A mild, metal-free one-pot synthesis of N-substituted quinazolinones from 2-aminobenzamide, phenylacetylene, and DMSO is described. DMSO acts as both solvent and synthon, enabling C–C/C–X bond formation through tandem annulation.
Simple synthesis, binds and inhibits tubulin, and potent broad-spectrum cytotoxicity.
Facile syntheses of quinazolinone derivatives are reported. Electron-rich keto-pyrazole moieties are utilised to produce a Cu(II) catalyst. It facilitates intramolecular cyclization via a non-radical two-electron hydride pathway with excellent yield.
The activation and utilization of challenging aliphatic alcohols like methanol and ethanol is a very appealing approach to synthesize valuable organic molecules.
Two fruits felled with one stone! – a proof of mechanism and a synthetic method that delivers a privileged heterocyclic motif.