung

Exp Mol Med, 2022, 54, 988
DOI: 10.1038/s12276-022-00804-1

Cytotoxicity of Pyrazine-Based Cyclometalated (C^Npz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties

Benoît Bertrand, Julio Fernandez-Cestau, Jesus Angulo, Marco M. D. Cominetti, Zoë A. E. Waller, Mark Searcey, Maria A. O’Connell and Manfred Bochmann

Inorg. Chem., 2017, 56, 5728
DOI: 10.1021/acs.inorgchem.7b00339

Purified Astaxanthin from Haematococcus pluvialis Promotes Tissue Regeneration by Reducing Oxidative Stress and the Secretion of Collagen In Vitro and In Vivo

Hsin-Yu Chou, Dik-Lung Ma, Chung-Hang Leung, Chien-Chih Chiu, Tzyh-Chyuan Hour and Hui-Min David Wang

Oxidative Medicine and Cellular Longevity, 2020, 2020, 1
DOI: 10.1155/2020/4946902

Ester-Modified Cyclometalated Iridium(III) Complexes as Mitochondria-Targeting Anticancer Agents

Fang-Xin Wang, Mu-He Chen, Xiao-Ying Hu, Rui-Rong Ye, Cai-Ping Tan, Liang-Nian Ji and Zong-Wan Mao

Sci Rep, 2016, 6
DOI: 10.1038/srep38954

Recent development of transition metal complexes with in vivo antitumor activity

Jia-Xin Liang, Hai-Jing Zhong, Guanjun Yang, Kasipandi Vellaisamy, Dik-Lung Ma and Chung-Hang Leung

Journal of Inorganic Biochemistry, 2017, 177, 276
DOI: 10.1016/j.jinorgbio.2017.06.002

Organoruthenium Complexes with C^N Ligands are Highly Potent Cytotoxic Agents that Act by a New Mechanism of Action

Vojtech Novohradsky, Jyoti Yellol, Olga Stuchlikova, María Dolores Santana, Hana Kostrhunova, Gorakh Yellol, Jana Kasparkova, Delia Bautista, José Ruiz and Viktor Brabec

Chemistry A European J, 2017, 23, 15294
DOI: 10.1002/chem.201703581

Virtual Screening of Antitumor Inhibitors Targeting BRD4 Based on Machine Learning Methods

Keliang Wu, Chenghua Zhang, Bing He, Huanxin Li, Shan Tang, Tao Han and Bingke Li

ChemistrySelect, 2022, 7
DOI: 10.1002/slct.202104054

Highly efficient pure red organic light-emitting devices based on tris(1-phenyl-isoquinoline) iridium(III) with another wide gap iridium(III) complex as sensitizer

Yunlong Jiang, Liang Zhou, Rongzhen Cui, Yanan Li, Xuesen Zhao and Hongjie Zhang

Dyes and Pigments, 2016, 128, 26
DOI: 10.1016/j.dyepig.2016.01.011

A long-lived ferrocene-conjugated iridium(III) complex for sensitive turn-on luminescence detection of traces of DMSO in water and human serum

Chung-Nga Ko, Chun Wu, Guodong Li, Chung-Hang Leung, Jin-Biao Liu and Dik-Lung Ma

Analytica Chimica Acta, 2017, 984, 193
DOI: 10.1016/j.aca.2017.06.042

Review of Bioactive Secondary Metabolites from Marine Bryozoans in the Progress of New Drugs Discovery

Xiang Rong Tian, Hai Feng Tang, Xiao Lin Tian, Jia Jun Hu, Li Li Huang and Kirk R Gustafson

Future Med. Chem., 2018, 10, 1497
DOI: 10.4155/fmc-2018-0012

“Half-sandwich” Schiff-base Ir(III) complexes as anticancer agents

Ze-dong Mou, Ning Deng, Feng Zhang, Jiaying Zhang, Juan Cen and Xia Zhang

European Journal of Medicinal Chemistry, 2017, 138, 72
DOI: 10.1016/j.ejmech.2017.06.027

Identification of an in vivo orally active dual-binding protein-protein interaction inhibitor targeting TNFα through combined in silico/in vitro/in vivo screening

Hadley Mouhsine, Hélène Guillemain, Gabriel Moreau, Najla Fourati, Chouki Zerrouki, Bruno Baron, Lucille Desallais, Patrick Gizzi, Nesrine Ben Nasr, Julie Perrier, Rojo Ratsimandresy, Jean-Louis Spadoni, Hervé Do, Patrick England, Matthieu Montes and Jean-François Zagury

Sci Rep, 2017, 7
DOI: 10.1038/s41598-017-03427-z

Peroxiredoxin Depletion and Oxidative Stress by Cyclometalated Ir(III)-Isatin Complexes Renders Ferroptosis and Autophagic Cell Death in Triple-Negative Breast Cancer

Sujato Mukherjee, Shilpendu Ghosh, Renuga Devi M, Souryadip Roy, Shantanu Saha Roy, Moulinath Acharya, Bokara Kiran Kumar and Arindam Mukherjee

J. Med. Chem., 2025, 68, 21201
DOI: 10.1021/acs.jmedchem.5c01150

Discovery of β-carboline copper(II) complexes as Mcl-1 inhibitor and in vitro and in vivo activity in cancer models

Xing Lu, Yan-Cheng Liu, Chris Orvig, Hong Liang and Zhen-Feng Chen

European Journal of Medicinal Chemistry, 2019, 181, 111567
DOI: 10.1016/j.ejmech.2019.111567

Labelling proteins and peptides with phosphorescent d6 transition metal complexes

Timothy U. Connell and Paul S. Donnelly

Coordination Chemistry Reviews, 2018, 375, 267
DOI: 10.1016/j.ccr.2017.12.001

Photodynamic therapeutic potential and challenges of platinum group metal complexes in cancer treatment

Lazar Milović, Milica Međedović Stefanović, Emilija Milović, Nenad Janković and Ana Rilak Simović

Journal of Coordination Chemistry, 2026, 79, 250
DOI: 10.1080/00958972.2025.2603928

Theranostic Lysosomal Targeting Anticancer and Antimetastatic Agents: Half-Sandwich Iridium(III) Rhodamine Complexes

Wenli Ma, Xingxing Ge, Zhishan Xu, Shumiao Zhang, Xiangdong He, JuanJuan Li, Xiaorong Xia, Xiaobing Chen and Zhe Liu

ACS Omega, 2019, 4, 15240
DOI: 10.1021/acsomega.9b01863

A luminescent microRNA nanoprobe based on the target-triggered release of an iridium(III)-solvent complex from mesoporous silica nanoparticles

Xiaomin Tang, Kaimei Fan, Baohan Qu and Lihua Lu

Microchim Acta, 2019, 186
DOI: 10.1007/s00604-019-3895-6

Inhibition of the CDK9–cyclin T1 protein–protein interaction as a new approach against triple-negative breast cancer

Sha-Sha Cheng, Yuan-Qing Qu, Jia Wu, Guan-Jun Yang, Hao Liu, Wanhe Wang, Qi Huang, Feng Chen, Guodong Li, Chun-Yuen Wong, Vincent Kam Wai Wong, Dik-Lung Ma and Chung-Hang Leung

Acta Pharmaceutica Sinica B, 2022, 12, 1390
DOI: 10.1016/j.apsb.2021.10.024

Anticancer osmium complex inhibitors of the HIF-1α and p300 protein-protein interaction

Chao Yang, Wanhe Wang, Guo-Dong Li, Hai-Jing Zhong, Zhen-Zhen Dong, Chun-Yuen Wong, Daniel W. J. Kwong, Dik-Lung Ma and Chung-Hang Leung

Sci Rep, 2017, 7
DOI: 10.1038/srep42860

Unveiling new horizons: Exploring rhenium and iridium dipyrrinato complexes as luminescent theranostic agents for phototherapy

Neha Manav, Anu Janaagal and Iti Gupta

Coordination Chemistry Reviews, 2024, 511, 215798
DOI: 10.1016/j.ccr.2024.215798

Inhibition of the p53/hDM2 protein-protein interaction by cyclometallated iridium(III) compounds

Li-Juan Liu, Bingyong He, Jennifer A. Miles, Wanhe Wang, Zhifeng Mao, Weng Ian Che, Jin-Jian Lu, Xiu-Ping Chen, Andrew J. Wilson, Dik-Lung Ma and Chung-Hang Leung

Oncotarget, 2016, 7, 13965
DOI: 10.18632/oncotarget.7369

Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine

Olesya A. Kharenko, Reena G. Patel, S. David Brown, Cyrus Calosing, Andre White, Damodharan Lakshminarasimhan, Robert K. Suto, Bryan C. Duffy, Douglas B. Kitchen, Kevin G. McLure, Henrik C. Hansen, Edward H. van der Horst and Peter R. Young

J. Med. Chem., 2018, 61, 8202
DOI: 10.1021/acs.jmedchem.8b00666

Target-based drug discovery: Applications of fluorescence techniques in high throughput and fragment-based screening

Vikrant Kumar, Puneeth Kumar Chunchagatta Lakshman, Thazhe Kootteri Prasad, Kavyashree Manjunath, Sneha Bairy, Akshaya S. Vasu, B. Ganavi, Subbarao Jasti and Neelagandan Kamariah

Heliyon, 2024, 10, e23864
DOI: 10.1016/j.heliyon.2023.e23864

Ruthenium(II) Paracymene complexes of phenolic acids: Synthesis, chemical characterization, in-silico biomolecular interaction and cytotoxicity studies

Sabyasachi Banerjee, Sourav De, S.K. Ashok Kumar, Sankhadip Bose and Subhasis Banerjee

Journal of Inorganic Biochemistry, 2026, 274, 113080
DOI: 10.1016/j.jinorgbio.2025.113080

Isokotomolide A from Cinnamomum kotoense Induce Melanoma Autophagy and Apoptosis In Vivo and In Vitro

Jian Li, Chung-Yi Chen, Jyun Yin Huang, Lin Wang, Zixuan Xu, Wenyi Kang, Miao-Hsia Lin and Hui-Min David Wang

Oxidative Medicine and Cellular Longevity, 2020, 2020, 1
DOI: 10.1155/2020/3425147

Studies on Photocleavage, DNA Binding, Cytotoxicity, and Docking Studies of Ruthenium(II) Mixed Ligand Complexes

Yata Praveen Kumar, C. Shobha Devi, A. Srishailam, N. Deepika, V. Ravi Kumar, P. Venkat Reddy, K Nagasuryaprasad, Surya S. Singh, Penumaka Nagababu and S. Satyanarayana

J Fluoresc, 2016, 26, 2119
DOI: 10.1007/s10895-016-1908-y

A Rhodium(III)-Based Inhibitor of Lysine-Specific Histone Demethylase 1 as an Epigenetic Modulator in Prostate Cancer Cells

Chao Yang, Wanhe Wang, Jia-Xin Liang, Guodong Li, Kasipandi Vellaisamy, Chun-Yuen Wong, Dik-Lung Ma and Chung-Hang Leung

J. Med. Chem., 2017, 60, 2597
DOI: 10.1021/acs.jmedchem.7b00133

Computational Prediction of RNA-Binding Proteins and Binding Sites

Jingna Si, Jing Cui, Jin Cheng and Rongling Wu

IJMS, 2015, 16, 26303
DOI: 10.3390/ijms161125952

A rhodium(III)-based inhibitor of autotaxin with antiproliferative activity

Tian-Shu Kang, Wanhe Wang, Hai-Jing Zhong, Jia-Xin Liang, Chung-Nga Ko, Jin-Jian Lu, Xiu-Ping Chen, Dik-Lung Ma and Chung-Hang Leung

Biochimica et Biophysica Acta (BBA) - General Subjects, 2017, 1861, 256
DOI: 10.1016/j.bbagen.2016.11.032

Ruthenium(II) Complexes with 2-Phenylimidazo[4,5-f][1,10]phenanthroline Derivatives that Strongly Combat Cisplatin-Resistant Tumor Cells

Leli Zeng, Yu Chen, Jiangping Liu, Huaiyi Huang, Ruilin Guan, Liangnian Ji and Hui Chao

Sci Rep, 2016, 6
DOI: 10.1038/srep19449

Hydrogel-based artificial enzyme for combating bacteria and accelerating wound healing

Hao Qiu, Fang Pu, Zhengwei Liu, Xuemeng Liu, Kai Dong, Chaoqun Liu, Jinsong Ren and Xiaogang Qu

Nano Res., 2020, 13, 496
DOI: 10.1007/s12274-020-2636-9

Tripodal Half‐Sandwich Rhodium and Iridium Complexes Containing Sulfonate and Pyridinyl Entities as Antitumor Agents

Andrew R. Burgoyne, Catherine H. Kaschula, M. Iqbal Parker and Gregory S. Smith

Eur J Inorg Chem, 2017, 2017, 5379
DOI: 10.1002/ejic.201700704

Antagonizing STAT5B dimerization with an osmium complex

Li-Juan Liu, Wanhe Wang, Tian-Shu Kang, Jia-Xin Liang, Chenfu Liu, Daniel W. J. Kwong, Vincent Kam Wai Wong, Dik-Lung Ma and Chung-Hang Leung

Sci Rep, 2016, 6
DOI: 10.1038/srep36044

Phytochemical-encapsulated nanoplatform for “on-demand” synergistic treatment of multidrug-resistant bacteria

Panpan Sun, Yan Zhang, Xiang Ran, Chaoying Liu, Zhenzhen Wang, Jinsong Ren and Xiaogang Qu

Nano Res., 2018, 11, 3762
DOI: 10.1007/s12274-017-1947-y

Luminescent ruthenium(II)-para-cymene complexes of aryl substituted imidazo-1,10-phenanthroline as anticancer agents and the effect of remote substituents on cytotoxic activities

Sourav De, R. Selva Kumar, Ashna Gauthaman, S.K. Ashok Kumar, Priyankar Paira, Anbalagan Moorthy and Subhasis Banerjee

Inorganica Chimica Acta, 2021, 515, 120066
DOI: 10.1016/j.ica.2020.120066

Phosphorescent iridium(III) complexes containing bis(diphenylphorothioyl)amide ligands for the detection of Hg2+ ions and cysteine

Jia-Xin Zhang, Wen-Hao Li, Yi-Chuan Huang, Zhen-Qiang Qin and Hong-Yan Li

Dyes and Pigments, 2024, 222, 111922
DOI: 10.1016/j.dyepig.2023.111922

Acidity-responsive phosphorescent metal complexes for cancer imaging and theranostic applications

Liang Hao, Yan-Mei Zhong, Cai-Ping Tan and Zong-Wan Mao

Journal of Organometallic Chemistry, 2021, 943, 121821
DOI: 10.1016/j.jorganchem.2021.121821

An optimized BRD4 inhibitor effectively eliminates NF-κB-driven triple-negative breast cancer cells

Guan-Jun Yang, Ying-Qi Song, Wanhe Wang, Quan-Bin Han, Dik-Lung Ma and Chung-Hang Leung

Bioorganic Chemistry, 2021, 114, 105158
DOI: 10.1016/j.bioorg.2021.105158

Mimicking Strategy for Protein–Protein Interaction Inhibitor Discovery by Virtual Screening

Ke-Jia Wu, Pui-Man Lei, Hao Liu, Chun Wu, Chung-Hang Leung and Dik-Lung Ma

Molecules, 2019, 24, 4428
DOI: 10.3390/molecules24244428

Potential anticancer agent for selective damage to mitochondria or lysosomes: Naphthalimide-modified fluorescent biomarker half-sandwich iridium (III) and ruthenium (II) complexes

Wenli Ma, Shumiao Zhang, Zhenzhen Tian, Zhishan Xu, Yujiao Zhang, Xiaorong Xia, Xiaobing Chen and Zhe Liu

European Journal of Medicinal Chemistry, 2019, 181, 111599
DOI: 10.1016/j.ejmech.2019.111599

Crystal structure and thermal properties of K3[Ir(C2O4)3]·4.25H2O and K3[Ir(C2O4)3]·0.5KCl·4H2O

Ilia V. Kochetygov, Evgeny Yu. Filatov, Natalia V. Kuratieva, Pavel E. Plyusnin, Dmitry Yu. Naumov, Andrey V. Zadesenets, Sergey V. Korenev, Alphiya R. Tsygankova and Vladimir A. Logvinenko

J Therm Anal Calorim, 2016, 126, 1541
DOI: 10.1007/s10973-016-5687-0

SMYD5-BRD4 Interaction Drives Hepatocellular Carcinoma Progression: A Combined in Silico and Experimental Analysis

Mingye Hu, Shiji Chen, Yumiao Zhen, Xin Wang, Yiwen Zhong, Xiaoxu Liang, Cheong-Meng Chong and Hai-Jing Zhong

Pharmaceuticals, 2025, 18, 1105
DOI: 10.3390/ph18081105

Liposomes encapsulated iridium(III) polypyridyl complexes enhance anticancer activity in vitro and in vivo

Lan Bai, Wei-Dong Fei, Yi-Ying Gu, Miao He, Fan Du, Wen-Yao Zhang, Lin-Lin Yang and Yun-Jun Liu

Journal of Inorganic Biochemistry, 2020, 205, 111014
DOI: 10.1016/j.jinorgbio.2020.111014

Orange/red light emitting iridium(III) organometallic complexes containing 2,3‐di(pyridine‐2‐yl)quinoxaline as ancillary ligand and their anticancer properties

Kahnu Charan Pradhan, Madhusmita Jadab, Smrutirekha Rout, Rambabu Dandela, Deepa Mandal, Tithi Parija, Sahadev Barik, Jagadish Kumar and Satyanarayan Pal

Zeitschrift anorg allge chemie, 2023, 649
DOI: 10.1002/zaac.202300169

Cytotoxic Activities of Bis‐cyclometalated Iridium(III) Complexes Containing Chloro‐substituted κ2N‐terpyridines

Marion Graf, Hans‐Christian Böttcher, Peter Mayer, Nils Metzler‐Nolte, Sugina Thavalingam and Rafał Czerwieniec

Zeitschrift anorg allge chemie, 2022, 648
DOI: 10.1002/zaac.202200047

Mitochondria-localizing curcumin-cryptolepine Zn(II) complexes and their antitumor activity

Li-Qin Qin, Chun-Jie Liang, Zhen Zhou, Qi-Pin Qin, Zu-Zhuang Wei, Ming-Xiong Tan and Hong Liang

Bioorganic & Medicinal Chemistry, 2021, 30, 115948
DOI: 10.1016/j.bmc.2020.115948

Profound, durable and MGMT‐independent sensitivity of glioblastoma cells to cyclin‐dependent kinase inhibition

Emilie Le Rhun, Caroline von Achenbach, Birthe Lohmann, Manuela Silginer, Hannah Schneider, Kristan Meetze, Emese Szabo and Michael Weller

Intl Journal of Cancer, 2019, 145, 242
DOI: 10.1002/ijc.32069

The design and development of covalent protein-protein interaction inhibitors for cancer treatment

Sha-Sha Cheng, Guan-Jun Yang, Wanhe Wang, Chung-Hang Leung and Dik-Lung Ma

J Hematol Oncol, 2020, 13
DOI: 10.1186/s13045-020-00850-0

Development of a Long-Lived Luminescence Probe for Visualizing β-Galactosidase in Ovarian Carcinoma Cells

Wanhe Wang, Kasipandi Vellaisamy, Guodong Li, Chun Wu, Chung-Nga Ko, Chung-Hang Leung and Dik-Lung Ma

Anal. Chem., 2017, 89, 11679
DOI: 10.1021/acs.analchem.7b03114

Discovery of a tetrahydroisoquinoline-based CDK9-cyclin T1 protein–protein interaction inhibitor as an anti-proliferative and anti-migration agent against triple-negative breast cancer cells

Shasha Cheng, Guan-Jun Yang, Wanhe Wang, Dik-Lung Ma and Chung-Hang Leung

Genes & Diseases, 2022, 9, 1674
DOI: 10.1016/j.gendis.2021.06.005

Synthesis and Biological Investigation of (+)-JD1, an Organometallic BET Bromodomain Inhibitor

Storm Hassell-Hart, Andrew Runcie, Tobias Krojer, Jordan Doyle, Ella Lineham, Cory A. Ocasio, Brenno A. D. Neto, Oleg Fedorov, Graham Marsh, Hannah Maple, Robert Felix, Rebecca Banks, Alessio Ciulli, Sarah Picaud, Panagis Filippakopoulos, Frank von Delft, Paul Brennan, Helen J. S. Stewart, Timothy J. Chevassut, Martin Walker, Carol Austin, Simon Morley and John Spencer

Organometallics, 2020, 39, 408
DOI: 10.1021/acs.organomet.9b00750

Cyclometalated iridium(III) luminescent complexes in therapy and phototherapy

Ana Zamora, Gloria Vigueras, Venancio Rodríguez, M. Dolores Santana and José Ruiz

Coordination Chemistry Reviews, 2018, 360, 34
DOI: 10.1016/j.ccr.2018.01.010

The in vitro antitumor activity of oligonuclear polypyridyl rhodium and iridium complexes against cancer cells and human pathogens

Basava Punna Rao A, Uma A, Chiranjeevi T, M.S. Bethu, Venkateswara Rao J, Debojit Kumar Deb, Biplab Sarkar, Werner Kaminsky and Mohan Rao Kollipara

Journal of Organometallic Chemistry, 2016, 824, 131
DOI: 10.1016/j.jorganchem.2016.10.018

An Iridium(III) Complex as a Photoactivatable Tool for Oxidation of Amyloidogenic Peptides with Subsequent Modulation of Peptide Aggregation

Juhye Kang, Shin Jung C. Lee, Jung Seung Nam, Hyuck Jin Lee, Myeong‐Gyun Kang, Kyle J. Korshavn, Hyun‐Tak Kim, Jaeheung Cho, Ayyalusamy Ramamoorthy, Hyun‐Woo Rhee, Tae‐Hyuk Kwon and Mi Hee Lim

Chemistry A European J, 2017, 23, 1645
DOI: 10.1002/chem.201604751

Inhibitors of bromodomain and extra‐terminal proteins for treating multiple human diseases

Ewelina Kulikowski, Brooke D. Rakai and Norman C. W. Wong

Medicinal Research Reviews, 2021, 41, 223
DOI: 10.1002/med.21730

Exploring the Effect of Polypyridyl Ligands on the Anticancer Activity of Phosphorescent Iridium(III) Complexes: From Proteosynthesis Inhibitors to Photodynamic Therapy Agents

Jitka Pracharova, Gloria Vigueras, Vojtech Novohradsky, Natalia Cutillas, Christoph Janiak, Hana Kostrhunova, Jana Kasparkova, José Ruiz and Viktor Brabec

Chemistry A European J, 2018, 24, 4607
DOI: 10.1002/chem.201705362

Targeting emerging cancer hallmarks by transition metal complexes: Epigenetic reprogramming and epitherapies. Part II

Jemma Arakelyan, Daniil A. Rusanov, Meng Rui Chang, Aleksandra V. Asaturova, Galina S. Kireeva, Mana Alshehri, Wee Han Ang and Maria V. Babak

Coordination Chemistry Reviews, 2023, 475, 214899
DOI: 10.1016/j.ccr.2022.214899

Inhibitors of protein–protein interactions (PPIs): an analysis of scaffold choices and buried surface area

Xu Ran and Jason E Gestwicki

Current Opinion in Chemical Biology, 2018, 44, 75
DOI: 10.1016/j.cbpa.2018.06.004

Discovery of a Copper-Based Mcl-1 Inhibitor as an Effective Antitumor Agent

Xing Lu, Yan-Cheng Liu, Chris Orvig, Hong Liang and Zhen-Feng Chen

J. Med. Chem., 2020, 63, 9154
DOI: 10.1021/acs.jmedchem.9b02047

Activity Enhancement of G‐Quadruplex/Hemin DNAzyme by Flanking d(CCC)

Tianjun Chang, Hongmei Gong, Pi Ding, Xiangjun Liu, Weiguo Li, Tao Bing, Zehui Cao and Dihua Shangguan

Chemistry A European J, 2016, 22, 4015
DOI: 10.1002/chem.201504797

Probing BRD Inhibition Substituent Effects in Bulky Analogues of (+)‐JQ1

Storm Hassell‐Hart, Sarah Picaud, Raphael Lengacher, Joshua Csucker, Regis Millet, Gilles Gasser, Roger Alberto, Hannah Maple, Robert Felix, Zbigniew J. Leśnikowski, Helen J. S. Stewart, Timothy J. Chevassut, Simon Morley, Panagis Filippakopoulos and John Spencer

Helvetica Chimica Acta, 2021, 104
DOI: 10.1002/hlca.202000214

Discovery of an Orally Selective Inhibitor of Signal Transducer and Activator of Transcription 3 Using Advanced Multiple Ligand Simultaneous Docking

Wenying Yu, Chenglong Li, Wenda Zhang, Yuanzheng Xia, Shanshan Li, Jia-yuh Lin, Keqin Yu, Mu Liu, Lei Yang, Jianguang Luo, Yijun Chen, Hongbin Sun and Lingyi Kong

J. Med. Chem., 2017, 60, 2718
DOI: 10.1021/acs.jmedchem.6b01489

Direct Targeting of Gene Regulators by Iridium(III) and Rhodium(III) Complexes

Lei Wu, Lingtan Kong, Wanhe Wang and Chung-Hang Leung

Acc. Chem. Res., 2025, 58, 3364
DOI: 10.1021/acs.accounts.5c00570

A Ruthenium(II) Complex Inhibits BRD4 for Synergistic Seno‐ and Chemo‐Immunotherapy in Cisplatin‐Resistant Tumor Cells

Jinrong Yang, Fa Wang, Shuqi Huang, Tao Feng, Kai Xiong, Yu Chen and Hui Chao

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202505689

Organometallic d6, d8 and d10 metal complexes for biosensing and imaging, cancer therapy and theranosis

Yam-Yuet Lam, Nga-Sze Lee, Shun-Fung Lee and Clive Yik-Sham Chung

Journal of Organometallic Chemistry, 2024, 1005, 122982
DOI: 10.1016/j.jorganchem.2023.122982

Recent advances in biological activities of rhodium complexes: Their applications in drug discovery research

Marzieh Sohrabi, Mina Saeedi, Bagher Larijani and Mohammad Mahdavi

European Journal of Medicinal Chemistry, 2021, 216, 113308
DOI: 10.1016/j.ejmech.2021.113308

Identification of SNAIL1 Peptide-Based Irreversible Lysine-Specific Demethylase 1-Selective Inactivators

Yukihiro Itoh, Keisuke Aihara, Paolo Mellini, Toshifumi Tojo, Yosuke Ota, Hiroki Tsumoto, Viswas Raja Solomon, Peng Zhan, Miki Suzuki, Daisuke Ogasawara, Akira Shigenaga, Tsubasa Inokuma, Hidehiko Nakagawa, Naoki Miyata, Tamio Mizukami, Akira Otaka and Takayoshi Suzuki

J. Med. Chem., 2016, 59, 1531
DOI: 10.1021/acs.jmedchem.5b01323

Domain structure of CoIr nanoalloys

Evgeny Yu. Filatov, Svetlana V. Cherepanova, Ilia V. Kochetygov, Yury V. Shubin and Sergey V. Korenev

Powder Diffr., 2017, 32, S155
DOI: 10.1017/S0885715617000367

Recent discoveries of the role of histone modifications and related inhibitors in pathological cardiac hypertrophy

Ke-Jia Wu, Qi Chen, Chung-Hang Leung, Ning Sun, Fei Gao and Zhaoyang Chen

Drug Discovery Today, 2024, 29, 103878
DOI: 10.1016/j.drudis.2024.103878

Iridium(III) complexes as novel theranostic small molecules for medical diagnostics, precise imaging at a single cell level and targeted anticancer therapy

Patryk Szymaszek, Małgorzata Tyszka-Czochara and Joanna Ortyl

European Journal of Medicinal Chemistry, 2024, 276, 116648
DOI: 10.1016/j.ejmech.2024.116648

Inorganic Nanomaterials Used in Anti-Cancer Therapies:Further Developments

Olga Długosz, Wiktoria Matyjasik, Gabriela Hodacka, Krzysztof Szostak, Julia Matysik, Patrycja Krawczyk, Anna Piasek, Jolanta Pulit-Prociak and Marcin Banach

Nanomaterials, 2023, 13, 1130
DOI: 10.3390/nano13061130

Targeting Bromodomain-Selective Inhibitors of BET Proteins in Drug Discovery and Development

Juncheng Chen, Pan Tang, Yuxi Wang, Jiaxing Wang, Chengcan Yang, Yang Li, Gaoxia Yang, Fengbo Wu, Jifa Zhang and Liang Ouyang

J. Med. Chem., 2022, 65, 5184
DOI: 10.1021/acs.jmedchem.1c01835

Luminescent Iridium(III) Complex Labeled DNA for Graphene Oxide-Based Biosensors

Qingcheng Zhao, Yuyang Zhou, Yingying Li, Wei Gu, Qi Zhang and Jian Liu

Anal. Chem., 2016, 88, 1892
DOI: 10.1021/acs.analchem.5b04324

Affinity-guided protein conjugation: the trilogy of covalent protein labeling, assembly and inhibition

Yongsheng Yu and Jiang Xia

Sci. China Chem., 2016, 59, 853
DOI: 10.1007/s11426-016-5571-6

Developing an Anticancer Platinum(II) Compound Based on the Uniqueness of Human Serum Albumin

Zhenlei Zhang, Juzheng Zhang, Tongfu Yang, Shanhe Li, Gang Xu, Hong Liang and Feng Yang

J. Med. Chem., 2023, 66, 5669
DOI: 10.1021/acs.jmedchem.3c00001

Potential biomedical applications of marine algae

Hui-Min David Wang, Xiao-Chun Li, Duu-Jong Lee and Jo-Shu Chang

Bioresource Technology, 2017, 244, 1407
DOI: 10.1016/j.biortech.2017.05.198

Luminescent Strategies for Label‐Free G‐Quadruplex‐Based Enzyme Activity Sensing

Dik‐Lung Ma, Zhen‐Zhen Dong, Kasipandi Vellaisamy, Ka‐Man Cheung, Guanjun Yang and Chung‐Hang Leung

The Chemical Record, 2017, 17, 1135
DOI: 10.1002/tcr.201700014

Identification of an Iridium(III)-Based Inhibitor of Tumor Necrosis Factor-α

Tian-Shu Kang, Zhifeng Mao, Chan-Tat Ng, Modi Wang, Wanhe Wang, Chunming Wang, Simon Ming-Yuen Lee, Yitao Wang, Chung-Hang Leung and Dik-Lung Ma

J. Med. Chem., 2016, 59, 4026
DOI: 10.1021/acs.jmedchem.6b00112

Facilely Fabricating Bimetallic Ir/Co Nanozymes with High Oxidize-like Activities for Sensitive Detection of Malathion with Portable Swabs

Menghan Liu, Ruyu Zhang, Jie Wang, Huiting Zhang, Jingying Tan, Qingzhi Liu, Lei Han and Lihua Lu

Anal. Chem., 2025, 97, 13404
DOI: 10.1021/acs.analchem.5c01779