Exploring viscosity, polarity and temperature sensitivity of BODIPY-based molecular rotors

Aurimas Vyšniauskas, Ismael López-Duarte, Nicolas Duchemin, Thanh-Truc Vu, Yilei Wu, Ekaterina M. Budynina, Yulia A. Volkova, Eduardo Peña Cabrera, Diana E. Ramírez-Ornelas and Marina K. Kuimova

Phys. Chem. Chem. Phys., 2017, 19, 25252
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Tuning BODIPY molecular rotors into the red: sensitivity to viscosity vs. temperature

Thanh Truc Vu, Rachel Méallet-Renault, Gilles Clavier, Boris A. Trofimov and Marina K. Kuimova

J. Mater. Chem. C, 2016, 4, 2828
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Lipophilic molecular rotor to assess the viscosity of oil core in nano-emulsion droplets

Mohamed Elhassan, Carla Faivre, Halina Anton, Guillaume Conzatti, Pascal Didier, Thierry Vandamme, Alteyeb S. Elamin, Mayeul Collot and Nicolas Anton

Soft Matter, 2025, 21, 1212
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Macro-/micro-environment-sensitive chemosensing and biological imaging

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Chem. Soc. Rev., 2014, 43, 4563
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Direct imaging of changes in aerosol particle viscosity upon hydration and chemical aging

N. A. Hosny, C. Fitzgerald, A. Vyšniauskas, A. Athanasiadis, T. Berkemeier, N. Uygur, U. Pöschl, M. Shiraiwa, M. Kalberer, F. D. Pope and M. K. Kuimova

Chem. Sci., 2016, 7, 1357
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Designing a green-emitting viscosity-sensitive 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) probe for plasma membrane viscosity imaging

Artūras Polita, Milda Stancikaitė, Rokas Žvirblis, Karolina Maleckaitė, Jelena Dodonova-Vaitkūnienė, Sigitas Tumkevičius, Arun Prabha Shivabalan and Gintaras Valinčius

RSC Adv., 2023, 13, 19257
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Imaging plasma membrane phase behaviour in live cells using a thiophene-based molecular rotor

Michael R. Dent, Ismael López-Duarte, Callum J. Dickson, Phoom Chairatana, Harry L. Anderson, Ian R. Gould, Douglas Wylie, Aurimas Vyšniauskas, Nicholas J. Brooks and Marina K. Kuimova

Chem. Commun., 2016, 52, 13269
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Fluorescent lifetime imaging of atmospheric aerosols: a direct probe of aerosol viscosity

Neveen A. Hosny, Clare Fitzgerald, Changlun Tong, Markus Kalberer, Marina K. Kuimova and Francis D. Pope

Faraday Discuss., 2013, 165, 343
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The fluorescently responsive 3-(naphthalen-1-ylethynyl)-3-deaza-2′-deoxyguanosine discriminates cytidine via the DNA minor groove

Azusa Suzuki, Masaki Yanagi, Takuya Takeda, Robert H. E. Hudson and Yoshio Saito

Org. Biomol. Chem., 2017, 15, 7853
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A fluorescent 3,7-bis-(naphthalen-1-ylethynylated)-2′-deoxyadenosine analogue reports thymidine in complementary DNA by a large emission Stokes shift

Masaki Yanagi, Azusa Suzuki, Robert H. E. Hudson and Yoshio Saito

Org. Biomol. Chem., 2018, 16, 1496
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Molecular rotors as reporters for viscosity of solutions of collagen like peptides

Christopher D. McTiernan, Matias Zuñiga-Bustos, Roberto Rosales-Rojas, Pablo Barrias, May Griffith, Horacio Poblete, Peter S. Sherin, Ismael López-Duarte, Marina K. Kuimova and Emilio I. Alarcon

Phys. Chem. Chem. Phys., 2021, 23, 24545
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A molecular rotor for measuring viscosity in plasma membranes of live cells

Ismael López-Duarte, Thanh Truc Vu, M. Angeles Izquierdo, James A. Bull and Marina K. Kuimova

Chem. Commun., 2014, 50, 5282
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A novel membrane with heterogeneously functionalized nanocrystal layers performing blood separation and sensing synchronously

Zhenyu Chu, Linlin Li, Gongping Liu and Wanqin Jin

Chem. Commun., 2016, 52, 12706
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Dual use of porphyrazines as sensitizers and viscosity markers in photodynamic therapy

M. Angeles Izquierdo, Aurimas Vyšniauskas, Svetlana A. Lermontova, Ilya S. Grigoryev, Natalia Y. Shilyagina, Irina V. Balalaeva, Larisa G. Klapshina and Marina K. Kuimova

J. Mater. Chem. B, 2015, 3, 1089
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K+ preference at the NaK channel entrance revealed by fluorescence lifetime and anisotropy analysis of site-specifically incorporated (7-hydroxycoumarin-4-yl)ethylglycine

Sanling Liu, Pei Lv, Dong Li, Xiaoqi Guo, Bo Zhang, Mu Yu, Dandan Li, Ying Xiong, Longhua Zhang and Changlin Tian

Chem. Commun., 2015, 51, 15971
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Flapping viscosity probe that shows polarity-independent ratiometric fluorescence

Ryota Kotani, Hikaru Sotome, Hajime Okajima, Soichi Yokoyama, Yumi Nakaike, Akihiro Kashiwagi, Chigusa Mori, Yuki Nakada, Shigehiro Yamaguchi, Atsuhiro Osuka, Akira Sakamoto, Hiroshi Miyasaka and Shohei Saito

J. Mater. Chem. C, 2017, 5, 5248
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A series of dual-responsive Coumarin-Bodipy probes for local microviscosity monitoring

Javier Ordóñez-Hernández, Arturo Jiménez-Sánchez, Héctor García-Ortega, Nuria Sánchez-Puig, Marcos Flores-Álamo, Rosa Santillan and Norberto Farfán

Dyes and Pigments, 2018, 157, 305
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Molecular Rotors: Fluorescent Sensors for Microviscosity and Conformation of Biomolecules

Miguel Paez‐Perez and Marina K. Kuimova

Angew Chem Int Ed, 2024, 63
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Specifically and wash-free labeling of SNAP-tag fused proteins with a hybrid sensor to monitor local micro-viscosity

Chao Wang, Xinbo Song, Lingcheng Chen and Yi Xiao

Biosensors and Bioelectronics, 2017, 91, 313
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Chemical tags: inspiration for advanced imaging techniques

Zhixing Chen, Virginia W Cornish and Wei Min

Current Opinion in Chemical Biology, 2013, 17, 637
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Synthesis of solvatofluorochromic 7-arylethynylated 7-deaza-2′-deoxyadenosine derivatives: application to the design of environmentally sensitive fluorescent probes forming stable DNA duplexes

Azusa Suzuki, Kohki Kimura, Shinya Ishioroshi, Isao Saito, Nobukatsu Nemoto and Yoshio Saito

Tetrahedron Letters, 2013, 54, 2348
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A Molecular Rotor that Measures Dynamic Changes of Lipid Bilayer Viscosity Caused by Oxidative Stress

Aurimas Vyšniauskas, Maryam Qurashi and Marina K. Kuimova

Chemistry A European J, 2016, 22, 13210
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Suppression of Kasha's rule as a mechanism for fluorescent molecular rotors and aggregation-induced emission

Hai Qian, Morgan E. Cousins, Erik H. Horak, Audrey Wakefield, Matthew D. Liptak and Ivan Aprahamian

Nature Chem, 2017, 9, 83
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Linker length affects photostability of protein-targeted sensor of cellular microviscosity

Markéta Kubánková, Joseph E Chambers, Roland G Huber, Peter J Bond, Stefan J Marciniak and Marina K Kuimova

Methods Appl. Fluoresc., 2019, 7, 044004
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Implementing fluorescence enhancement, quenching, and FRET for investigating flap endonuclease 1 enzymatic reaction at the single-molecule level

Mohamed A. Sobhy, Muhammad Tehseen, Masateru Takahashi, Amer Bralić, Alfredo De Biasio and Samir M. Hamdan

Computational and Structural Biotechnology Journal, 2021, 19, 4456
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Using molecular rotors to investigate hemoglobin concentration and heterogeneity in red blood cells

A. Briole, M. Marin, C. Le Van Kim and B. Abou

Journal of Rheology, 2025, 69, 463
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Imaging tumor microscopic viscosity in vivo using molecular rotors

Lyubov’ E. Shimolina, Maria Angeles Izquierdo, Ismael López-Duarte, James A. Bull, Marina V. Shirmanova, Larisa G. Klapshina, Elena V. Zagaynova and Marina K. Kuimova

Sci Rep, 2017, 7
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Mechanism and Nature of the Different Viscosity Sensitivities of Hemicyanine Dyes with Various Heterocycles

Jianfang Cao, Chong Hu, Fei Liu, Wen Sun, Jiangli Fan, Fengling Song, Shiguo Sun and Xiaojun Peng

ChemPhysChem, 2013, 14, 1601
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Nucleoside-Based Ultrasensitive Fluorescent Probe for the Dual-Mode Imaging of Microviscosity in Living Cells

Jianping Li, Yanyan Zhang, Hua Zhang, Xiaopeng Xuan, Mingsheng Xie, Shuang Xia, Guirong Qu and Haiming Guo

Anal. Chem., 2016, 88, 5554
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Tuning Optical Absorption and Emission Using Strongly Coupled Dimers in Programmable DNA Scaffolds

Stephanie M. Hart, Xiao Wang, Jiajia Guo, Mark Bathe and Gabriela S. Schlau-Cohen

J. Phys. Chem. Lett., 2022, 13, 1863
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A twisted tale: measuring viscosity and temperature of microenvironments using molecular rotors

Aurimas Vyšniauskas and Marina K. Kuimova

International Reviews in Physical Chemistry, 2018, 37, 259
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Cy3‐Based Nanoviscosity Determination of Mucus: Effect of Mucus Collection Methods and Antibiotics Treatment

Jacqueline Gottwald, Jens Balke, Johannes Stellmacher, Kira van Vorst, Fereshteh Ghazisaeedi, Marcus Fulde and Ulrike Alexiev

Macromolecular Bioscience, 2024, 24
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Initial state of DNA-Dye complex sets the stage for protein induced fluorescence modulation

Fahad Rashid, Vlad-Stefan Raducanu, Manal S. Zaher, Muhammad Tehseen, Satoshi Habuchi and Samir M. Hamdan

Nat Commun, 2019, 10
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Discovery of the First Environment-Sensitive Near-Infrared (NIR) Fluorogenic Ligand for α1-Adrenergic Receptors Imaging in Vivo

Zhao Ma, Yuxing Lin, Yanna Cheng, Wenxiao Wu, Rong Cai, Shouzhen Chen, Benkang Shi, Bo Han, Xiaodong Shi, Yubin Zhou, Lupei Du and Minyong Li

J. Med. Chem., 2016, 59, 2151
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Interaction of a Dimeric Single-Stranded DNA-Binding Protein (G5P) with DNA Hairpins. A Molecular Beacon Study

Tihomir Solomun, Leo Cordsmeier, Dorothea C. Hallier, Harald Seitz and Marc Benjamin Hahn

J. Phys. Chem. B, 2023, 127, 8131
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Tuning the Sensitivity of Fluorescent Porphyrin Dimers to Viscosity and Temperature

Aurimas Vyšniauskas, Dong Ding, Maryam Qurashi, Igor Boczarow, Milan Balaz, Harry L. Anderson and Marina K. Kuimova

Chemistry A European J, 2017, 23, 11001
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Recent Development of Chemosensors Based on Cyanine Platforms

Wen Sun, Shigang Guo, Chong Hu, Jiangli Fan and Xiaojun Peng

Chem. Rev., 2016, 116, 7768
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Cytoplasmic Delivery and Selective, Multicomponent Labeling with Oligoarginine-Linked Protein Tags

Xiaoyan Zou, Megha Rajendran, Darren Magda and Lawrence W. Miller

Bioconjugate Chem., 2015, 26, 460
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Molecular rotors in haemoglobin and bovine serum albumin proteins

Alice Briole and Bérengère Abou

J. R. Soc. Interface., 2022, 19
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Förster resonance energy transfer and protein-induced fluorescence enhancement as synergetic multi-scale molecular rulers

Evelyn Ploetz, Eitan Lerner, Florence Husada, Martin Roelfs, SangYoon Chung, Johannes Hohlbein, Shimon Weiss and Thorben Cordes

Sci Rep, 2016, 6
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Expanding the Scope of Reporting Nanoparticles: Sensing of Lipid Phase Transitions and Nanoviscosities in Lipid Membranes

Katja Ober, Pierre Volz-Rakebrand, Johannes Stellmacher, Robert Brodwolf, Kai Licha, Rainer Haag and Ulrike Alexiev

Langmuir, 2019, 35, 11422
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“Probe, Sample, and Instrument (PSI)”: The Hat-Trick for Fluorescence Live Cell Imaging

Ludovic Galas, Thibault Gallavardin, Magalie Bénard, Arnaud Lehner, Damien Schapman, Alexis Lebon, Hitoshi Komuro, Patrice Lerouge, Stéphane Leleu and Xavier Franck

Chemosensors, 2018, 6, 40
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Enhancing the Viscosity‐Sensitive Range of a BODIPY Molecular Rotor by Two Orders of Magnitude

Stepas Toliautas, Jelena Dodonova, Audrius Žvirblis, Ignas Čiplys, Artūras Polita, Andrius Devižis, Sigitas Tumkevičius, Juozas Šulskus and Aurimas Vyšniauskas

Chemistry A European J, 2019, 25, 10342
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Dual mode monitoring probe for mitochondrial viscosity in single cell

Na Jiang, Jiangli Fan, Si Zhang, Tong Wu, Jingyun Wang, Pan Gao, Junle Qu, Fan Zhou and Xiaojun Peng

Sensors and Actuators B: Chemical, 2014, 190, 685
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In vivodegradation profile of porcine cartilage-derived extracellular matrix powder scaffolds using a non-invasive fluorescence imaging method

Hyeon Joo Kim, Soyeon Lee, Hee-Woong Yun, Xiang Yun Yin, Soon Hee Kim, Byung Hyune Choi, Young Jick Kim, Moon Suk Kim and Byoung-Hyun Min

Journal of Biomaterials Science, Polymer Edition, 2016, 27, 177
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Synthesis of ethynylpyrene-modified 3-deaza-2′-deoxyguanosines as environmentally sensitive fluorescent nucleosides: Target DNA-sequence detection via changes in the fluorescence wavelength

Takuya Takeda, Masaki Yanagi, Azusa Suzuki, Ryuzi Katoh and Yoshio Saito

Tetrahedron Letters, 2019, 60, 825
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Molecular Rotors: Fluorescent Sensors for Microviscosity and Conformation of Biomolecules

Miguel Paez‐Perez and Marina K. Kuimova

Angewandte Chemie, 2024, 136
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An Optical Technique for Mapping Microviscosity Dynamics in Cellular Organelles

Joseph E. Chambers, Markéta Kubánková, Roland G. Huber, Ismael López-Duarte, Edward Avezov, Peter J. Bond, Stefan J. Marciniak and Marina K. Kuimova

ACS Nano, 2018, 12, 4398
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Chemical Analysis of Single Cells

Raphaël Trouillon, Melissa K. Passarelli, Jun Wang, Michael E. Kurczy and Andrew G. Ewing

Anal. Chem., 2013, 85, 522
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