The aza-Friedel–Crafts (aza-FC) reaction is a very powerful tool for forming C–C and C–N bonds, based on an acid-catalyzed addition of electron-rich aromatic compounds to imines.
A class of novel pyrrolinone ketimines was synthesized for the first time and applied to the asymmetric aza-Friedel–Crafts reaction with phenolic compounds.
We report a chiral phosphoric acid-catalyzed asymmetric aza-Friedel–Crafts reaction of newly developed indeno[1,2-b]quinoxalin-11-imines for the efficient synthesis of diverse chiral 11-amino-indeno[1,2-b]quinoxaline derivatives.
A novel protocol to access an aziridine-fused heterotricyclo[4.3.0.02,9]decane framework was developed via a CPA-catalyzed asymmetric aza-Darzens reaction of quinoxalin-2(1H)-ones with diazoacetates, followed by LiAlH4-mediated reductive cyclization.
A review of recent research progress in the synthesis of α-trifluoromethyl amines through the asymmetric reduction of trifluoromethylated imines and nucleophilic addition to trifluoromethylated imines.