Development of a new hydrophobic auxiliary, TCbz group at the N-terminus of peptides is disclosed. This auxiliary enabled C-terminal modification in LPPS and a de novo solid/hydrophobic-tag relay synthesis (STRS) of calpinactam.
Here, we disclose the first total synthesis of tetraselide and determination of its absolute structure. We implemented bioinformatic analyses, chemical degradation, chiral pool fragment synthesis and convergent synthesis of this natural product.
Owing to their special spatial structures, peptide-based macrocycles have recently shown tremendous promise in multidisciplinary research ranging from potent antibiotics against resistant strains to functional biomaterials with novel properties.
Perovskite materials have emerged as a class of multifunctional materials with exceptional optoelectronic, physical and chemical properties, which have aroused great interest in their applications in functional fibers and fabrics.
The ammonia-Ugi reaction employing ammonium carboxylates of N-protected amino acids (or peptides), ketones, and α-isocyano esters enabled N-to-C peptide elongation, together with in situ construction of α,α-disubstituted amino acid residues.