This review summarizes the applications of late-stage strategies in the direct trifluoromethylation of natural products in the past ten years, with particular emphasis on the reaction model of each method.
In celebration of our 15th anniversary and some of our most popular articles, Alicia Casitas and Xavi Ribas reflect on the area of organometallic copper(III) chemistry, charting developments since their review in Chemical Science on this topic: https://doi.org/10.1039/C3SC21818J.
Atom-economical trifluoromethylation of (hetero)arenes, including selected biomolecules, was achieved using a substoichiometric amount of a Cu(III) trifluoromethyl complex.
The trifluoromethylation of primary and secondary benzylic C(sp3)−H bonds by CuII species proceeds via a radical recombination/reductive elimination pathway, while tertiary benzylic C(sp3)−H bonds prefer the single-electron transfer (SET) pathway.
A well-defined [Ph4P]+[Cu(CF2CF3)2]− complex acts as a versatile pentafluoroethylating reagent for the construction of C(sp3)–, C(sp2)– and C(sp)–CF2CF3 bonds.