Hairpin ODN-based ligands as potential inhibitors of HMGB1 cytokine activity

Domenica Musumeci, Giovanni N. Roviello, Daniela Montesarchio, Roberto Sapio, Margherita Valente, Valentina Anrò and Enrico M. Bucci

RSC Adv., 2013, 3, 12176
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Dynamic Autoinhibition of the HMGB1 Protein via Electrostatic Fuzzy Interactions of Intrinsically Disordered Regions

Xi Wang, Harry M. Greenblatt, Lavi S. Bigman, Binhan Yu, Channing C. Pletka, Yaakov Levy and Junji Iwahara

Journal of Molecular Biology, 2021, 433, 167122
DOI: 10.1016/j.jmb.2021.167122

Artificial genetic polymers against human pathologies

Gleb S. Ivanov, Vyacheslav G. Tribulovich, Nikolay B. Pestov, Temitope I. David, Abdul-Saleem Amoah, Tatyana V. Korneenko and Nikolai A. Barlev

Biol Direct, 2022, 17
DOI: 10.1186/s13062-022-00353-7

When annealing is detrimental: The case of HMGB1-targeting G-quadruplex aptamers

Ettore Napolitano, Andrea Criscuolo, Claudia Riccardi, Chiara Platella, Rosa Gaglione, Angela Arciello, Domenica Musumeci and Daniela Montesarchio

International Journal of Biological Macromolecules, 2024, 283, 137148
DOI: 10.1016/j.ijbiomac.2024.137148

Directing in Vitro Selection towards G‐quadruplex‐forming Aptamers to Inhibit HMGB1 Pathological Activity

Ettore Napolitano, Andrea Criscuolo, Claudia Riccardi, Carla L. Esposito, Silvia Catuogno, Gabriele Coppola, Giovanni N. Roviello, Daniela Montesarchio and Domenica Musumeci

Angewandte Chemie, 2024, 136
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Analysis of the anti-inflammatory effect of the aptamer LA27 and its binding mechanism

Hua Ye, You Zhou, Pengfei Ma, Yuanxin Guo and Zhouping Wang

International Journal of Biological Macromolecules, 2020, 165, 308
DOI: 10.1016/j.ijbiomac.2020.09.052

Sterile inflammation and pregnancy complications: a review

Mathieu Nadeau-Vallée, Dima Obari, Julia Palacios, Marie-Ève Brien, Cyntia Duval, Sylvain Chemtob and Sylvie Girard

Reproduction, 2016, 152, R277
DOI: 10.1530/REP-16-0453

Directing in Vitro Selection towards G‐quadruplex‐forming Aptamers to Inhibit HMGB1 Pathological Activity

Ettore Napolitano, Andrea Criscuolo, Claudia Riccardi, Carla L. Esposito, Silvia Catuogno, Gabriele Coppola, Giovanni N. Roviello, Daniela Montesarchio and Domenica Musumeci

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202319828

The multifunctional protein HMGB1: 50 years of discovery

Daolin Tang, Rui Kang, Herbert J. Zeh and Michael T. Lotze

Nat Rev Immunol, 2023, 23, 824
DOI: 10.1038/s41577-023-00894-6

An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies

Domenica Musumeci, Giovanni N. Roviello and Daniela Montesarchio

Pharmacology & Therapeutics, 2014, 141, 347
DOI: 10.1016/j.pharmthera.2013.11.001

Cell Membrane-Coated Oil in Water Nano-Emulsions as Biomimetic Nanocarriers for Lipophilic Compounds Conveyance

Martina Profeta, Concetta Di Natale, Elena Lagreca, Valentina Mollo, Paolo Antonio Netti and Raffaele Vecchione

Pharmaceutics, 2021, 13, 1069
DOI: 10.3390/pharmaceutics13071069

High Mobility Group Box-1 (HMGb1): Current Wisdom and Advancement as a Potential Drug Target

Sonya VanPatten and Yousef Al-Abed

J. Med. Chem., 2018, 61, 5093
DOI: 10.1021/acs.jmedchem.7b01136

Fluorescent Thrombin Binding Aptamer-Tagged Nanoparticles for an Efficient and Reversible Control of Thrombin Activity

Claudia Riccardi, Irene Russo Krauss, Domenica Musumeci, François Morvan, Albert Meyer, Jean-Jacques Vasseur, Luigi Paduano and Daniela Montesarchio

ACS Appl. Mater. Interfaces, 2017, 9, 35574
DOI: 10.1021/acsami.7b11195

Polyvalent nucleic acid aptamers and modulation of their activity: a focus on the thrombin binding aptamer

Domenica Musumeci and Daniela Montesarchio

Pharmacology & Therapeutics, 2012, 136, 202
DOI: 10.1016/j.pharmthera.2012.07.011

Sequestering HMGB1 via DNA-Conjugated Beads Ameliorates Murine Colitis

Zhongliang Ju, Sangeeta S. Chavan, Daniel J. Antoine, Meghan Dancho, Teá Tsaava, Jianhua Li, Ben Lu, Yaakov A. Levine, Andrew Stiegler, Yehuda Tamari, Yousef Al-Abed, Jesse Roth, Kevin J. Tracey, Huan Yang and David L. Boone

PLoS ONE, 2014, 9, e103992
DOI: 10.1371/journal.pone.0103992

Conformation and protein interactions of intramolecular DNA and phosphorothioate four-way junctions

Maria Troisi, Mitchell Klein, Andrew C Smith, Gaston Moorhead, Yonatan Kebede, Raymond Huang, Elliott Parker, Hector Herrada, Elizabeth Wade, Samara Smith, Payson Broome, Jonah Halsell, Louis Estevez and Anthony J Bell

Exp Biol Med (Maywood), 2021, 246, 707
DOI: 10.1177/1535370220973970

Unraveling the NMR structures of G-quadruplex-forming aptamers acting as inhibitors of High Mobility Group Box 1 (HMGB1) pathological activity

Marko Trajkovski, Chiara Platella, Domenica Musumeci, Ettore Napolitano, Carla Lucia Esposito, Silvia Catuogno, Janez Plavec and Daniela Montesarchio

International Journal of Biological Macromolecules, 2026, 357, 151585
DOI: 10.1016/j.ijbiomac.2026.151585

HMGB1 in health and disease

Rui Kang, Ruochan Chen, Qiuhong Zhang, Wen Hou, Sha Wu, Lizhi Cao, Jin Huang, Yan Yu, Xue-gong Fan, Zhengwen Yan, Xiaofang Sun, Haichao Wang, Qingde Wang, Allan Tsung, Timothy R. Billiar, Herbert J. Zeh, Michael T. Lotze and Daolin Tang

Molecular Aspects of Medicine, 2014, 40, 1
DOI: 10.1016/j.mam.2014.05.001

Covalently linked dimers of a G-quadruplex-forming aptamer as HMGB1 inhibitors

Andrea Criscuolo, Ettore Napolitano, Claudia Riccardi, Rosa Gaglione, Erika Piccolo, Angela Arciello, Domenica Musumeci and Daniela Montesarchio

International Journal of Biological Macromolecules, 2025, 332, 148479
DOI: 10.1016/j.ijbiomac.2025.148479

Interaction of HMG proteins and H1 with hybrid PNA–DNA junctions

Filbert Totsingan and Anthony J. Bell

Protein Science, 2013, 22, 1552
DOI: 10.1002/pro.2342

Negatively charged, intrinsically disordered regions can accelerate target search by DNA-binding proteins

Xi Wang, Lavi S Bigman, Harry M Greenblatt, Binhan Yu, Yaakov Levy and Junji Iwahara

Nucleic Acids Research, 2023, 51, 4701
DOI: 10.1093/nar/gkad045