The first zwitterionic cocrystal of indomethacin with amino acid showing optimized physicochemical properties as well as accelerated absorption and slowed elimination in vivo

Ling-Yang Wang, Yue-Ming Yu, Fu-Bin Jiang, Yan-Tuan Li, Zhi-Yong Wu and Cui-Wei Yan

New J. Chem., 2020, 44, 3930
DOI: 10.1039/C9NJ06180K

Challenges and opportunities of pharmaceutical cocrystals: a focused review on non-steroidal anti-inflammatory drugs

Utsav Garg and Yasser Azim

RSC Med. Chem., 2021, 12, 705
DOI: 10.1039/D0MD00400F

Structure determination of the theophylline–nicotinamide cocrystal: a combined powder XRD, 1D solid-state NMR, and theoretical calculation study

Ping Li, Yueying Chu, Lin Wang, Robert M. Wenslow, Kaichao Yu, Hailu Zhang and Zongwu Deng

CrystEngComm, 2014, 16, 3141
DOI: 10.1039/C4CE00012A

Application of hydrogen-bond propensity calculations to an indomethacin–nicotinamide (1 : 1) co-crystal

Mridul Majumder, Graham Buckton, Clare F. Rawlinson-Malone, Adrian C. Williams, Mark J. Spillman, Elna Pidcock and Kenneth Shankland

CrystEngComm, 2013, 15, 4041
DOI: 10.1039/c3ce40367j

Affinity prediction computations and mechanosynthesis of carbamazepine based cocrystals

Luisa Roca-Paixão, Natália T. Correia and Frédéric Affouard

CrystEngComm, 2019, 21, 6991
DOI: 10.1039/C9CE01160A

Crystal growth and morphology control of needle-shaped organic crystals

Patrick McArdle and Andrea Erxleben

CrystEngComm, 2024, 26, 416
DOI: 10.1039/D3CE01041D

What Has Carbamazepine Taught Crystal Engineers?

Amy V. Hall, Aurora J. Cruz-Cabeza and Jonathan W. Steed

Crystal Growth & Design, 2024, 24, 7342
DOI: 10.1021/acs.cgd.4c00555

Engineering Codrug Solid Forms: Mechanochemical Synthesis of an Indomethacin–Caffeine System

Simone Bordignon, Paolo Cerreia Vioglio, Emanuele Priola, Dario Voinovich, Roberto Gobetto, Yusuke Nishiyama and Michele R. Chierotti

Crystal Growth & Design, 2017, 17, 5744
DOI: 10.1021/acs.cgd.7b00748

Impact of Halogen Substituent Nature and Position on the Structural and Energetic Properties of Carbamazepine Cocrystals with Meta‐Halobenzoic Acids: A Two‐Pathway Synthesis Study

Artur Mirocki and Mattia Lopresti

ChemPlusChem, 2025, 90
DOI: 10.1002/cplu.202500474

Carbamazepine/Tartaric Acid Cocrystalline Forms: When Stoichiometry and Synthesis Method Matter

Luisa Roca-Paixão, Natália T. Correia, Florence Danède, Mathieu Guerain and Frédéric Affouard

Crystal Growth & Design, 2023, 23, 1355
DOI: 10.1021/acs.cgd.2c00859

Co-crystallization in Antiepileptic Drugs: A Path Toward Better Therapeutic Outcomes

Bhagyashree Patil, Sanjay Surana and Atul Shirkhedkar

Cureus, 2025
DOI: 10.7759/cureus.82230

Coupling complementary strategy to flexible graph neural network for quick discovery of coformer in diverse co-crystal materials

Yuanyuan Jiang, Zongwei Yang, Jiali Guo, Hongzhen Li, Yijing Liu, Yanzhi Guo, Menglong Li and Xuemei Pu

Nat Commun, 2021, 12
DOI: 10.1038/s41467-021-26226-7

The principles underlying the use of powder diffraction data in solving pharmaceutical crystal structures

Kenneth Shankland, Mark J. Spillman, Elena A. Kabova, David S. Edgeley and Norman Shankland

Acta Crystallogr C Cryst Struct Commun, 2013, 69, 1251
DOI: 10.1107/S0108270113028643

Salt formation of two BCS II drugs (indomethacin and naproxen) with (1R, 2R)-1,2-diphenylethylenediamine: Crystal structures, solubility and thermodynamics analysis

Qiang Fu, Hai-Dong Lu, Yi-Fei Xie, Jia-You Liu, Yang Han, Ning-Bo Gong and Fang Guo

Journal of Molecular Structure, 2019, 1185, 281
DOI: 10.1016/j.molstruc.2019.02.104

Ionic Cocrystals of Pharmaceutical Compounds: Sodium Complexes of Carbamazepine

Amanda R. Buist and Alan R. Kennedy

Crystal Growth & Design, 2014, 14, 6508
DOI: 10.1021/cg501400n

Salt Forms of Amides: Protonation and Polymorphism of Carbamazepine and Cytenamide

Amanda R. Buist, Alan R. Kennedy, Kenneth Shankland, Norman Shankland and Mark J. Spillman

Crystal Growth & Design, 2013, 13, 5121
DOI: 10.1021/cg401341y

Structural Characterization of Pharmaceutical Cocrystals with the Use of Laboratory X-ray Powder Diffraction Patterns

Vladimir V. Chernyshev

Crystals, 2023, 13, 640
DOI: 10.3390/cryst13040640

A COMPREHENSIVE REVIEW ON MULTI-DRUG COCRYSTALS

Monika Nijhawan, Bhavana Jidige, Pavan Kumar Thota, Rajeswari Aleti and Neelima Rambakka

IND. DRU., 2025, 62, 8
DOI: 10.53879/id.62.04.15016

The role of π–π, C–H⋯halogen, and halogen⋯π interactions in the crystal packing of 9-aminoacridinium 3-halobenzoate salts: an experimental and theoretical investigation

Patryk Nowak, Artur Sikorski and Artur Mirocki

Struct Chem, 2026
DOI: 10.1007/s11224-026-02758-w

Co-Crystal Structures of Furosemide:Urea and Carbamazepine:Indomethacin Determined from Powder X-Ray Diffraction Data

Okba Al Rahal, Mridul Majumder, Mark J. Spillman, Jacco van de Streek and Kenneth Shankland

Crystals, 2020, 10, 42
DOI: 10.3390/cryst10010042

Drug‑Drug and Drug‑Nutraceutical Cocrystal/Salt as Alternative Medicine for Combination Therapy: A Crystal Engineering Approach

Ranjit Thakuria and Bipul Sarma

Crystals, 2018, 8, 101
DOI: 10.3390/cryst8020101

Make and break - Facile synthesis of cocrystals and comprehensive dissolution studies

L. Batzdorf, N. Zientek, D. Rump, F. Fischer, M. Maiwald and F. Emmerling

Journal of Molecular Structure, 2017, 1133, 18
DOI: 10.1016/j.molstruc.2016.11.063

Carbamazepine Dihydroxybenzoic Acid Cocrystals: Exploring Packing Interactions and Reaction Kinetics

Inês C. B. Martins and Franziska Emmerling

Crystal Growth & Design, 2021, 21, 6961
DOI: 10.1021/acs.cgd.1c00902

Cocrystal Systems of Pharmaceutical Interest: 2011

Harry G. Brittain

Crystal Growth & Design, 2012, 12, 5823
DOI: 10.1021/cg301114f

Utilizing organic and organometallic structural data in powder diffraction

Jason C. Cole, Elena A. Kabova and Kenneth Shankland

Powder Diffr., 2014, 29, S19
DOI: 10.1017/S0885715614000827

Supramolecular synthonic portions in heat-treated indomethacin-carbamazepine mixture: a singular value decomposition approach for Fourier-Transform infrared spectral analysis

Wataru Kuwashima, Kanji Hasegawa, Chihiro Tsunoda, Sae Sunada, Tomohiro Tsuchida and Satoru Goto

International Journal of Pharmaceutics, 2025, 685, 126199
DOI: 10.1016/j.ijpharm.2025.126199

Compromised in vitro dissolution and membrane transport of multidrug amorphous formulations

Amjad Alhalaweh, Christel A.S. Bergström and Lynne S. Taylor

Journal of Controlled Release, 2016, 229, 172
DOI: 10.1016/j.jconrel.2016.03.028

Carbamazepine cocrystals with several aromatic carboxylic acids in different stoichiometries: Structures and solid state characterization

Qiang Fu, Yang Han, Yi-fei Xie, Ning-bo Gong and Fang Guo

Journal of Molecular Structure, 2018, 1168, 145
DOI: 10.1016/j.molstruc.2018.04.100

Investigation of Ternary Phase Diagrams of Carbamazepine–Nicotinamide Cocrystal in Ethanol and Ethanol/Ethyl Acetate Mixtures at 298.15 K and 313.15 K

Yaohui Huang, Xiaowei Sun, Ling Zhou, Zaixiang Zhang, Shihao Zhang and Qiuxiang Yin

J Solution Chem, 2020, 49, 117
DOI: 10.1007/s10953-019-00944-5

Drug-drug cocrystals: Opportunities and challenges

Xiaojuan Wang, Shuzhang Du, Rui Zhang, Xuedong Jia, Ting Yang and Xiaojian Zhang

Asian Journal of Pharmaceutical Sciences, 2021, 16, 307
DOI: 10.1016/j.ajps.2020.06.004

Novel Drug–Drug Cocrystalline Forms of Carbamazepine with Sulfacetamide: Preparation, Characterization, and In Vitro/In Vivo Performance Evaluation

Denis E. Boycov, Ksenia V. Drozd, Alex N. Manin, Andrei V. Churakov, Mikhail Yu. Vlasov, Irina V. Kachalkina and German L. Perlovich

Pharmaceutics, 2025, 17, 678
DOI: 10.3390/pharmaceutics17050678

Structure determination, thermal stability and dissolution rate of δ-indomethacin

Iryna Andrusenko, Victoria Hamilton, Arianna E. Lanza, Charlie L. Hall, Enrico Mugnaioli, Jason Potticary, Asma Buanz, Simon Gaisford, Anna M. Piras, Ylenia Zambito, Simon R. Hall and Mauro Gemmi

International Journal of Pharmaceutics, 2021, 608, 121067
DOI: 10.1016/j.ijpharm.2021.121067

Continuous Manufacturing of Cocrystals Using Solid State Shear Milling Technology

Sachin Korde, Sudhir Pagire, He Pan, Colin Seaton, Adrian Kelly, Yinghong Chen, Qi Wang, Phil Coates and Anant Paradkar

Crystal Growth & Design, 2018, 18, 2297
DOI: 10.1021/acs.cgd.7b01733

Salt and Ionic Cocrystalline Forms of Amides: Protonation of Carbamazepine in Aqueous Media.

Amanda R. Buist, David S. Edgeley, Elena A. Kabova, Alan R. Kennedy, Debbie Hooper, David G. Rollo, Kenneth Shankland and Mark J. Spillman

Crystal Growth & Design, 2015, 15, 5955
DOI: 10.1021/acs.cgd.5b01223

Two-Component Pharmaceutical Cocrystals Regulated by Supramolecular Synthons Comprising Primary N···H···O Interactions

Hai-Lei Cao, Jun-Ru Zhou, Feng-Ying Cai, Jian Lü and Rong Cao

Crystal Growth & Design, 2019, 19, 3
DOI: 10.1021/acs.cgd.8b01663