Synthesis and biological activity evaluation of 20-epi-salinomycin and its 20-O-acyl derivatives

Wenxuan Zhang, Jun Wu, Bo Li, Jie Xia, Hongna Wu, Liu Wang, Jie Hao, Qi Zhou and Song Wu

RSC Adv., 2016, 6, 41885
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Discovery of a 19F MRI sensitive salinomycin derivative with high cytotoxicity towards cancer cells

Qiuyan Shi, Yu Li, Shaowei Bo, Xiaofei Li, Peng Zhao, Qi Liu, Zhigang Yang, Hengjiang Cong, Hexiang Deng, Mingnan Chen, Shizhen Chen, Xin Zhou, Hong Ding and Zhong-Xing Jiang

Chem. Commun., 2016, 52, 5136
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An extremely efficient and green method for the acylation of secondary alcohols, phenols and naphthols with a deep eutectic solvent as the catalyst

Hai Truong Nguyen and Phuong Hoang Tran

RSC Adv., 2016, 6, 98365
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Synthesis and anti-tumor activity evaluation of salinomycin C20-O-alkyl/benzyl oxime derivatives

Bo Li, Jun Wu, Lei Tang, Xu Lian, Zhongwen Li, Wenfang Duan, Tong Qin, Xintong Zhao, Yuhua Hu, Chi Zhang, Tianlei Li, Jie Hao, Wenxuan Zhang, Jihong Zhang and Song Wu

Org. Biomol. Chem., 2022, 20, 870
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Structure–activity & structure–toxicity relationship study of salinomycin diastereoisomers and their benzoylated derivatives

Wenxuan Zhang, Jun Wu, Bo Li, Hongna Wu, Liu Wang, Jie Hao, Song Wu and Qi Zhou

Org. Biomol. Chem., 2016, 14, 2840
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Therapeutic vulnerabilities of cancer stem cells and effects of natural products

Keighley N. Reisenauer, Jaquelin Aroujo, Yongfeng Tao, Santhalakshmi Ranganathan, Daniel Romo and Joseph H. Taube

Nat. Prod. Rep., 2023, 40, 1432
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Evaluation of the anticancer activity of singly and doubly modified analogues of C20-epi-salinomycin

Dominika Czerwonka, Magdalena Mielczarek-Puta, Michał Antoszczak, Aleksandra Cioch, Marta Struga and Adam Huczyński

European Journal of Pharmacology, 2021, 908, 174347
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Salinomycin Derivatives Kill Breast Cancer Stem Cells by Lysosomal Iron Targeting

Antoine Versini, Ludovic Colombeau, Antje Hienzsch, Christine Gaillet, Pascal Retailleau, Sylvain Debieu, Sebastian Müller, Tatiana Cañeque and Raphaël Rodriguez

Chemistry A European J, 2020, 26, 7416
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Design and synthesis of conformationally constrained salinomycin derivatives

Wenxuan Zhang, Jun Wu, Bo Li, Xu Lian, Jie Xia, Qi Zhou and Song Wu

European Journal of Medicinal Chemistry, 2017, 138, 353
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Current report of natural product development against breast cancer stem cells

Adam Hermawan and Herwandhani Putri

The International Journal of Biochemistry & Cell Biology, 2018, 104, 114
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Synthesis of chemical tools to improve water solubility and promote the delivery of salinomycin to cancer cells

Loay Awad

Exp Ther Med, 2019
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Site‐Specific Modification of the Anticancer and Antituberculosis Polyether Salinomycin by Biosynthetic Engineering

Hanna Luhavaya, Simon R. Williams, Hui Hong, Luciana Gonzaga de Oliveira and Peter F. Leadlay

ChemBioChem, 2014, 15, 2081
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Semi-synthetic salinomycin analogs exert cytotoxic activity against human colorectal cancer stem cells

Johannes Klose, Sarah Kattner, Björn Borgström, Claudia Volz, Thomas Schmidt, Martin Schneider, Stina Oredsson, Daniel Strand and Alexis Ulrich

Biochemical and Biophysical Research Communications, 2018, 495, 53
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Synthesis and Anticancer Activity of Dimeric Polyether Ionophores

Michał Sulik, Ewa Maj, Joanna Wietrzyk, Adam Huczyński and Michał Antoszczak

Biomolecules, 2020, 10, 1039
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Breast cancer stem cell selectivity of synthetic nanomolar-active salinomycin analogs

Xiaoli Huang, Björn Borgström, Sebastian Kempengren, Lo Persson, Cecilia Hegardt, Daniel Strand and Stina Oredsson

BMC Cancer, 2016, 16
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Singly and doubly modified analogues of C20-epi-salinomycin: A new group of antiparasitic agents against Trypanosoma brucei

Dominika Czerwonka, Yzobelle Barcelos, Dietmar Steverding, Aleksandra Cioch, Adam Huczyński and Michał Antoszczak

European Journal of Medicinal Chemistry, 2021, 209, 112900
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Effect of stereochemistry at position C20 on the antiproliferative activity and selectivity of N-acylated derivatives of salinomycin

Michał Antoszczak, Julia Krzywik, Greta Klejborowska, Michał Sulik, Szymon Sobczak, Dominika Czerwonka, Ewa Maj, Małgorzata Ullrich, Tomasz Sobierajski, Jarosław Sukiennik, Joanna Wietrzyk, Witold Mozga, Przemysław Pilaszek and Adam Huczyński

European Journal of Medicinal Chemistry, 2025, 291, 117598
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Synthesis and biological activity of salinomycin-hydroxamic acid conjugates

Bo Li, Jun Wu, Wenxuan Zhang, Zhongwen Li, Gang Chen, Qi Zhou and Song Wu

Bioorganic & Medicinal Chemistry Letters, 2017, 27, 1624
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A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents

Michał Antoszczak

European Journal of Medicinal Chemistry, 2019, 166, 48
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The Molecular Basis for Inhibition of Stemlike Cancer Cells by Salinomycin

Xiaoli Huang, Björn Borgström, John Stegmayr, Yasmin Abassi, Monika Kruszyk, Hakon Leffler, Lo Persson, Sebastian Albinsson, Ramin Massoumi, Ivan G. Scheblykin, Cecilia Hegardt, Stina Oredsson and Daniel Strand

ACS Cent. Sci., 2018, 4, 760
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Salinomycin Hydroxamic Acids: Synthesis, Structure, and Biological Activity of Polyether Ionophore Hybrids

Björn Borgström, Xiaoli Huang, Eduard Chygorin, Stina Oredsson and Daniel Strand

ACS Med. Chem. Lett., 2016, 7, 635
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Urea and Thiourea Derivatives of Salinomycin as Agents Targeting Malignant Colon Cancer Cells

Michal Antoszczak, Magdalena Mielczarek-Puta, Marta Struga and Adam Huczynski

ACAMC, 2025, 25, 330
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Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives

Yu Li, Qiuyan Shi, Jiajia Shao, Yaping Yuan, Zhigang Yang, Shizhen Chen, Xin Zhou, Shijun Wen and Zhong-Xing Jiang

European Journal of Medicinal Chemistry, 2018, 148, 279
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Iron-Sensitive Prodrugs That Trigger Active Ferroptosis in Drug-Tolerant Pancreatic Cancer Cells

Michał Antoszczak, Sebastian Müller, Tatiana Cañeque, Ludovic Colombeau, Nelson Dusetti, Patricia Santofimia-Castaño, Christine Gaillet, Alain Puisieux, Juan Lucio Iovanna and Raphaël Rodriguez

J. Am. Chem. Soc., 2022, 144, 11536
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A Concise Review of Prodigious Salinomycin and Its Derivatives Effective in Treatment of Breast Cancer: (2012–2022)

Viren Soni, Akhil Nagar, Ruchita Bardiya, Jacob Mara, Lukas Von Suskil, Sabrina Rose and Chetankumar Sonawane

IJTM, 2023, 3, 217
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Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models

Alicja Urbaniak, Megan R. Reed, Daniel Fil, Anika Moorjani, Sarah Heflin, Michał Antoszczak, Michał Sulik, Adam Huczyński, Michalina Kupsik, Robert L. Eoff, Melanie C. MacNicol, Timothy C. Chambers and Angus M. MacNicol

Biomedicine & Pharmacotherapy, 2021, 141, 111815
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Salinomycin derivatives exhibit activity against primary acute lymphoblastic leukemia (ALL) cells in vitro

Alicja Urbaniak, Magdalena Delgado, Michał Antoszczak, Adam Huczyński and Timothy C. Chambers

Biomedicine & Pharmacotherapy, 2018, 99, 384
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Synthesis and Anticancer Activity of Tertiary Amides of Salinomycin and Their C20‐oxo Analogues

Dominika Czerwonka, Alicja Urbaniak, Szymon Sobczak, Sergio Piña‐Oviedo, Timothy C. Chambers, Michał Antoszczak and Adam Huczyński

ChemMedChem, 2020, 15, 236
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Salinomycin and its derivatives – A new class of multiple-targeted “magic bullets”

Michał Antoszczak and Adam Huczyński

European Journal of Medicinal Chemistry, 2019, 176, 208
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Rapid Access to Ironomycin Derivatives by Click Chemistry

Michał Antoszczak, Sebastian Müller, Ludovic Colombeau, Tatiana Cañeque and Raphaël Rodriguez

ACS Org. Inorg. Au, 2022, 2, 222
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Salinomycin kills cancer stem cells by sequestering iron in lysosomes

Trang Thi Mai, Ahmed Hamaï, Antje Hienzsch, Tatiana Cañeque, Sebastian Müller, Julien Wicinski, Olivier Cabaud, Christine Leroy, Amandine David, Verónica Acevedo, Akihide Ryo, Christophe Ginestier, Daniel Birnbaum, Emmanuelle Charafe-Jauffret, Patrice Codogno, Maryam Mehrpour and Raphaël Rodriguez

Nature Chem, 2017, 9, 1025
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Expeditive Synthesis of Potent C20-epi-Amino Derivatives of Salinomycin against Cancer Stem-Like Cells

Dominika Czerwonka, Sebastian Müller, Tatiana Cañeque, Ludovic Colombeau, Adam Huczyński, Michał Antoszczak and Raphaël Rodriguez

ACS Org. Inorg. Au, 2022, 2, 214
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Synthesis and antiproliferative activity of new bioconjugates of Salinomycin with amino acid esters

Michał Antoszczak, Maria Sobusiak, Ewa Maj, Joanna Wietrzyk and Adam Huczyński

Bioorganic & Medicinal Chemistry Letters, 2015, 25, 3511
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Rate of translocation across lipid bilayer of triphenylphosphonium-linked salinomycin derivatives contributes significantly to their K+/H+ exchange activity on membranes

Yuri N. Antonenko, Marta Jędrzejczyk, Tatyana I. Rokitskaya, Ljudmila S. Khailova, Elena A. Kotova and Adam Huczyński

Bioelectrochemistry, 2022, 145, 108089
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Fluorinated C20‐epi‐Deoxysalinomycin Derivatives: Synthesis and Evaluation of Anticancer Activities

Jing Zhang, Min Sun, Zhigang Yang, Zhong‐Xing Jiang and Yu Li

Chemistry & Biodiversity, 2025
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Synthesis and biological evaluation of salinomycin triazole analogues as anticancer agents

Minjian Huang, Zixin Deng, Jian Tian and Tiangang Liu

European Journal of Medicinal Chemistry, 2017, 127, 900
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Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin

Michał Antoszczak, Ewa Maj, Joanna Stefańska, Joanna Wietrzyk, Jan Janczak, Bogumil Brzezinski and Adam Huczyński

Bioorganic & Medicinal Chemistry Letters, 2014, 24, 1724
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Anti-trypanosomal activity of doubly modified salinomycin derivatives

Michał Antoszczak, Dietmar Steverding, Michał Sulik, Jan Janczak and Adam Huczyński

European Journal of Medicinal Chemistry, 2019, 173, 90
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Chemical biology of salinomycin

Antoine Versini, Lou Saier, Fabien Sindikubwabo, Sebastian Müller, Tatiana Cañeque and Raphaël Rodriguez

Tetrahedron, 2018, 74, 5585
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Bivalent polyether ionophores: Synthesis and biological evaluation of C2-symmetric salinomycin dimers

Michał Antoszczak, Ewa Maj, Björn Borgström, Stina Oredsson, Adam Huczyński, Joanna Wietrzyk and Daniel Strand

Tetrahedron Letters, 2017, 58, 2396
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Synthesis, Anticancer and Antibacterial Activity of Salinomycin N-Benzyl Amides

Michał Antoszczak, Ewa Maj, Agnieszka Napiórkowska, Joanna Stefańska, Ewa Augustynowicz-Kopeć, Joanna Wietrzyk, Jan Janczak, Bogumil Brzezinski and Adam Huczyński

Molecules, 2014, 19, 19435
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A medicinal chemistry perspective on salinomycin as a potent anticancer and anti-CSCs agent

Michał Antoszczak

European Journal of Medicinal Chemistry, 2019, 164, 366
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Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model

Johannes Klose, Stefan Trefz, Tobias Wagner, Luca Steffen, Arsalie Preißendörfer Charrier, Praveen Radhakrishnan, Claudia Volz, Thomas Schmidt, Alexis Ulrich, Sebastian M. Dieter, Claudia Ball, Hanno Glimm, Martin Schneider and Joseph Najbauer

PLoS ONE, 2019, 14, e0211916
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Semisynthesis of SY-1 for Investigation of Breast Cancer Stem Cell Selectivity of C-Ring-Modified Salinomycin Analogues

Xiaoli Huang, Björn Borgström, Linda Månsson, Lo Persson, Stina Oredsson, Cecilia Hegardt and Daniel Strand

ACS Chem. Biol., 2014, 9, 1587
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Salinomycin as a potent anticancer stem cell agent: State of the art and future directions

Dan Qi, Yunyi Liu, Juan Li, Jason H. Huang, Xiaoxiao Hu and Erxi Wu

Medicinal Research Reviews, 2022, 42, 1037
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Synthesis of urea and thiourea derivatives of C20-epi-aminosalinomycin and their activity against Trypanosoma brucei

Michał Antoszczak, Kieran Gadsby-Davis, Dietmar Steverding and Adam Huczyński

European Journal of Medicinal Chemistry, 2023, 250, 115241
DOI: 10.1016/j.ejmech.2023.115241

Synthesis, cytotoxicity and antibacterial activity of new esters of polyether antibiotic – salinomycin

Michał Antoszczak, Katarzyna Popiel, Joanna Stefańska, Joanna Wietrzyk, Ewa Maj, Jan Janczak, Greta Michalska, Bogumil Brzezinski and Adam Huczyński

European Journal of Medicinal Chemistry, 2014, 76, 435
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Simultaneous targeting of DNA replication and homologous recombination in glioblastoma with a polyether ionophore

Yi Chieh Lim, Kathleen S Ensbey, Carolin Offenhäuser, Rochelle C J D’souza, Jason K Cullen, Brett W Stringer, Hazel Quek, Zara C Bruce, Amanda Kijas, Valentina Cianfanelli, Bijan Mahboubi, Fiona Smith, Rosalind L Jeffree, Lisa Wiesmüeller, Adrian P Wiegmans, Amanda Bain, Fanny J Lombard, Tara L Roberts, Kum Kum Khanna, Martin F Lavin, Baek Kim, Petra Hamerlik, Terrance G Johns, Mark J Coster, Andrew W Boyd and Bryan W Day

Neuro-Oncology, 2019
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Effective Synthesis of C20‐Epi‐Isothiocyanato‐Salinomycin and its Thiourea Derivatives as Potential Anticancer Agents

Rui Jiang, Xin Zhang, Na Li, Yuyin Mao, Huan Chen, Zhouming Deng, Wentao Wang, Zhong‐Xing Jiang, Liying Xu and Zhigang Yang

Chemistry A European J, 2024, 30
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Structure–Activity Relationships in Salinomycin: Cytotoxicity and Phenotype Selectivity of Semi‐synthetic Derivatives

Björn Borgström, Xiaoli Huang, Cecilia Hegardt, Stina Oredsson and Daniel Strand

Chemistry A European J, 2017, 23, 2077
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One‐pot synthesis and antiproliferative activity of novel double‐modified derivatives of the polyether ionophore monensin A

Greta Klejborowska, Ewa Maj, Joanna Wietrzyk, Joanna Stefańska and Adam Huczyński

Chem Biol Drug Des, 2018, 92, 1537
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A new animal product free defined medium for 2D and 3D culturing of normal and cancer cells to study cell proliferation and migration as well as dose response to chemical treatment

Ólöf Birna Rafnsdóttir, Anna Kiuru, Mattis Tebäck, Nathalie Friberg, Philippa Revstedt, Johan Zhu, Sofia Thomasson, Agnieszka Czopek, Atena Malakpour-Permlid, Tilo Weber and Stina Oredsson

Toxicology Reports, 2023, 10, 509
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Synthesis and biological activity of salinomycin conjugates with floxuridine

Adam Huczyński, Michał Antoszczak, Natalia Kleczewska, Marta Lewandowska, Ewa Maj, Joanna Stefańska, Joanna Wietrzyk, Jan Janczak and Lech Celewicz

European Journal of Medicinal Chemistry, 2015, 93, 33
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Spectroscopic and structural studies of the first complex formed between salinomycin and organic amine

Michał Antoszczak, Jan Janczak, Bogumił Brzezinski and Adam Huczyński

Journal of Molecular Structure, 2017, 1130, 719
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Spectroscopic and structural studies of a new para-iodo-N-benzyl amide of salinomycin

Michał Antoszczak, Jan Janczak, Jacek Rutkowski, Bogumił Brzezinski and Adam Huczyński

Journal of Molecular Structure, 2017, 1147, 197
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Biological activity of doubly modified salinomycin analogs – Evaluation in vitro and ex vivo

Michał Antoszczak, Alicja Urbaniak, Magdalena Delgado, Ewa Maj, Björn Borgström, Joanna Wietrzyk, Adam Huczyński, Youzhong Yuan, Timothy C. Chambers and Daniel Strand

European Journal of Medicinal Chemistry, 2018, 156, 510
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A novel 3D polycaprolactone high-throughput system for evaluation of toxicity in normoxia and hypoxia

Atena Malakpour-Permlid and Stina Oredsson

Toxicology Reports, 2021, 8, 627
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Activity of singly and doubly modified derivatives of C20-epi-salinomycin against Staphylococcus strains

Dominika Czerwonka, Małgorzata Podsiad, Joanna Stefańska, Michał Antoszczak and Adam Huczyński

J Antibiot, 2022, 75, 445
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