Pd-catalysed C–H functionalisation of free carboxylic acids has drawn significant attention over the last few years due to the predominance of carboxylic acid moieties in pharmaceuticals and agrochemicals.
Three complexes, [Pd(L2)2Br2](C1), [(L2)PdCl(μ-Cl)2PdCl(L2)](C2), and [Pd(L2)PPh3Cl2](C3), where L2 = 2,2′-tellurobis(N,N-diphenylacetamide), catalyze Suzuki–Miyaura coupling (loading: 0.001 mol % of Pd) of eleven ArX at room temperature under air.
β-Nucleosides are fundamental building blocks of biological systems and are used as therapeutic agents for the treatment of cancer and viral infections. This review summarizes the stereoselective synthesis of β-nucleosides and their analogues.
The use of a supramolecular protecting molecular container, whose host-guest properties are under acid–base control, enables the functionalization with high chemo-, regio- and iteroselectivities of polyamines in a one-pot cyclic process.
In the last decade numerous techniques have been developed in Pd-catalysed distal C–H activation ranging from template-assisted to the use of inherent functional groups as the directing auxiliary including ligand-enabled transformations.