We report a nanoparticle system based on PMLA to enhance drug delivery, improve cellular uptake, and achieve controlled intracellular drug release owing to enzyme-sensitive linker named AANL and pH-sensitive bond named cis-aconitic anhydride bond.
This review highlights bioorthogonal reaction mediated size transformation clustered nanosystems, summarizing the bioorthogonal reaction-based design principles and the effectiveness on bioimaging quality and therapeutic outcomes.
Biomaterial-based drug delivery systems (DDSs) for GBM drug delivery are classified as organic, inorganic and cell-based nanoparticles.
This review summarizes insights into colorant selection and signal mechanisms for the development of colorimetric sensing and POC sensors.
Stereochemically dense 5-oxo-pyrrolidines were obtained by combining the Castagnoli–Cushman reaction with directed Pd-catalyzed C(sp3)–H functionalization and enabling the identification of two BACE-1 enzyme inhibitors with sub-micromolar activity.