Herein, we report a Stevens rearrangement ring expansion of isoindolines to N-alkyl-2-aroyl-tetrahydroisoquinolines, followed by a photochemical nitrogen atom extruding ring contraction and elimination to give indene derivatives.
A concise strategy to prepare polycyclic heteroaromatics involving a deaminative contraction cascade is detailed.
This review highlights recent advances in the asymmetric synthesis of α-tertiary amine natural products via temporary chirality induction methods: Seebach's self-regeneration of stereocenters, C-to-N-to-C chirality transfer, and memory of chirality.
Single-atom editing (contraction, expansion, deletion, and insertion) precisely modifies cyclic frameworks, enabling step-efficient synthesis of drugs, natural products, and advanced materials.
A novel copper(I)-catalyzed cascade reaction has been devised for the functionalization of thiazoles, which employs two molar equivalents of an α-aryl-α-diazoester.