In this work we report a waste-minimized continuous flow process for the synthesis of β-aminocarbonyls through hydration of N-Boc-2-azetines promoted under acid-catalysed conditions.
Heterocycles consisting nitrogen are a potent bioactive compounds, that have extensive application in agrochemistry, materials research, and medicinal chemistry. An overview of the synthesis of N-heterocycles using visible-light photoredox catalysis has been provided in this article.
DFT study clarifies phosphine-catalyzed [2+2] cycloaddition and BF3-mediated ring-opening to axially chiral alkenes. Stereoselectivity relies on transition-state low-distortion structures and synergistic noncovalent interactions.
This review aims to provide an overview of the biosyntheses of the striking azetidine-containing natural products, with an emphasis on the biosynthetic mechanisms of naturally occurring azetidines.
An organocatalytic domino reaction of β-alkyl nitroolefins with alkylidene malononitriles to give azetidine nitrones with good diastereoselectivities is reported. The in situ-generated nitrones were transmuted into isoxazoles catalyzed by acid.