The use of a supramolecular protecting molecular container, whose host-guest properties are under acid–base control, enables the functionalization with high chemo-, regio- and iteroselectivities of polyamines in a one-pot cyclic process.
In the last decade numerous techniques have been developed in Pd-catalysed distal C–H activation ranging from template-assisted to the use of inherent functional groups as the directing auxiliary including ligand-enabled transformations.
Direct alteration of unactivated C–H bonds of organic building blocks.
Palladium complexes with mono-N-protected amino acid ligands (MPAA) have been prepared as models to experimentally study the C–H activation of arenes. Their reactivity shows the validity of the chelating model with the assistance of the acyl group.
Multigram synthesis and physicocochemical characterization of (oxa)azaspiro[2.n]alkane derivatives – promising scaffolds for drug discovery – are reported.