This review summarizes the most recent progress made in C–H bond activation-initiated spiroannulation reactions and their applications in the construction of structurally diverse and biologically valuable spirocyclic scaffolds.
An unprecedented Rh(III)-catalyzed [3+2] spiroannulation enables access to architecturally complex C2-spiro-[indene-1,2′-indolin] scaffolds with a broad substrate scope and excellent yields.
An unprecedented Rh(III)-catalyzed [3+2] spiroannulation enables access to architecturally complex spiro[4.6]dibenzoxazepane-indanosuccinimide scaffolds with broad scope and excellent yields.
The advancements in the synthesis of nitrogen-containing heterocycles via Rh(III)-catalyzed chelation-assisted tandem C–H activation/carbene insertion/annulation with diazo compounds as carbene precursors have been summarized.
We have developed a new, simple methodology that allows the formation of well-defined highly enantioselective active species containing two different monodentate ligands coordinated at the same time to the metal center (ML1L2).