An approach to unprecedented 4-(pyridin-2-yloxy)-1,2,4-thiadiazol-5(4H)-ones was developed. The method involves amidoximes O-heteroarylation by pyridine N-oxides with PyBroP activation, followed by condensation with chlorocarbonylsulfenyl chloride.
A strategy for the construction of 3,5-disubstituted-1,2,4-oxadiazoles by intermolecular cyclization of amidoximes with benzyl thiols was developed under transition metal-free conditions.
A metal-free, iodine-catalyzed protocol for the synthesis of biologically significant 5-aroyl 1,2,4-oxadiazole scaffolds has been developed using aryl methyl ketones and amidoximes.
Summary of the synthesis, computational analysis, and in vitro antimicrobial evaluation of amidoxime-based benzimidazole and benzimidamide derivatives.
A scalable and environment-friendly one-pot two-component synthesis of chiral N-protected amino acid substituted 1,2,4-oxadiazoles from hydroxyl amidine and (S)-2-(2,2,2-trifluoroacetamido)propanoic 2,2,2-trifluoroacetic anhydride is described.