Two types of silicon-based hydrophobic tags, including a siloxy group containing tag and an arylsilyl group containing tag, were developed for applying them in tag-assisted liquid-phase peptide synthesis (Tag LPPS) to synthesize long peptides.
Development of a new hydrophobic auxiliary, TCbz group at the N-terminus of peptides is disclosed. This auxiliary enabled C-terminal modification in LPPS and a de novo solid/hydrophobic-tag relay synthesis (STRS) of calpinactam.
Here, we disclose the first total synthesis of tetraselide and determination of its absolute structure. We implemented bioinformatic analyses, chemical degradation, chiral pool fragment synthesis and convergent synthesis of this natural product.
Developing greener synthesis processes is an inescapable necessity to transform the industrial landscape, mainly in the pharmaceutical sector, into a long-term, sustainable reality.
Owing to their special spatial structures, peptide-based macrocycles have recently shown tremendous promise in multidisciplinary research ranging from potent antibiotics against resistant strains to functional biomaterials with novel properties.