Nanozymes with biomimetically designed properties for cancer treatment

Ke Xu, Yujie Cui, Bin Guan, Linlin Qin, Dihao Feng, Abudumijiti Abuduwayiti, Yimu Wu, Hao Li, Hongfei Cheng and Zhao Li

Nanoscale, 2024, 16, 7786
DOI: 10.1039/D4NR00155A

A comprehensive exploration of the latest innovations for advancements in enhancing selectivity of nanozymes for theranostic nanoplatforms

Dan Li, Tuocen Fan and Xifan Mei

Nanoscale, 2023, 15, 15885
DOI: 10.1039/D3NR03327A

Nanozyme-enabled cancer theranostics: bridging enzyme mimicry and material intelligence

Yupeng Wang, Xinxin Sun, Shunfeng Wang, Zhixiao Zhang, Jin Sun, Cong Luo, Zhonggui He and Shenwu Zhang

Mater. Horiz., 2025, 12, 8895
DOI: 10.1039/D5MH01000D

A sensitive dopamine colorimetric sensing platform based on Co3ZnC/co/co-N-C nanozyme with high oxidase-like activity

Jiawen Xu, Ze Lv, Hong Xu and Zhiping Mao

Microchemical Journal, 2025, 215, 114361
DOI: 10.1016/j.microc.2025.114361

High-throughput and reliable detection of algal toxins in salt ponds using a novel multicolor immunoassay based on double-electron oxidation driven by ultra-strong Co-Mn3O4 nanozyme

Qiong Huang, Hong Geng, Zhihong Zhang, Quanxi Zhang, Li Wu, Zhiping Li, Jianwei Yue and Daizhou Zhang

Microchemical Journal, 2026, 225, 117937
DOI: 10.1016/j.microc.2026.117937

Recent Advances in Oxidase-like Nanozymes: Mechanisms, Prediction Models, and Applications

Xiaoli Wang, Qiao-Zhi Li, Yuliang Zhao and Xingfa Gao

ACS Appl. Mater. Interfaces, 2025, 17, 66110
DOI: 10.1021/acsami.5c15196

Structure Regulation of Single‐atom Catalysts for Electrocatalytic Sensing

Yijin Shu, Qijie Mo and Qingsheng Gao

ChemCatChem, 2024, 16
DOI: 10.1002/cctc.202301634

Graphitic C6N6‐Supported Dual Cu/Zn Single‐Atom Nanozyme Mimicking Allosteric Regulation for Intelligent Switching Biosensing

Qing Hong, Yuanjie Ma, Caixia Zhu, Kaiyuan Wang, Hong Yang, Kaiqing Wu, Yanfei Shen, Songqin Liu, Xuejiao J. Gao and Yuanjian Zhang

Angewandte Chemie, 2026, 138
DOI: 10.1002/ange.202520253

Nanozymes regulated by nitrogen element: Mechanism, design, and application

Longhua Ding, Longwei Wang, Jian Zhang, Na Ren, Aizhu Wang, Hong Liu and Xin Yu

Advanced Powder Materials, 2024, 3, 100191
DOI: 10.1016/j.apmate.2024.100191

Single nanozyme-based colorimetric biosensor for dopamine with enhanced selectivity via reactivity of oxidation intermediates

Caixia Zhu, Qing Hong, Kaiyuan Wang, Yanfei Shen, Songqin Liu and Yuanjian Zhang

Chinese Chemical Letters, 2024, 35, 109560
DOI: 10.1016/j.cclet.2024.109560

Aluminum-Decorated MIL-100(Fe) Nanozyme for the Detection of Glutathione

Lin Cui, Xinshuo Zhao, Jiankang Zhang, Zhan Zhou, Dong Lin and Yong Qin

ACS Appl. Nano Mater., 2024, 7, 4764
DOI: 10.1021/acsanm.3c05262

A novel lignin peroxidase-mimicking by CoO-Co2VO4/C nanocomposite and its application in sensing fungal metabolite veratryl alcohol

Yuanyuan Cai, Chuyuan Lin, Mingyang Wang, Yujiao Zhang, Guangze Sun, Lingxing Zeng and Aihua Liu

Biosensors and Bioelectronics, 2026, 294, 118200
DOI: 10.1016/j.bios.2025.118200

Boosted Electrocatalytic Oxygen Reduction Performance of Porous Co-NC Catalysts by the Coexistence of Abundant Co–N4 and g-N Sites

Ji-Rui Bai, Kai Zhang, Jia-Yao Gao, Shi-Feng Zhao, Peng-Cheng Ma, Zeng-Yu Han, Kai-Bo Pu, Wen-Fang Cai, Qing-Yun Chen and Yun-Hai Wang

Ind. Eng. Chem. Res., 2023, 62, 13412
DOI: 10.1021/acs.iecr.3c01527

Peroxidase-like active Cu-ZIF-8 with rich copper(I)-nitrogen sites for excellent antibacterial performances toward drug-resistant bacteria

Xiaoze Wang, Hui Wang, Jingkun Zhang, Ning Han, Wenjun Ma, Donghai Zhang, Mingshui Yao, Xianliang Wang and Yunfa Chen

Nano Res., 2024, 17, 7427
DOI: 10.1007/s12274-024-6699-x

Cu-MOF-confined Co nanoparticle nanozymes with synergistic peroxidase-like activity for highly selective colorimetric detection of hydroquinone

Tanzeel Riaz Ahmad, Xin Li, Ling Jiang, Jie Jin, Xiupei Yang and Fenglin Tang

Analytica Chimica Acta, 2026, 1416, 345736
DOI: 10.1016/j.aca.2026.345736

Copper ions coordination-promoted self-assembly of DNA nanoflowers as cascade catalytic nanoreactor for colorimetric biosensor

Zhenjie Qiao, Shuzhen Yue, Xiaoyue Zhang, Pengfei Shi, Shuzhen Lv and Sai Bi

Talanta, 2025, 282, 127049
DOI: 10.1016/j.talanta.2024.127049

Computational Screening-Assisted Design of Bioinspired Artificial Metalloenzymes with Efficient Cascade Biocatalysis To Alleviate Cerebral Ischemia-Reperfusion Injury

Zhenyu Xing, Chan Zhu, Shengdong Mu, Ting Wang, Haojie Xu, Haiyan Xiong, Xikui Liu, Yi Wang, Chong Cheng and Changsheng Zhao

J. Am. Chem. Soc., 2026, 148, 6992
DOI: 10.1021/jacs.5c17695

Metal-Functionalized Nanozymes in Antibacterial Wound Management: Recent Advances and Future Perspectives

Selvam Sathiyavimal, Devaraj Bharathi and Ezhaveni Sathiyamoorthi

Pharmaceuticals, 2026, 19, 333
DOI: 10.3390/ph19020333

Graphitic C6N6‐Supported Dual Cu/Zn Single‐Atom Nanozyme Mimicking Allosteric Regulation for Intelligent Switching Biosensing

Qing Hong, Yuanjie Ma, Caixia Zhu, Kaiyuan Wang, Hong Yang, Kaiqing Wu, Yanfei Shen, Songqin Liu, Xuejiao J. Gao and Yuanjian Zhang

Angew Chem Int Ed, 2026, 65
DOI: 10.1002/anie.202520253

Unraveling the Proximity Effects of a Co–P Dual Site in Phosphorus-Coordinated Cobalt Single-Atom Nanozymes

Peng Xu, Wendong Liu, Yuanyuan Jiang, Riming Hu, Mingyuan Xia, Kepeng Song, Shushu Chu, Shibo Xi and Yizhong Lu

ACS Nano, 2025, 19, 41911
DOI: 10.1021/acsnano.5c18031

Synergy between platinum and oxygen vacancy in CeO2 boosting enzyme-mimicking activity

Jiao Xiao, Xinyi Yang, Xinshuo Zhao, Fengmin Qin, Xiubo Yang, Lin Cui, Zhan Zhou, Dong Lin, Zunfu Hu, Yong Qin and Jiankang Zhang

Biochemical Engineering Journal, 2024, 202, 109165
DOI: 10.1016/j.bej.2023.109165

All Nanozyme‐Based Cascade Reactions for Biomedical Applications: from Self‐Cascading Nanozyme to Immobilized Cascade Nanozyme

Caixia Zhu, Congcong Jiang, Hian Kee Lee, Yuanjian Zhang and Sheng Tang

Advanced Science, 2026, 13
DOI: 10.1002/advs.202519656

Immobilization Protocols of Nanozyme with Different Morphologies in Microfluidic Chips for Biosensing

Caixia Zhu, Kaiyuan Wang, Yanqin Lv, Songqin Liu, Yanfei Shen and Yuanjian Zhang

ACS Appl. Mater. Interfaces, 2025
DOI: 10.1021/acsami.5c14204

Bimetallic copper/cobalt-doped nanozyme based fluorescence and electrochemistry dual-modal sensor for dopamine detection

Junwen Feng, Jiayi Tang, Congcong Jiang, Caixia Zhu, Dongyang Wang and Sheng Tang

Microchemical Journal, 2026, 222, 117147
DOI: 10.1016/j.microc.2026.117147

Nanozymes expanding the boundaries of biocatalysis

Ruofei Zhang, Xiyun Yan, Lizeng Gao and Kelong Fan

Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-62063-8

Natural Enzymes and Nanozymes: A Comparative Review of Structure, Mechanism and Kinetics

Manoharmayum Vishwanath Sharma, A. Ibeyaima, Bhaben Sharmah, Nazim Uddin Afzal and Prasenjit Manna

Top Catal, 2026, 69, 1385
DOI: 10.1007/s11244-025-02201-0